Enterovirus detection in patients with acute gastroenteritis in Switzerland

Gosert, Rainer; Heininger, Ulrich; Hirsch, Hans H.

doi:10.1002/jmv.25005

Cited by 16 publications

(12 citation statements)

References 43 publications

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“…While most epidemiological studies on enteric viruses in children identified rotavirus as the first viral cause of acute sporadic gastroenteritis [24,25,26,27,28], we found a higher positivity rate for adenovirus, which could be biased on the fact that positive samples for rotavirus and adenovirus by immunochromatography were excluded from the analyses. Yet, two other recent studies also identified higher prevalence of adenovirus than rotavirus infection among a cohort of children with gastroenteritis using real-time PCR assays [29,30], including one study that focused on the post rotavirus vaccine era [30].…”

Section: Discussioncontrasting

confidence: 68%

Novel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain

Sabrià

Aregall

et al. 2019

Viruses

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A remarkable percentage of acute gastroenteritis cases remain etiologically undiagnosed. The aim of the study was to determine the prevalence of common and emerging enteric viruses, such as novel human astroviruses, among undiagnosed samples from children with acute gastroenteritis. Epidemiological studies for novel human astroviruses are still scarce. Stool samples collected over two consecutive winter seasons (2016–2017) from children with gastroenteritis in Spain, which were negative for bacteria, rotavirus, and adenovirus by routine diagnostics were screened by real-time RT-PCR assays for the presence of classical and novel astrovirus, rotavirus, norovirus GI and GII, sapovirus, and adenovirus. Overall, 220/384 stool samples (57.3%) were positive for at least one virus. Co-infections were identified in 21% of cases. Among a total of 315 viruses identified, adenovirus was the most prevalent (n = 103), followed by rotavirus (n = 51), sapovirus (n = 50), classical astrovirus (n = 43), novel astroviruses (n = 42), and norovirus (n = 26). Novel astroviruses were present in 13.3% of virus-positive cases. Most novel astroviruses were found in children <2-year-old (30/39 children, 77%, p = 0.01) and were found in co-infection (66%). Only classical astroviruses demonstrated significant differences in the Cq values during mono-infections compared to co-infections. In conclusion, common enteric viruses may be frequently found in children with undiagnosed gastroenteritis, indicating the need to implement more sensitive diagnostic methods. Novel astroviruses circulate in the community and could be the cause of gastroenteritis among young children.

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Section: Discussioncontrasting

confidence: 68%

Novel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain

Sabrià

Aregall

et al. 2019

Viruses

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“…The reported incidence of bacterial gastroenteritis caused by less prevalent pathogens including Salmonella, STEC and L. monocytogenes were 14.7, 8.4 and 0.67 per 100,000 population in 2020, respectively (European Food Safety Authority, 2021b). A study by Gosert et al examined the detection of viral and bacterial pathogens from 677 stool samples collected from 504 patients with acute gastroenteritis between 2013 and 2015, and found that rotavirus (126/677), norovirus (82/677) and enterovirus (36/677) were the most prevalent viral pathogens, whilst Clostridium difficile(39/ 677) and Campylobacter(16/677) were the most prevalent bacterial pathogens (Gosert et al, 2018).…”

Section: Switzerlandmentioning

confidence: 99%

“…A study by Gosert et al. examined the detection of viral and bacterial pathogens from 677 stool samples collected from 504 patients with acute gastroenteritis between 2013 and 2015, and found that rotavirus (126/677), norovirus (82/677) and enterovirus (36/677) were the most prevalent viral pathogens, whilst Clostridium difficile (39/677) and Campylobacter (16/677) were the most prevalent bacterial pathogens ( Gosert et al., 2018 ).…”

Section: Epidemiologymentioning

confidence: 99%

Global epidemiology of campylobacteriosis and the impact of COVID-19

Liu

Lee

Xue

et al. 2022

Front. Cell. Infect. Microbiol.

