Entropy-driven aggregation in multilamellar membranes

Noguchi, Hiroshi

doi:10.1209/0295-5075/102/68001

Cited by 9 publications

(12 citation statements)

References 30 publications

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“…A similar attraction has previously been obtained for the binding sites of two membranes, when the membranes around the binding sites are hardened [56].…”

Section: B Protein Modelsupporting

confidence: 81%

“…II, the simulation model and method are described. We simulate membrane tubes and vesicles using an implicit-solvent meshless membrane model [48][49][50][53][54][55][56]. A banana-shaped protein rod is assumed to be strongly adsorbed onto the membrane and the protein and membrane region below it are modeled as a linear string of particles with a bending stiffness and preferred curvature.…”

Section: Introductionmentioning

confidence: 99%

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Shape deformation of lipid membranes by banana-shaped protein rods: Comparison with isotropic inclusions and membrane rupture

Noguchi

2016

Phys. Rev. E

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The assembly of curved protein rods on fluid membranes is studied using implicit-solvent meshless membrane simulations. As the rod curvature increases, the rods on a membrane tube assemble along the azimuthal direction first and subsequently along the longitudinal direction. Here, we show that both transition curvatures decrease with increasing rod stiffness. For comparison, curvature-inducing isotropic inclusions are also simulated. When the isotropic inclusions have the same bending rigidity as the other membrane regions, the inclusions are uniformly distributed on the membrane tubes and vesicles even for large spontaneous curvature of the inclusions. However, the isotropic inclusions with much larger bending rigidity induce shape deformation and are concentrated on the region of a preferred curvature. For high rod density, high rod stiffness, and/or low line tension of the membrane edge, the rod assembly induces vesicle rupture, resulting in the formation of a high-genus vesicle. A gradual change in the curvature suppresses this rupture. Hence, large stress, compared to the edge tension, induced by the rod assembly is the key factor determining rupture. For rod curvature with the opposite sign to the vesicle curvature, membrane rupture induces inversion of the membrane, leading to division into multiple vesicles as well as formation of a high-genus vesicle.

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“…A similar attraction has previously been obtained for the binding sites of two membranes, when the membranes around the binding sites are hardened [56].…”

Section: B Protein Modelsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Shape deformation of lipid membranes by banana-shaped protein rods: Comparison with isotropic inclusions and membrane rupture

Noguchi

2016

Phys. Rev. E

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“…A confining surface located at z conf = 6σ completely suppresses thermal undulations, and eliminates the fluctuation mediated interactions between the adhesion bonds. Under these conditions, the threshold value for aggregation increases to [19,21], that the entropic gain of aggregation compensates for, roughly, half of the loss in mixing entropy of the adhesion bonds.…”

Section: A Membranes Under Confinementmentioning

confidence: 99%

“…The fact that adhesion domains do not form for ǫ = 0 implies that the fluctuation entropy gained by the aggregation of the adhesive lipids only partially compensates for their loss of mixing entropy. In another CG simulation study, Noguchi demonstrated that cell junctions connecting more than two membranes can aggregate without an additional attractive potential between them [21]. This observation can be understood because the total entropy of thermal undulations increases linearly with the number of membranes, N m , while the mixing entropy of the cell junctions is independent of N m .…”

Section: Introductionmentioning

confidence: 97%

Formation of adhesion domains in stressed and confined membranes

Dharan

Farago

2015

Soft Matter

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The adhesion bonds connecting a lipid bilayer to an underlying surface may undergo a condensation transition resulting from an interplay between a short range attractive potential between them, and a long range fluctuation-induced potential of mean force. Here, we use computer simulations of a coarse-grained molecular model of supported lipid bilayers to study this transition in confined membranes, and in membranes subjected to a non-vanishing surface tension. Our results show that confinement may alter significantly the condensation transition of the adhesion bonds, whereas the application of surface tension has a very minor effect on it. We also investigate domain formation in membranes under negative tension which, in free membranes, causes the enhancement of the amplitude of membrane thermal undulations. Our results indicate that in supported membranes, this effect of a negative surface tension on the fluctuation spectrum is largely eliminated by the pressure resulting from the mixing entropy of the adhesion bonds.

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“…In agreement with previous lattice models that include the membrane explicitly (and not via a potential of mean force) [10][11][12], the adhesion sites do not form large clusters when ǫ = 0, which implies that the membrane-mediated interactions alone are not sufficient to allow the formation of large adhesion domains, but they greatly reduce the strength of the residual interactions required to facilitate cluster formation. Following this study, Noguchi suggested that the strength of the membrane-mediated interactions can be enhanced by pinning more than one membrane to the surface [15]. He demonstrated this by simulating monolayers of particles that are pinned to each other by "gap junctions".…”

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confidence: 97%

Coarse-grained molecular simulations of membrane adhesion domains

Dharan

Farago

2014

The Journal of Chemical Physics

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We use a coarse-grained molecular model of supported lipid bilayers to study the formation of adhesion domains. We find that this process is a first order phase transition, triggered by a combination of pairwise short range attractive interactions between the adhesion bonds and many-body Casimir-like interactions, mediated by the membrane thermal undulations. The simulation results display an excellent agreement with the recently proposed Weil-Farago two-dimensional lattice model, in which the occupied and empty sites represent, respectively, the adhesion bonds and unbound segments of the membrane. A second phase transition, into a hexatic phase, is observed when the attraction between the adhesion bonds is further strengthened.

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Entropy-driven aggregation in multilamellar membranes

Cited by 9 publications

References 30 publications

Shape deformation of lipid membranes by banana-shaped protein rods: Comparison with isotropic inclusions and membrane rupture

Shape deformation of lipid membranes by banana-shaped protein rods: Comparison with isotropic inclusions and membrane rupture

Formation of adhesion domains in stressed and confined membranes

Coarse-grained molecular simulations of membrane adhesion domains

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