Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999–2004)

Zhuang, Xiaodong; Ni, Ao; Liao, Lingjie; Guo, Yang; Dai, Wei; Jiang, Yunxi; Zhou, Huimin; Hu, Xun; Du, Zhimin; Wang, Xueqin; Liao, Xinxue

doi:10.1016/j.atherosclerosis.2018.01.006

Cited by 36 publications

(22 citation statements)

References 26 publications

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“…A simultaneous investigation focused on predictors in the economic, behavioral, social, and psychological domains from across the life course will help advance our understanding of the importance of these factors as earlier, longer-term predictors of mortality ( 14 ). Such an investigation may potentially reveal important transdisciplinary life course contributors to mortality to inform future investigations, similar to genome-wide association studies (GWASs) ( 15 , 16 ) and environment-wide association studies (EWASs) ( 17 – 19 ) that have revealed specific genetic factors or environmental toxins that are predictive of longevity, ill health, and mortality. Importantly, restricting our analyses to behavioral and social factors from across the life course, including childhood, establishes the importance of factors within these domains to include in future studies of the exposome ( 20 ) or in studies, such as that of Ganna and Ingelsson, which traverse the behavioral and social with the biological and medical sciences.…”

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confidence: 99%

Predicting mortality from 57 economic, behavioral, social, and psychological factors

Puterman

Weiss

Hives

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Behavioral and social scientists have identified many nonbiological predictors of mortality. An important limitation of much of this research, however, is that risk factors are not studied in comparison with one another or from across different fields of research. It therefore remains unclear which factors should be prioritized for interventions and policy to reduce mortality risk. In the current investigation, we compare 57 factors within a multidisciplinary framework. These include (i) adverse socioeconomic and psychosocial experiences during childhood and (ii) socioeconomic conditions, (iii) health behaviors, (iv) social connections, (v) psychological characteristics, and (vi) adverse experiences during adulthood. The current prospective cohort investigation with 13,611 adults from 52 to 104 y of age (mean age 69.3 y) from the nationally representative Health and Retirement Study used weighted traditional (i.e., multivariate Cox regressions) and machine-learning (i.e., lasso, random forest analysis) statistical approaches to identify the leading predictors of mortality over 6 y of follow-up time. We demonstrate that, in addition to the well-established behavioral risk factors of smoking, alcohol abuse, and lack of physical activity, economic (e.g., recent financial difficulties, unemployment history), social (e.g., childhood adversity, divorce history), and psychological (e.g., negative affectivity) factors were also among the strongest predictors of mortality among older American adults. The strength of these predictors should be used to guide future transdisciplinary investigations and intervention studies across the fields of epidemiology, psychology, sociology, economics, and medicine to understand how changes in these factors alter individual mortality risk.

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confidence: 99%

Predicting mortality from 57 economic, behavioral, social, and psychological factors

Puterman

Weiss

Hives

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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show abstract

“…A meta-analysis by Chowdhury et al, encompassing over 300,000 patients, recently reported that lead and cadmium are cardiovascular risk factors with a doseresponse relationship [24]. An environment-wide association analysis by Zhuang et al, in 2018, analyzed the NHANES data for predictors of PAD [25]. Cadmium was one out of only four independently predictive variables.…”

Section: Discussionmentioning

confidence: 99%

Limb Preservation Using Edetate Disodium-based Chelation in Patients with Diabetes and Critical Limb Ischemia: An Open-label Pilot Study

Arenas¹,

Ujueta²,

Diaz³

et al. 2019

Cureus

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“…Epidemiological studies support the association of toxic metals and PAD (2,4). An environmental association study from the National Health and Nutrition Examination Survey identified cadmium as being independently associated with PAD (13). Chronic cadmium exposure accelerates atherosclerosis and increases total cholesterol in animal models (6).…”

Section: Case Presentationmentioning

confidence: 97%

Edetate Disodium–Based Treatment in a Patient With Diabetes and Critical Limb Ischemia After Unsuccessful Peripheral Arterial Revascularizations: A Case Report

et al. 2019

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Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999–2004)

Cited by 36 publications

References 26 publications

Predicting mortality from 57 economic, behavioral, social, and psychological factors

Predicting mortality from 57 economic, behavioral, social, and psychological factors

Limb Preservation Using Edetate Disodium-based Chelation in Patients with Diabetes and Critical Limb Ischemia: An Open-label Pilot Study

Edetate Disodium–Based Treatment in a Patient With Diabetes and Critical Limb Ischemia After Unsuccessful Peripheral Arterial Revascularizations: A Case Report

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