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Campylobacteriosis is a gastroenteritis caused by pathogenic Campylobacter species and an important topic in public health. Here we review the global epidemiology of campylobacteriosis in the last eight years between 2014-2021, providing comprehensive and updated information on the reported incidence and outbreaks of Campylobacter infections. The government public health website of each of the 195 countries and publications from 2014 to September 2022 in public databases were searched. The reported incidence of campylobacteriosis in pre-COVID-19 years was compared to that during the COVID-19 pandemic in countries where data were available. Czech Republic had the highest reported incidence of campylobacteriosis worldwide (215 per 100,000 in 2019), followed by Australia (146.8 per 100,000 in 2016) and New Zealand (126.1 per 100,000 in 2019). Campylobacter was one of the most common human enteric pathogens in both developed and developing countries. About 90% of cases of campylobacteriosis were caused by Campylobacter jejuni, whereas less than 10% of cases were caused by Campylobacter coli. Other Campylobacter species were also isolated. The reported incidence and case numbers of campylobacteriosis in developed nations have remained steadily high prior to the COVID-19 pandemic, whilst some countries reported an increasing trend such as France and Japan. While outbreaks were more frequently reported in some countries, Campylobacter infections were mainly sporadic cases in most of the developed countries. Campylobacter infection was more common in summer in some but not all countries. Campylobacter infection was more common in males than females. The COVID-19 pandemic has reduced the reported incidence of campylobacteriosis in most countries where 2020 epidemiology data were available. In conclusion, Campylobacter infection remains a global health concern. Increased research and improved strategies are needed for prevention and reduction of Campylobacter infection.

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“…[ 1 2 ] They include rotavirus, norovirus, astrovirus, sapovirus, enteric adenovirus, parechovirus, enterovirus as well as other typically nonenteric infections that may manifest as diarrhea and vomiting such as influenza and coronaviruses. [ 3 4 5 6 7 8 ]Enteric viruses are also detected as part of co-infections, for which clinical significance has not been determined. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Rotavirus and adenovirus in children evaluated for viral gastroenteritis at a single healthcare center in the Eastern Province of Saudi Arabia: A perspective of two decades

Alqurayn,

Obeid,

Alkharsah

2024

Journal of Family and Community Medicine

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BACKGROUND: The aim of this study was to determine the distribution of rotavirus and adenovirus in pediatric patients evaluated for viral gastroenteritis in a hospital in the Eastern Province of Saudi Arabia for 22 years. MATERIALS AND METHODS: This was a retrospective study based in a secondary healthcare center in Saudi Arabia. Laboratory and demographic data were collected from hospital records for all pediatric patients (up to 14 years old) evaluated for viral gastroenteritis by rotavirus/adenovirus antigen detection kit from January 2000 to December 2022. Data were analyzed utilizing SPSS version 28.0. Categorical data were presented as frequency and percentages, whereas mean and standard deviations were computed for continuous variables. Chi-square test and t-test were used to determine statistical significance. RESULTS: The overall yields of antigen detection were 13.6% for rotavirus and 2.6% for adenovirus. Coinfection with both viruses was documented in 0.5% of the study population. Rotavirus was persistently detected in the past two decades with varying frequency, but the detection of adenovirus showed intervals of at least three consecutive years of zero confirmed cases. Before 2013, when the rotavirus vaccine was introduced in Saudi Arabia, rotavirus was much more prevalent than adenovirus (30% compared to 3.8% in 2010), but they became equally prevalent a decade after the introduction of the vaccine. Rotavirus gastroenteritis showed three different peaks in the year, in March, July, and December. Each peak was followed by a gradual decrease in prevalence before the next peak. Adenovirus, in contrast, was detected consistently around the year at rates between 2% and 5%. CONCLUSION: Rotavirus and adenovirus gastroenteritis have changed in prevalence in the past two decades. We found distinct seasonal patterns associated with rotavirus and adenovirus gastroenteritis. The utilization of virological testing for pediatric gastroenteritis with syndromic testing panels is to be encouraged to improve the knowledge of the true prevalence of enteric viruses.

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Enterovirus detection in patients with acute gastroenteritis in Switzerland

Cited by 16 publications

References 43 publications

Novel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain

Novel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain

Global epidemiology of campylobacteriosis and the impact of COVID-19

Rotavirus and adenovirus in children evaluated for viral gastroenteritis at a single healthcare center in the Eastern Province of Saudi Arabia: A perspective of two decades

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