Environment and women's reproductive health

Caserta, Donatella; Mantovani, Alberto; Marci, Roberto; Fazi, Alessandra; Ciardo, Francesca; Rocca, Cinzia La; Maranghi, Francesca; Mangino, Massimo

doi:10.1093/humupd/dmq061

Cited by 123 publications

(60 citation statements)

References 154 publications

(205 reference statements)

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“…Mammalian fertility is largely affected by environmental factors such as pollutants, nutrition, and physical or psychological stresses [5,23,31]. Among these factors, heat stress impairs early postfertilization development in many in vivo and in vitro studies [7,12,40].…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin colocalization with and action on mitochondria–

Kuroki

Ikeda

Okada

et al. 2013

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin colocalization with and action on mitochondria–

Kuroki

Ikeda

Okada

et al. 2013

J Assist Reprod Genet

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“…In a systematic review (25) evaluating evidence of an association between EDs exposure and women re productive health, articles published until 2010 were not always consistent, in part due to limitations im posed by practical constraints. Reviewers recommen ded the development of appropriate biomarkers in or der to make progress in this field.…”

Section: Introductionmentioning

confidence: 99%

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Bastos

Souza

Filho

et al. 2013

Arq Bras Endocrinol Metab

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Objective: The aim of the study was quantify organochlorine compounds in women seeking for infertility treatment (n = 15) and in spontaneously pregnant ones (n = 21). Materials and methods: A questionnaire was applied regarding lifestyle, occupational and reproductive history. Blood samples were collected from both groups. Results: From the pesticides studied, pp'DDE was detected in 100% of infertile women, at higher mean levels than in pregnant women (3.02 mcg/L vs. 0.88 mcg/L; p = 0.001; power of 69%), without correlation with the etiology of infertility. Levels of the polychlorinated biphenyls (PCBs) were low, with positive samples in 100% in the infertile women for PCBs 138, 153, 180, while in pregnant women, they were 85.7% for congeners 138 and 153. Only PCB180 showed significance, with frequency of 71.4% (p = 0.019). Conclusions:The risk factors for female infertility were: age, consumption of untreated water and of canned foods. Exposure to the most prevalent organochlorine compounds described in literature was confirmed in the study, indicating that pp'DDE may adversely influence female fertility. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Keywords Organochlorine pesticides; polychlorinated biphenyls; female fertility; endocrine disruptors RESUMO Objetivo: O estudo teve como objetivo quantificar as substâncias organocloradas em mulheres buscando tratamento para infertilidade (n = 15) e que espontaneamente engravidaram (n = 21). Materiais e métodos: Foi aplicado questionário considerando estilo de vida, história ocupacional e reprodutiva. Amostras de sangue foram obtidas em ambos os grupos. Resultados: Dos pesticidas, pp'DDE foi detectado em 100% das inférteis, com níveis maiores que nas grávidas (3,02 mcg/L vs. 0,88 mcg/L; p = 0,001; poder 69%), sem correlação na etiologia da infertilidade. Os níveis de detecção das bifenilas policloradas (PCBs) foram baixos, com 100% de positividade das amostras nas inférteis para os PCBs 138, 153, 180, e de 85,7% nas grávidas para os congêneres 138 e 153. Apenas PCB180 mostrou significância na frequência de 71,4% (p = 0,019). Conclusões: Os fatores de risco para infertilidade feminina foram: idade, consumo de água não tratada e alimentos enlatados. A exposição aos organoclorados mais prevalentes descritos na literatura foi confirmada no estudo, indicando que pp'DDE pode influenciar adversamente a fertilidade feminina. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Descritores Pesticidas organoclorados; bifenilas policloradas; fertilidade feminina; desreguladores endócrinos

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“…Higher concentrations of cadmium inhibited activity of the P450scc gene (Smida, Valderrama, Agostini, Furlan & Chedrese, 2004), inhibited progesterone synthesis (Massanyi, Uhrin, Toman, Kovacik & Biro, 1999;Zhang & Jia, 2007), and facilitated changes in cell morphology and cell death (Smida,et al 2004;Kondoh, Araragi, Sato, Higashimoto, Takiguchi & Sato, 2002). Thus, polluting substances, classified as endocrine disruptors, interfere with the endogenous hormone signaling system, leading to impairment of reproductive health (Caserta et al, 2011;Gupta et al, 2010;Zhang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Untitled

Gautam¹,

Chaube²

2018

Turk. J. Fish. Aquat. Sci.

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The aim of the present study was to examine comparative effects of different concentrations of heavy metals such as cadmium (Cd), cobalt (Co), lead (Pb) and mercury (Hg) on catfish oocyte maturation and ovulation. Post-vitellogenic oocytes of the catfish H. fossilis were incubated with heavy metals at concentrations of 0.1, 1.0, 10 and 50ng/ml. Translucent follicles without germinal vesicle and opaque follicles with GV were scored after 4, 8, 16, and 24 hr of incubation. Percentage GV breakdown (GVBD) was calculated as an index of oocyte maturation. The results of present investigation suggested that the effect of heavy metals on oocyte maturation and ovulation was in the order of Pb > Hg >Cd>Co. Pb and Hg showed significant increases (P<0.05) in GVBD and ovulation at all concentrations during 4 and 8hr of the incubation. However, there was a dose -dependent decrease at 16 and 24hr. Cd and Co showed decline in GVBD and ovulation at 16 and 24 hr of the incubation. However, mercury and lead showed a stimulatory effect on ovulation at 16 and 24 hr compared to control (P<0.05). Thus, these results suggest that catfish oocytes are differentially influenced by heavy metals and are resistant to them at certain levels.

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Environment and women's reproductive health

Abstract: A detailed appraisal of compounds specifically related to adverse reproductive outcomes is very important for prevention and risk-communication strategies. Besides research needs, the current evidence is sufficient to prompt precautionary actions to protect women's reproductive health.

Cited by 123 publications

References 154 publications

Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin colocalization with and action on mitochondria–

Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin colocalization with and action on mitochondria–

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

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