Environment enrichment rescues the neurodegenerative phenotypes in presenilins‐deficient mice

Shen, Dong; Li, Chunxia; Wu, Pu; Tsien, Joe Z.; Hu, Yinghe

doi:10.1111/j.1460-9568.2007.05641.x

Cited by 44 publications

(40 citation statements)

References 42 publications

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“…These tests evaluated the bar pressure response as a learning determinant and found a significant improvement in the performance of animals kept in enriched environments. These results corroborate other studies that showed the influence of EE on cognition in rats 17,18 , mice 21,22 , rabbits 23 and pig…”

Section: Discussionsupporting

confidence: 92%

Enriquecimento ambiental como princípio ético nas pesquisas com animais

et al. 2016

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Animals used in experiments have reduced levels of welfare and are thus vulnerable to pain and suffering. Considering that environmental enrichment increases the quality of life of captive animals, we aimed to assess its scientific application regarding the promotion of animal welfare by recognizing the vulnerability of biological models. Documentary analysis and experimental tests were conducted, stating that despite this technique having been applied mainly in neuroscience studies, endorsing their feasibility and the improvement in learning, the rationale for its use has been limited to the successful development of research, that is, not in recognition of animals' vulnerability, their need for welfare and quality of life. In contrast, we proposed the application of environmental enrichment for laboratory animals, within a framework of scientific contractualism and the researcher's responsibility, as a standard to be adopted for the mutual benefit of scientific development and the quality of animal life. Keywords: Bioethics. Bioethics-Enviromental. Animal Experimentation. Scientific misconduct. Psychology Experimental. Resumo Enriquecimento ambiental como princípio ético nas pesquisas com animaisAnimais utilizados em experimentos dispõem de reduzidos meios de bem-estar, estando vulneráveis a dor e sofrimento. Considerando que a técnica de enriquecimento ambiental aumenta a qualidade de vida de animais cativos, objetivou-se avaliar sua aplicação científica no âmbito da promoção de bem-estar por meio do reconhecimento da vulnerabilidade de modelos biológicos. Para tanto, conduziram-se análises documentais e ensaios experimentais, atestando que apesar de a técnica de enriquecimento ambiental ter sido aplicada principalmente em estudos de neurociência, endossando sua viabilidade, e da melhora no aprendizado, a justificativa para sua utilização tem se limitado ao bom desenvolvimento da pesquisa, e não em reconhecimento da vulnerabilidade e necessidade de bem-estar e qualidade de vida do animal. Em contraponto, foi proposta a aplicação do enriquecimento ambiental em animais de laboratório, num âmbito de contratualismo científico e responsabilidade do pesquisador, como norma a ser adotada para benefício mútuo do desenvolvimento científico e qualidade de vida animal. Palavras-chave: Bioética. Bioética-Meio ambiente. Experimentação animal. Má conduta científica. Psicologia experimental. ResumenEl enriquecimiento ambiental como un principio ético en la investigación con animales Los animales utilizados en experimentos disponen de bienestar reducido y están expuestos al dolor y al sufrimiento. Considerando que la técnica de enriquecimiento ambiental aumenta la calidad de vida de los animales en cautiverio, el objetivo de este estudio fue evaluar su aplicación científica en el ámbito de la promoción del bienestar mediante el reconocimiento de la vulnerabilidad de los modelos biológicos. Para ello, se realizaron análisis documentales y ensayos experimentales, señalando que a pesar de que la técnica de enriquecimien...

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Section: Discussionsupporting

confidence: 92%

Enriquecimento ambiental como princípio ético nas pesquisas com animais

et al. 2016

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“…Microarray analysis was performed and analyzed as previously described (Dong et al, 2007;Li et al, 2011). Briefly, the cortex tissues from each group were pooled (5 mice/pool), and total RNA was isolated using the Agilent Total RNA Isolation Mini Kit (Agilent, USA) for cDNA synthesis.…”

Section: Dna Microarray Experimentsmentioning

confidence: 99%

NR2B overexpression leads to the enhancement of specific protein phosphorylation in the brain

Zhang

et al. 2014

Brain Research

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“…There is consolidated evidence to show that the characteristics of the housing environment have a marked influence on the behaviour and welfare of animals, both those raised for biomedical investigation or farm animals (Beattie et al, 2000;Olsen et al, 2002;Laviola et al, 2004;Dong et al, 2007;Brenes et al, 2008). In particular, the provision of straw seems to represent a suitable strategy to alleviate the presence of injurious behaviours in swine (Petersen et al, 1995;Kelly et al, 2000;Guy et al, 2002;Van de Weerd et al, 2006;Studnitz et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal effects of environmental enrichment on behaviour and physiology of pigs reared on an intensive-stock farm

Manciocco

Sensi

Moscati

et al. 2011

Italian Journal of Animal Science

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The aim of this paper was to provide a longitudinal evaluation of the effects of physical enrichments on the behaviour and physiology of intensive stock-farming pigs. Twenty-eight crossbred pigs of both sexes, were exposed to four types of enrichments (hemp ropes, steel chains, plastic balls, rubber hoses) over a period of eleven weeks. This investigation was based on specific abnormal behaviours and physiological indicators, including hematologic parameters. For behavioural score, focal sampling was used with recording of abnormal behaviours (body-, tail-and ear-biting), belly nosing, running, and interaction with objects (for Enriched pigs). The presence of skin injuries was also recorded. In general, the frequency of abnormal behaviours was significantly reduced in the Enriched group. A timerelated profile appeared in the use of the enrichments. Males showed higher occurrence of skin injuries than females. Physiological measurements, such as levels of complement system, white blood cells and neutrophils, were lower in pigs from the Enriched group.Enriched pigs, as a whole, presented much lower levels of serum DHEA-S concentration over two weeks. The findings of this study show the successful provision of appropriate enrichments to encourage behaviours which may result in satisfactory animal oral interaction with the enriching objects, preventing them biting pen-mates. In this respect, the objects proposed were strongly effective in producing changes in behaviour which could mitigate inadequate conditions, such as the relationship between animal body weight and the available space allowance.

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Environment enrichment rescues the neurodegenerative phenotypes in presenilins‐deficient mice

Cited by 44 publications

References 42 publications

Enriquecimento ambiental como princípio ético nas pesquisas com animais

Enriquecimento ambiental como princípio ético nas pesquisas com animais

NR2B overexpression leads to the enhancement of specific protein phosphorylation in the brain

Longitudinal effects of environmental enrichment on behaviour and physiology of pigs reared on an intensive-stock farm

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