Enteroviruses and Parechoviruses

Pallansch, Mark A.; Oberste, M. Steven

doi:10.1128/9781555815974.ch18

Cited by 10 publications

(1 citation statement)

References 359 publications

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“…Enteroviruses (EVs) are a large group of positive-sense single-stranded RNA viruses belonging to the Enterovirus genus from the family Picornaviridae , and include four human enterovirus species, EV-A to–D [ 1 ]. Among them, human echovirus 11 (ECHO 11) belongs to EV-B and is one of the most commonly isolated enteroviruses [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Wang

Yang

et al. 2022

PLoS Pathog

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Echovirus 11 (ECHO 11) is a positive-strand RNA virus belonging to the genus Enterovirus of the family Picornaviridae. ECHO 11 infections can cause severe inflammatory illnesses in neonates, including severe acute hepatitis with coagulopathy. The activation of NLRP3 inflammasome is important for host defense against invading viruses, which also contributes to viral pathogenicity. However, whether and how ECHO 11 induces NLRP3 inflammasome activation remains unclear. In this study, we isolated a clinical strain of ECHO 11 from stools of an ECHO 11-infected newborn patient with necrotizing hepatitis. This virus shared 99.95% sequence identity with the previously published ECHO 11 sequence. The clinically isolated ECHO 11 can efficiently infect liver cells and strongly induces inflammation. Moreover, we showed that ECHO 11 induced IL-1β secretion and pyroptosis in cells and mouse bone marrow-derived macrophages (BMDMs). Furthermore, ECHO 11 infection triggered NLRP3 inflammasome activation, as evidenced by cleavages of GSDMD, pro-IL-1β and pro-caspase-1, and the release of LDH. ECHO 11 2B protein was required for NLRP3 inflammasome activation via interacting with NLRP3 to facilitate the inflammasome complex assembly. In vivo, expression of ECHO 11 2B also activated NLRP3 inflammasome in the murine liver. Besides, 2Bs of multiple EVs can also interact with NLRP3 and induce NLRP3 inflammasome activation. Together, our findings demonstrate a mechanism by which ECHO 11 induces inflammatory responses by activating NLRP3 inflammasome, providing novel insights into the pathogenesis of ECHO 11 infection.

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Section: Introductionmentioning

confidence: 99%

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Wang

Yang

et al. 2022

PLoS Pathog

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Enteroviruses and Parechoviruses

Stellrecht,

Lamson,

Romero

2023

ClinMicroNow

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Enteroviruses (EVs) are members of the Picornaviridae family, with “pico” meaning very small, “rna” indicating an RNA genome, and “viridae” signifying viruses. Traditional criteria for taxonomy and identification of EVs to subgroups were based on patterns of replication in cell cultures, clinical syndromes, or disease and on disease manifestations in suckling mice. EVs and Parechoviruses (PeVs) cause a wide array of both localized and systemic infections that affect many organ systems in patients of all ages. Specimen selection is important for making a diagnosis of EV infection, as asymptomatic shedding, especially in stool, is common. Nucleic acid amplification tests, such as reverse transcriptase PCR, are the recommended method for the detection of EV and PeV because of their enhanced sensitivity and rapid turnaround times. In the clinical setting, situations may arise where EV serology is requested; such is the case for myocarditis and determination of congenital infection in pregnant women.

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Enteroviruses and Parechoviruses: Echoviruses, Coxsackieviruses, and Others

Oberste

Gerber

2014

Viral Infections of Humans

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Enteroviruses and Parechoviruses

Cited by 10 publications

References 359 publications

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Enteroviruses and Parechoviruses

Enteroviruses and Parechoviruses: Echoviruses, Coxsackieviruses, and Others

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