Occupational and environmental exposures are important contributors influencing the burden of disease in developing countries. It is important to quantify the impact of exposures from working and living environments on individual and population health in order to reduce the burden of related diseases. Despite the tremendous advances made internationally in the field of exposure science, numerous challenges, including low literacy levels, poor organization of work and living, legislative gaps, and limited exposure science capacity, exist in developing countries. In this commentary, these challenges are discussed and recommendations for the exposure science community to help in addressing the challenges are proposed.