Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)

Guo, Wei; Venkataraman, S.; Yang, Yi Yan; Hedrick, James L.; Prabhu, Vivek M.

doi:10.1016/j.polymer.2017.11.057

Cited by 10 publications

(6 citation statements)

References 49 publications

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“…These interactions are attenuated at a higher temperature, and micellization is promoted following breakage of water structures. 35 This promotes their self-assembly at a lower copolymer concentration.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

et al. 2023

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We present a comprehensive investigation on the interaction of tetronics (T1304 and T1307) with some important physiological salts (NaH2PO4, KH2PO4, Na2CO3, NaCl, and KI). Thermodynamic and microstructural aspects of these interactions were studied as a function of the solution temperature, pH and salt concentration. Characterizations were performed using turbidimetric, calorimetric, and scattering techniques. We show that, at ambient temperature, T1304 molecules aggregated to form spherical core–shell aggregates displaying a unimodal distribution pattern. On the other hand, unimers and large clusters dominated in the case of highly hydrophilic T1307. Its micellization was promoted in the presence of salts as per the following trend: NaCl < KH2PO4 < NaH2PO4 ≪ Na2CO3. Aggregation was found to be endothermic, and hydrophobic interactions (TΔS mic > ΔH mic) prevailed. The enthalpy–entropy compensation plot was found to be linear for both copolymers. Demicellization occurred in the presence of KI as it facilitated the buildup of water structures around the copolymer chains. This could be verified from the increase in the cloud point, critical micelle concentration, and free energy. Overall, the temperature and salts inflicted a stronger hydrophobic effect upon T1304 in comparison to T1307.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

et al. 2023

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“…In water, no reliable light-scattering signal was observed for polycations at 100 ppm (Table ), indicating that polycations do not form stable aggregates at such low concentration. Neat SDBS at 100 ppm exists as unimers in water because its critical micelle concentration (CMC) is measured as 127 ppm at room temperature with a fluorescent pyrene probe method (Figure S8). Our CMC of 127 ppm corroborates the reported CMC of 131 ppm for SDBS at 25 °C .…”

Section: Resultsmentioning

confidence: 99%

Fast-Bactericidal Effect of Polyion Complex Nanoparticles on Gram-Negative Bacteria

Guo

Nguyễn

Reghu

et al. 2020

ACS Appl. Nano Mater.

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There is urgent need for effective bactericidal agents for use in real commercial formulations since many old disinfectants, such as halogenated compounds, are now banned. Cationic polymers may have good bactericidal properties in pure water or buffer, but typically become ineffective in the presence of anionic surfactants that are widely used in many commercial formulations. Here, we discover that polyion complex (PIC) nanoparticles formed by cationic polymers of Poly(3-AcrylaMidoPropyl) TriMethylAmmonium chloride (PAMPTMA) in the presence of anionic surfactants display promising fast-bactericidal effect (> 99.99 % killing within 10-min treatment) on Gram-negative Escherichia coli (E. coli, ATCC ® 8739™). To examine the influence of hydrophobicity on bactericidal property, we synthesize PAMPTMA-b-Poly(Butyl MethAcrylate) and discover that increasing hydrophobicity has little influence on bactericidal property of PIC nanoparticles. Mechanism study shows that cationic PIC nanoparticles rapidly cause significant pores both in the outer-and inner-membranes because of their large size and high local concentration of positive charges. The rapid membrane pore formation results in fast cell death. The discovery --certain cationic polymers when formulated with anionic surfactants are even more bactericidal than neat cationic polymers alone --paves the way for potential applications of synthetic cationic polymers in commercial formulations.

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“…However, according to Wei et al . 's work, 39 the scaling of the ln(CMC) with degree of polymerization of the structure driving group typically scales as 1/3 to 2/3 (ln(CMC) ~ m 1/3– 2/3 , where m is the hydrophobic block length). The m of F68‐CDEC is 2, which is lower than values of other cholesterol‐bearing polymers ( m = 8, 11 and 18) and causes the CMC of F68‐CDEC to be relatively higher.…”

Section: Resultsmentioning

confidence: 99%

“…Compared to this similar work, the CMC of F68-CDEC is not small enough. However, according to Wei et al's work, 39 the scaling of the ln(CMC) with degree of polymerization of the structure driving group typically scales as 1/3 to 2/3 (ln(CMC) ∼ m 1/3-2/3 , where m is the hydrophobic block length).…”

Section: Characterization Of Micelles and Drug-loaded Micellesmentioning

confidence: 99%

Reduction‐sensitive carrier containing disulfide bond based on Pluronic F68 with cholesterol for drug delivery

Zhang

Fan

et al. 2020

Polymer International

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The reduction-sensitive amphiphilic polymer chol-SS-F68-SS-Chol (F68-CDEC. chol, SS and F68 represent cholesterol, disulfide bond and Pluronic F68, respectively) was easily synthesized by two steps of esterification reactions. The self-assembly behavior of the polymer was studied by fluorescence spectrophotometry, dynamic light scattering and TEM. Impressively, the critical micelle concentration of F68-CDEC was 58-fold smaller than that of F68. Besides, the drug loading content (LC = 20.25%) was higher than that of F68 (LC = 13.42%). In vitro release experiments showed that the reductant dithiothreitol triggered rapid disintegration of micelles with an accumulated drug amount of 55%, compared with an accumulated drug amount of 20% in phosphate-buffered saline solution. These good abilities were further proved by cell uptake experiments. More importantly, almost no cytotoxicity was observed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay and immunofluorescence staining experiments. There are reasons to believe that the polymer F68-CDEC can be used as a reduction-sensitive drug delivery material.

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Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)

Cited by 10 publications

References 49 publications

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

Fast-Bactericidal Effect of Polyion Complex Nanoparticles on Gram-Negative Bacteria

Reduction‐sensitive carrier containing disulfide bond based on Pluronic F68 with cholesterol for drug delivery

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