Entwicklungsgeschichte des menschlichen Wollhaares

Stöhr, Philipp

doi:10.1007/bf02109981

Cited by 39 publications

(17 citation statements)

References 7 publications

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“…The majority of LRCs in the skin resided in a specialized region at the base of the permanent segment of the HF. Known as the bulge, this region was described more than a century ago by histologists (Stohr 1903). Within the ORS, the bulge resides just below the sebaceous gland at a site where the arrector pili muscle attaches to the follicle (Figure 2).…”

Section: The Bulge Stem Cell Nichementioning

confidence: 99%

Epidermal Stem Cells of the Skin

Blanpain

Fuchs

2006

Annu. Rev. Cell Dev. Biol.

731

596

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The skin constantly renews itself throughout adult life, and the hair follicle undergoes a perpetual cycle of growth and degeneration. Stem cells (SCs) residing in the epidermis and hair follicle ensure the maintenance of adult skin homeostasis and hair regeneration, but they also participate in the repair of the epidermis after injuries. We summarize here the current knowledge of epidermal SCs of the adult skin. We discuss their fundamental characteristics, the methods recently designed to isolate these cells, the genes preferentially expressed in the multipotent SC niche, and the signaling pathways involved in SC niche formation, SC maintenance, and activation. Finally, we speculate on how the deregulation of these pathways may lead to cancer formation.

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Section: The Bulge Stem Cell Nichementioning

confidence: 99%

Epidermal Stem Cells of the Skin

Blanpain

Fuchs

2006

Annu. Rev. Cell Dev. Biol.

731

596

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“…The origin of the term "bulge" arguably dates back to observations made in 1876 by Paul Gerson Unna, who described an epithelial swelling ("wulst") in the ORS of developing human hair follicles that is apparent in the embryo but inconspicuous in human adult hair follicles (3,25,26). Others observed that the postnatal anagen hair follicle is derived from the epithelial (germ) sac, which consists of epithelial cells that surround the telogen club hair (25)(26)(27)(28). Unlike adult human hair follicles, adult mouse telogen club hair follicles are retained and rest juxtaposed to the next growing anagen follicle.…”

Section: The Morphologic and Kinetic Definition Of The Bulgementioning

confidence: 99%

Dissecting the bulge in hair regeneration

Myung¹,

Ito²

2012

J. Clin. Invest.

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The adult hair follicle houses stem cells that govern the cyclical growth and differentiation of multiple cell types that collectively produce a pigmented hair. Recent studies have revealed that hair follicle stem cells are heterogeneous and dynamic throughout the hair cycle. Moreover, interactions between heterologous stem cells, including both epithelial and melanocyte stem cells, within the hair follicle are just now being explored. This review will describe how recent findings have expanded our understanding of the development, organization, and regeneration of hair follicle stem cells. At a basic level, this review is intended to help construct a reference point to integrate the surge of studies on the molecular mechanisms that regulate these cells.

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“…The bulge was first described by Unna [12] and Stohr [13] as the site to which the arrector pili muscle attaches and located near the bottom of the permanent por tion of the follicle. The observation that the germ cells incorporate tritiated thymidine and enter mitosis in early anagen is consistent 10 Wilson/Sun/Lavker Follicle Bulge Cells Produce Lower Anagen Follicle with our findings [3,14].…”

Section: Discussionmentioning

confidence: 99%

Cells in the Bulge of the Mouse Telogen Follicle Give Rise to the Lower Anagen Follicle

Wilson

Sun

Lavker

1994

Skin Pharmacol Physiol

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The slow-cycling cells in the bulge of the outer root sheath may represent stem cells for the hair follicle. With each new anagen (growing) phase bulge cells would give rise to a population of transient-amplifying cells which differentiate into outer root sheath and matrix keratinocytes. The lowermost part of the telogen (resting) follicle is composed of bulge cells lying in close proximity to the dermal papilla. In the mouse the first hair follicle growth is characterized by rapid follicular neogen-esis, but the second and third growth cycles follow the normal follicular growth pattern. We have examined activity of cells in the bulge at the onset of anagen (growing phase) in the third hair cycle in Sencar mice, by treating animals at the end of the second telogen with colchicine to localize mitotic activity in the hair follicle. Mitoses were only seen in bulge cells during early anagen. This confirms that they proliferate transiently, solely at the onset of anagen and strongly supports the suggestion that bulge cells are the origin of the whole lower follicle in anagen.

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Entwicklungsgeschichte des menschlichen Wollhaares

Cited by 39 publications

References 7 publications

Epidermal Stem Cells of the Skin

Epidermal Stem Cells of the Skin

Dissecting the bulge in hair regeneration

Cells in the Bulge of the Mouse Telogen Follicle Give Rise to the Lower Anagen Follicle

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