“…In recent years, the amide exchange reaction (AER) has been used increasingly to synthesize DAPs by pharmaceutical companies and in research laboratories. 6,7 Among the many different DAPs, hexamethylenebisacetamide (HMBA) [8][9][10] is a major anti-carcinogen and medical-chemical intermediate used in the synthesis of different organic chemicals, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] including hexamethylenetertamine (HMTA), diethyl hexamethylenedicarbamate (EHDC), and diphenyl hexamethylenedicarbamate (PHDC), (Fig. 1).…”