This study has proposed a framework to pinpoint factors that could influence the intention to become an entrepreneur among university students from four different Middle East countries. The proposed framework has integrated different explanatory factors that have been used within different approaches into one framework, and assess their relative importance to influence entrepreneurial intentions. Also, the framework was tested on a large diversified multi-country sample from four Middle East countries (Jordan, Lebanon, Egypt, and Oman).The findings stress the role that a university could play at motivating its students to be entrepreneurial and the governmental role in creating a perceived climate that encourages entrepreneurship.