“…The second law of thermodynamics accounts for the dissipation of energy via entropy production in any process, including the living organisms (Schrödinger, 1944). Organisms manage a combined entropy process in every constituent of their systems, a change in any subsystem affects others and the entire system (Schrödinger, 1944;Luo, 2009;Molnar et al, 2011;Boregowda et al, 2012;Garland, 2013). Entropy generation in organisms was extensively studied (Prigogine and Wiame, 1946;Zotin and Zotina, 1967;Balmer, 1982;Aoki, 1994;Rahman, 2007;Silva and Annamalai, 2008;Silva and Annamalai, 2009;Neto et al, 2010); while some of the recent studies have been focusing explicitly on exercise (Rahman, 2007;Silva and Annamalai, 2008;Silva and Annamalai, 2009;Neto et al, 2010;Henriques et al, 2014) some of them were also referred to as valuable tools in physiology (Muñoz-Diosdado and Galvez-Coyt, 2010;Uehara and Koibuchi, 2011;Davogustto and Taegtmeyer, 2015).…”