A firm’s ability to compete effectively depends on matching its internal operations with various exterior contexts. This research investigated the impact of strategic fit orientation on business agility among female entrepreneurs in Lagos state, Nigeria’s non-oil export sector. This study used a descriptive and quantitative approach to gather information from four hundred and two (402) selected female entrepreneurs actively engaged in non-oil exporting activities in the agribusiness, textile, and information and technology business processing industry. The respondents were purposefully determined, while the data were analyzed using measurement and structural modeling. This study reveals that strategic fit orientation significantly mediates firm strategies and business agility. This means that women entrepreneurs should continually develop structures and strategies to stay agile and strategically fit in the business environment. They are to adapt their objectives strategically to reduce potential risks and assess situations and possible consequences of threats to remain dynamic in the business environment. This study addressed the gap between strategic fit orientation and business agility in developing economies.