Environment-relevant concentrations of cadmium induces necroptosis and inflammation; baicalein maintains gill homeostasis through suppressing ROS/ER stress signaling in common carps (Cyprinus carpio L.)

Li, Xiaojing; Wu, Qian; Chen, Dan; Bai, Yichen; Yang, Yuhong; Xu, Shiwen

doi:10.1016/j.envpol.2023.122805

Cited by 12 publications

(2 citation statements)

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“…Salidroside signi cantly reduced intracellular ROS level and suppressed oxidative stress, and increased SOD activity, which shown protection against ultraviolet (UV) radiation [32] . Baicalein, syringin combined with costunolide, and chitosan -rosmarinic acid conjugates have antioxidant activity [33][34][35] .…”

Section: Discussionmentioning

confidence: 99%

“…According to the references [102][103] and the results of the pre-experiment, the creams of the compound drug were divided into low (0.4% compound drug), medium (0.8% compound drug), and high (1.6% compound drug) dose. Similarly, set VC creams (1.6% VC) and acetyl hexapeptide-8 creams (0.01% acetyl hexapeptide-8) according to the references [33,[104][105][106][107][108] . (2) Establish models of photoaging skin and skin administration treatment Follow Table 2 for speci c steps.…”

Section: Preparation Of Creamsmentioning

confidence: 99%

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Screening active ingredients of traditional Chinese medicine by molecular docking technology and evaluating their reduce skin photoaging activities

Zheng,

Deng,

Huang

et al. 2024

Preprint

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ST Objective: Screening active ingredients of traditional Chinese medicine by molecular docking technology and evaluating their anti-skin photoaging activities. Methods: According to the verification results of molecular docking, the five active ingredients are combined in equal proportion to form a compound drug. In HaCaT photoaging model, the effects of the compound drug on antioxidant, inflammatory factors of NF-κB pathway and cytokines of MAPK pathway were studied by SOD and MDA kits, DCFH-DA fluorescent probe and ELISA assays, respectively. In skin photoaging model, the effects of the compound drug on antioxidant, SASP factors of NF-κB and MAPK pathway were studied by SOD kit, MDA kit, CAT kit and ELISA assays, respectively. Results: The results showed that the compound drug increased SOD activity, decreased MDA content and intracellular ROS, inhibited IL-6 of NF-κB pathway, and inhibited MMP-1 and collagen I of MAPK pathway. The results of HE, Masson and Victoria blue skin staining showed that the compound drug inhibited abnormal thickening of the epidermis, abnormal breaking and accumulation of collagen fibers and elastic fibers, and maintained their orderly arrangement. Meanwhile, the results showed that the compound drug increased SOD and CAT activity, inhibited MDA content, inhibited SASP factors IL-6 and TNF-α of NF-κB pathway, and inhibited SASP factors MMP-1 and collagen I of MAPK pathway. Conclusion: The above results indicate that the active ingredients of the compound drug screened by molecular docking have the potential to reduce skin photoaging.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Creamsmentioning

confidence: 99%