“…gives us useful information in the study of complex systems that operate far away from the equilibrium state, as is the case of the heart [30] and enables the distinction of healthy individuals from those who suffer from heart disease [24,31].We clarify that living systems are examples of systems operating far from equilibrium which could be understood as follows (e.g., see [32,33] and references therein): living systems are subject to mass, energy, entropy, and information fluxes across their boundaries. Time irreversibility, which is fundamental property of far from equilibrium systems, is related to the unidirectionality of the energy flow across the boundaries of the system.…”