“…In species such as A. thaliana, Populus nigra and Thlaspi arvense, CHH appears to be the most responsive cytosine context to a change in environment (Dubin et al, 2015;Galanti et al, 2022;Peña-Ponton et al, 2022). Conversely, methylation changes in CG context, and to a lesser extent CHG, are extremely stable and more often reflect genomic origin of an individual (Ibañez et al, 2023;Peña-Ponton et al, 2022). However, some studies have suggested that much of the variation in DNA methylation has limited to no functional relevance, regardless of context, as changes in methylome profiles may be but a by-product of genomic or transcriptomic changes (Bewick & Schmitz, 2017;Secco et al, 2015).…”