Environment and asthma in adults

Moual, Nicole Le; Jacquemin, Bénédicte; Varraso, Raphäelle; Dumas, Orianne; Kauffmann, F.; Nadif, Rachel

doi:10.1016/j.lpm.2013.06.010

Cited by 22 publications

(28 citation statements)

References 201 publications

(299 reference statements)

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“…Although it is difficult to disentangle chronic from high peak exposure effects, in most of these studies, workers were likely to experience chronic, low to moderate exposure to irritants. Results 11,31,34 are also generally consistent with a predominant role of irritant exposures and the hypothesis of non-allergic mechanisms for workplace exposure to cleaning products, as previously suggested 37,38 . However, very few studies were longitudinal, preventing strong conclusions regarding the role of irritant cleaning products in asthma induction vs. work-exacerbated asthma.…”

Section: Cleaning Agentssupporting

confidence: 86%

Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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Evidence of a causal effect of chronic workplace irritant exposure in new-onset asthma remains limited, mainly because of a lack of longitudinal studies and the difficulty to evaluate irritant exposures. However, recent epidemiological studies strengthen the evidence of an effect of chronic exposure to irritants in work-related asthma. The underlying mechanism remains unknown but may be related to oxidative stress, neurogenic inflammation and dual irritant and adjuvant effects. However, disentangling chronic irritant effects from either acute irritant-induced asthma or immunological low molecular weight agent-induced asthma is difficult for some agents. Further research is needed to improve assessment of irritant exposures and identify biomarkers.

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Section: Cleaning Agentssupporting

confidence: 86%

Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Our findings add to the evidence that household exposures to cleaning products, especially in spray form, may represent an important emerging life course public health issue [2,5]. Our results support the recent recommendations to investigate preventive measures for consumers [10], and to limit both the production and use of household cleaning products in spray form.…”

Section: Agora Correspondence |supporting

confidence: 86%

Use of household cleaning products, exhaled nitric oxide and lung function in females

et al. 2014

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“…One study on SES (defined by parental education) and children's respiratory and allergic symptoms conducted in 13 diverse countries found that lower SES was related to decreased prevalence of allergy to aero-allergens [61]. The association between SES and asthma prevalence and incidence in adults is not well understood and is a matter of debate [62]. However, lower SES seems to be associated with more severe asthma or poorly controlled asthma [62].…”

Section: Discussionmentioning

confidence: 99%

“…The association between SES and asthma prevalence and incidence in adults is not well understood and is a matter of debate [62]. However, lower SES seems to be associated with more severe asthma or poorly controlled asthma [62]. Asthma prevalence was higher in lower SES groups among adults [63] and among children [61].…”

Section: Discussionmentioning

confidence: 99%

Rhinitis, Asthma and Respiratory Infections among Adults in Relation to the Home Environment in Multi-Family Buildings in Sweden

et al. 2014

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Risk factors for rhinitis, asthma and respiratory infections in the home environment were studied by a questionnaire survey. Totally 5775 occupants (≥18 years old) from a stratified random sample of multi-family buildings in Sweden participated (46%). 51.0% had rhinitis in the last 3 months (current rhinitis); 11.5% doctor diagnosed asthma; 46.4% respiratory infections in the last 3 months and 11.9% antibiotic medication for respiratory infections in the last 12 months. Associations between home environment and health were analyzed by multiple logistic regression, controlling for gender, age and smoking and mutual adjustment. Buildings constructed during 1960–1975 were risk factors for day time breathlessness (OR = 1.53, 95%CI 1.03–2.29). And those constructed during 1976–1985 had more current rhinitis (OR = 1.43, 95%CI 1.12–1.84) and respiratory infections (OR = 1.46, 95%CI 1.21–1.78). Cities with higher population density had more current rhinitis (p = 0.008) and respiratory infections (p<0.001). Rented apartments had more current rhinitis (OR = 1.23, 95%CI 1.07–1.40), wheeze (OR = 1.20, 95%CI 1.02–1.41), day time breathlessness (OR = 1.31, 95%CI 1.04–1.66) and respiratory infections (OR = 1.13, 95%CI 1.01–1.26). Living in colder parts of the country was a risk factor for wheeze (p = 0.03) and night time breathlessness (p = 0.002). Building dampness was a risk factor for wheeze (OR = 1.42, 95%CI 1.08–1.86) and day time breathlessness (OR = 1.57, 95%CI 1.09–2.27). Building dampness was a risk factor for health among those below 66 years old. Odor at home was a risk factor for doctor diagnosed asthma (OR = 1.49, 95%CI 1.08–2.06) and current asthma (OR = 1.52, 95%CI 1.03–2.24). Environmental tobacco smoke (ETS) was a risk factor for current asthma (OR = 1.53, 95%CI 1.09–2.16). Window pane condensation was a risk factor for antibiotic medication for respiratory infections (OR = 1.41, 95%CI 1.10–1.82). In conclusion, rhinitis, asthma and respiratory infections were related to a number of factors in the home environment. Certain building years (1961–1985), building dampness, window pane condensation and odor in the dwelling may be risk factors.

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Environment and asthma in adults

Cited by 22 publications

References 201 publications

Do chronic workplace irritant exposures cause asthma?

Do chronic workplace irritant exposures cause asthma?

Use of household cleaning products, exhaled nitric oxide and lung function in females

Rhinitis, Asthma and Respiratory Infections among Adults in Relation to the Home Environment in Multi-Family Buildings in Sweden

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