Entrikim Therapeutic Efficacy in Pigs With Enzootic Pneumonia

Abstract

The number of T-lymphocytes in the subacute course decreases to 28.9±1.4% and in the chronic course it increased to 69.1±1.2%. However, against the background of lymphopenia, the absolute value of lymphocytes also decreased to 0.70±0.038·109 /l in the acute form of the disease. In chronic pneumonia, the number of lymphocytes was at the level of 0.44±0.04·109 /l. The T-x/T-c ratio also changed, depending on the form of enzootic pneumonia. With subacute – 1.7, and with chronic – 2.28. The entrikim treatment of piglets with a subacute course carried out for 7 days and a blood test 5 days after the implementation of sanitation showed that the number of Tlymphocytes increased twofold to 1.40±0.04·109 /l, while the Tx/Tc ratio was 2, 28, which corresponds to the physiological norm. After the treatment of piglets with a chronic course, all analyzed parameters characterizing the state of T-cell immunity testified to its normal functioning. A decrease in the total number of T-lymphocytes, individual EAK populations, indicate a depressive state of lymphopoiesis. A decrease in the number of T-lymphocytes to 0.44±0.04·109 /l in chronic course up to indicates a deep suppression of cellular immunity. In the subacute form of the disease, the number of B-lymphocytes decreased to 14.07±1.92%, but increased to 32.64±0.3% in the chronic course. But against the background of lymphopenia in subacute form, the absolute value of lymphocytes decreased to 0.36±0.04·109 /l, and in chronic lymphopenia to 0.20±0.06·109 /l. In the subacute form of the disease, the content of Ig A (1.49±0.03 mg/ml) and Ig G (1.39±0.02 mg/ml) does not differ from healthy animals, but a low level of Ig M (11.0±0.12 mg/ml) indicates a negative effect of mycoplasmas on humoral immunity. In chronic course, there is a sharp decrease (by 30%) Ig A to 1.49±0.03 and vice versa, a sharp increase by 30% in the Ig G content (11.8±011 mg/ml). After treatment of piglets with a subacute course of the disease, the number of B-lymphocytes increased by 2 times, and after treatment with m with a chronic course of the disease, by 3.5 times to 0.70±0.04·109 /L. The use of entrikim has a positive effect on humoral immunity, as the amount of Ig G increases by 45%. The therapeutic efficacy of entrikim increases due to the synergistic interaction of enrofloxacin, trimethoprim and tilmicosin phosphate. The therapeutic efficacy of entrikim in the subacute course was 90.7%, and in the chronic one – 74.4%.