Entrainment of neural oscillations as a modifiable substrate of attention

Calderone, Daniel; Lakatos, Péter L.; Butler, Pamela D.; Castellanos, F. Xavier

doi:10.1016/j.tics.2014.02.005

Cited by 246 publications

(216 citation statements)

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“…It has been argued that lowfrequency neuronal oscillations might reflect a cortical mechanism for sensory selection, attentional allocation, and evidence updating during decision making (9,11,13,14,32). If the underlying functional brain architecture is inherently rhythmic, then we should be able to observe rhythmic patterns in behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Here we demonstrate that delta activity (2-4 Hz) in the prefrontal cortex tracked the current task context and modulated sensory processing in a top-down manner. We show that frontal delta and parietooccipital alpha (8)(9)(10)(11)(12) oscillations are functionally coupled and jointly guide visual perception to integrate sensory evidence with current task demands. We observed strong moment-to-moment behavioral fluctuations, which cycled at the rate of the endogenous prefrontal oscillatory brain activity.…”

Section: Significancementioning

confidence: 90%

“…S1A, for individual spectra). First, we compared the mean power in the canonical alpha band (8)(9)(10)(11)(12) Hz) between conditions by means of a two-way repeated measures (RM)-ANOVA (Fig. 1F).…”

Section: Perceptual Alpha Cycles Are Modulated By Lower Frequencies Dmentioning

confidence: 99%

“…It has been suggested that slow-frequency activity in the delta range (<5 Hz) might reflect a mechanism for endogenous attentional selection and predictions (9, 10). In particular, endogenous low-frequency entrainment is thought to reflect a substrate of top-down processing (11)(12)(13)(14). Importantly, endogenous entrainment does not require rhythmicity in the input stream but reflects an intrinsic mechanism to enable predictions (15).…”

mentioning

confidence: 99%

“…However, it is currently unclear how contextual information is dynamically integrated to support visual perception. Numerous studies have shown that visual perception critically depends on prestimulus alpha-band (8)(9)(10)(11)(12) Hz) activity (3)(4)(5)(6)(7). The gating-by-inhibition hypothesis postulates that alpha serves as a mechanism to route information to task-relevant cortical sites (8) but might also be under top-down control (6,7).…”

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confidence: 99%

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Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

106

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Conscious visual perception is proposed to arise from the selective synchronization of functionally specialized but widely distributed cortical areas. It has been suggested that different frequency bands index distinct canonical computations. Here, we probed visual perception on a fine-grained temporal scale to study the oscillatory dynamics supporting prefrontal-dependent sensory processing. We tested whether a predictive context that was embedded in a rapid visual stream modulated the perception of a subsequent near-threshold target. The rapid stream was presented either rhythmically at 10 Hz, to entrain parietooccipital alpha oscillations, or arrhythmically. We identified a 2-to 4-Hz delta signature that modulated posterior alpha activity and behavior during predictive trials. Importantly, deltamediated top-down control diminished the behavioral effects of bottom-up alpha entrainment. Simultaneous source-reconstructed EEG and cross-frequency directionality analyses revealed that this delta activity originated from prefrontal areas and modulated posterior alpha power. Taken together, this study presents converging behavioral and electrophysiological evidence for frontal deltamediated top-down control of posterior alpha activity, selectively facilitating visual perception.top-down control | directional cross-frequency coupling | prefrontal cortex | alpha oscillations | phase-amplitude coupling V isual perception is flexible, selective, and rapidly integrates sensory evidence with endogenous high-level expectations and predictions (1, 2). It has been suggested that rhythmic brain activity constitutes a key mechanism to coordinate information flow in the human cerebral cortex by transiently forming task-relevant largescale networks (1). However, it is currently unclear how contextual information is dynamically integrated to support visual perception. Numerous studies have shown that visual perception critically depends on prestimulus alpha-band (8-12 Hz) activity (3-7). The gating-by-inhibition hypothesis postulates that alpha serves as a mechanism to route information to task-relevant cortical sites (8) but might also be under top-down control (6, 7). However, it is currently unclear which cortical regions and mechanisms mediate the directed top-down control of alpha oscillations (2). It has been suggested that slow-frequency activity in the delta range (<5 Hz) might reflect a mechanism for endogenous attentional selection and predictions (9, 10). In particular, endogenous low-frequency entrainment is thought to reflect a substrate of top-down processing (11)(12)(13)(14). Importantly, endogenous entrainment does not require rhythmicity in the input stream but reflects an intrinsic mechanism to enable predictions (15). Several studies have demonstrated that visual perception cycles as a function of the alpha phase but only a few reports have demonstrated that multiple rhythms modulate behavior on a fine-grained temporal scale (5,(16)(17)(18)(19).At present, it is uncertain how different temporal scales interact t...

