Environmental 24-hr Cycles Are Essential for Health

Lucassen, Eliane A.; Coomans, Claudia P.; Putten, Maaike van; Kreij, Suzanne R. de; Genugten, Jasper H.L.T. van; Sutorius, Robbert P.M.; Rooij, Karien E. de; Velde, M. van der; Verhoeve, Sanne L.; Smit, J.W.A.; Löwik, Clemens W.G.M.; Smits, Hermelijn H.; Guigas, Bruno; Aartsma‐Rus, Annemieke; Meijer, Johanna H.

doi:10.1016/j.cub.2016.05.038

Cited by 113 publications

(104 citation statements)

References 64 publications

(76 reference statements)

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“…Chronic circadian misalignment has been related to metabolic derangements previously [38,39]. For instance, circadian disruption induced by constant light worsened bone microstructure in young mice resembling age-related osteoporosis [40]. Alternatively, effects of sleep time on the musculoskeletal system may be partly explained by behavioral differences.…”

Section: Discussionmentioning

confidence: 99%

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study

et al. 2017

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ContextSleep deprivation has detrimental metabolic consequences. Osteopenia and sarcopenia usually occur together and increase risk of fractures and disease. Results from studies linking sleep parameters to osteopenia or sarcopenia are scarce and inconsistent.ObjectiveTo examine the associations of sleep parameters with osteopenia and sarcopenia, considering the influence of sex and menopause.Design, setting and participantsCross-sectional analysis of 915 participants (45–65 years, 56% women, BMI 26 (range: 18–56) kg/m2) in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. Sleep duration, quality, and timing were assessed with the Pittsburgh Sleep Quality Index (PSQI); bone mineral density and relative appendicular muscle mass were measured by DXA scans. Linear and logistic regressions were performed to associate sleep parameters to bone mineral density, relative appendicular muscle mass, osteopenia (t-score between -1 and -2.5) and sarcopenia (1 SD below average muscle mass).ResultsAfter adjustment for confounding factors, one unit increase in PSQI score (OR and 95% CI, 1.09, 1.03–1.14), declined self-rated sleep quality (1.76, 1.03–3.01), sleep latency (1.18, 1.06–1.31), and a one hour later sleep timing (1.51, 1.08–2.11), but not sleep duration (1.05, 0.90–1.23), were associated with osteopenia. PSQI score (1.10, 1.02–1.19) was also associated with sarcopenia; OR’s of sleep latency and later mid-sleep time with sarcopenia were 1.14 (0.99–1.31) and 1.54 (0.91–2.61), respectively. Associations were somewhat stronger in women and varied per menopausal status.ConclusionsThese results suggest that decreased sleep quality and a later sleep timing are risk factors for osteopenia and sarcopenia in middle aged individuals.

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Section: Discussionmentioning

confidence: 99%

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study

et al. 2017

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“…A six-month period of light exposure induced a number of muscle dysfunctions, including reduced grip strength and grip hanging duration; impairments that were mostly reversed when the animals were returned to a normal day/night cycle. It was proposed that these changes were mediated by changes in SCN neural activity [42]. More work is required to reconcile the acute and sustained impacts that sleep deprivation and/or changes in light exposure has on skeletal muscle, particularly in humans.…”

Section: A Model For Shiftwork and Skeletal Muscle Healthmentioning

confidence: 99%

The Impact of Shiftwork on Skeletal Muscle Health

et al. 2017

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(1) Background: About one in four workers undertake shift rosters that fall outside the traditional 7 a.m.–6 p.m. scheduling. Shiftwork alters workers’ exposure to natural and artificial light, sleep patterns, and feeding patterns. When compared to the rest of the working population, shiftworkers are at a greater risk of developing metabolic impairments over time. One fundamental component of metabolic health is skeletal muscle, the largest organ in the body. However, cause-and-effect relationships between shiftwork and skeletal muscle health have not been established; (2) Methods: A critical review of the literature was completed using online databases and reference lists; (3) Results: We propose a conceptual model drawing relationships between typical shiftwork consequences; altered light exposure, sleep patterns, and food and beverage consumption, and drivers of skeletal muscle health—protein intake, resistance training, and hormone release. At present, there is no study investigating the direct effect of shiftwork on skeletal muscle health. Instead, research findings showing that acute consequences of shiftwork negatively influence skeletal muscle homeostasis support the validity of our model; (4) Conclusion: Further research is required to test the potential relationships identified in our review, particularly in shiftwork populations. Part of this testing could include skeletal muscle specific interventions such as targeted protein intake and/or resistance-training.

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“…In humans, an aberrant eating pattern, such as late night caloric intake, increases the risk of developing coronary heart disease by as much as 55%, after controlling for diet and lifestyle [18]. These observations in humans are now replicated in controlled animal studies [19], lending further support to the notion that chronic circadian disruption contributes to risks for chronic diseases. Conversely, there is growing number of observations that constraining all caloric intake to <12 h can reduce breast cancer risk and improve prognosis [20, 21].…”

Section: Introductionmentioning

confidence: 96%

A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India

2017

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The daily rhythm of feeding-fasting and meal-timing are emerging as important determinants of health. Circadian rhythm research in animal models and retrospective analyses of human nutrition data have shown that reduced length of overnight fasting or increased late night eating increases risk for metabolic diseases including obesity and diabetes. However, the daily rhythm in eating pattern in humans is rarely measured. Traditional methods to collect nutrition information through food diary and food log pay little attention to the timing of eating which may also change from day to day. We adopted a novel cell-phone based approach to longitudinally record all events of food and beverage intake in adults. In a feasibility study daily food-eating patterns of 93 healthy individuals were recorded for 21 days using camera phones. Analysis of the daily eating patterns of these individuals indicates deviation from conventional assumption that people eat three meals-a-day within a 12 h interval. We found that eating events are widespread throughout the day, with <30% of calories consumed before noon and >30% consumed in evening and late night hours. There was little difference in eating pattern between weekdays and weekends. In this cohort more than 50% of people spread their caloric intake events over 15 h or longer. One decile of the cohort who were spouses of shift-workers or had flexible work schedule spread their caloric intake over 20 h. Although the nutrition quality and diversity of food consumed is different between South-East Asian and Western countries, such overall disruption of daily eating-fasting rhythm is similar. Therefore, in view of hypothesis that disrupted daily eating pattern may contribute to the global increase in metabolic diseases and modification of daily eating pattern is a potential modifiable behavior to contain these diseases, monitoring eating pattern is an important aspect of lifestyle.

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Environmental 24-hr Cycles Are Essential for Health

Cited by 113 publications

References 64 publications

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study

The Impact of Shiftwork on Skeletal Muscle Health

A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India

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