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Section: Discussionmentioning

confidence: 99%

Section: Significancementioning

confidence: 90%

Section: Perceptual Alpha Cycles Are Modulated By Lower Frequencies Dmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

106

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Dyslexia

Archer

Pammer

2021

Encyclopedia of Life Sciences

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Dyslexia is a disorder characterised by difficulty in learning to read that cannot be attributed to secondary organic, mechanical or social circumstances. In other words, a child fails to learn to read at an age‐appropriate rate, irrespective of intelligence level, education or other neurological deficits. Notably, developmental dyslexia – which is the focus of this article – is distinct from acquired dyslexia, which occurs due to brain trauma. Numerous sensory and cognitive deficits contribute to dyslexia, including difficulties with auditory processing of speech sounds, visual processing and working memory. Current research is aimed at understanding the neurobiological cause of these cognitive deficits. Key Concepts Dyslexia is a universal and persistent form of low literacy in which a child fails to learn to read at an age‐appropriate rate. It is found across languages and is not associated with intelligence, age, education or other neurological deficits. Symptoms of dyslexia and their severity can vary significantly from one individual to the next. People with dyslexia have been found to have Impaired phonological processing – that is, a decreased perceptual sensitivity to sound‐segments in language. Difficulties with short‐term memory. Impaired visual processing. Spelling difficulties. Phonological dyslexia refers to difficulties in sounding words out and making phonological manipulations. Surface dyslexia refers to difficulties in developing and accessing a lexicon, that is a mental representation of words. Dyslexia is often confused with visual stress – the symptoms of which include words moving when attempting to read, shimmering or disappearing, words looking like they were carved into the page, lines or rivers through the text, and preferring to read under very low light levels. The exact aetiology of dyslexia is unknown; however, evidence indicates deficits in magnocellular‐dorsal stream processing in the visual domain and impaired brainwave function in the auditory domain. Several genetic mutations have also been identified in dyslexia. Current remedial interventions for dyslexia are educational and are aimed at improving cognitive deficits. Current research is aimed at identifying the neurobiological basis of dyslexia to aid the development of a treatment that targets the underlying neurobiological cause of dyslexia.

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Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum

Wiesman,

Gallego‐Rudolf,

Villeneuve

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONDespite parallel research indicating amyloid‐β accumulation, alterations in cortical neurophysiological signaling, and multi‐system neurotransmitter disruptions in Alzheimer's disease (AD), the relationships between these phenomena remains unclear.METHODSUsing magnetoencephalography, positron emission tomography, and an atlas of 19 neurotransmitters, we studied the alignment between neurophysiological alterations, amyloid‐β deposition, and the neurochemical gradients of the cortex.RESULTSIn patients with mild cognitive impairment and AD, changes in cortical rhythms were topographically aligned with cholinergic, serotonergic, and dopaminergic systems. These alignments correlated with the severity of clinical impairments. Additionally, cortical amyloid‐β plaques were preferentially deposited along neurochemical boundaries, influencing how neurophysiological alterations align with muscarinic acetylcholine receptors. Most of the amyloid‐β‐neurochemical and alpha‐band neuro‐physio‐chemical alignments replicated in an independent dataset of individuals with asymptomatic amyloid‐β accumulation.DISCUSSIONOur findings demonstrate that AD pathology aligns topographically with the cortical distribution of chemical neuromodulator systems and scales with clinical severity, with implications for potential pharmacotherapeutic pathways.Highlights Changes in cortical rhythms in Alzheimer's are organized along neurochemical boundaries. The strength of these alignments is related to clinical symptom severity. Deposition of amyloid‐β (Aβ) is aligned with similar neurotransmitter systems. Aβ deposition mediates the alignment of beta rhythms with cholinergic systems. Most alignments replicate in participants with pre‐clinical Alzheimer's pathology.

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Entrainment of neural oscillations as a modifiable substrate of attention

Cited by 246 publications

References 81 publications

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Dyslexia

Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum

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