Environmental and occupational exposure of metals and female reproductive health

Dutta, Sulagna; Gorain, Bapi; Choudhury, Hira; Roychoudhury, Shubhadeep; Sengupta, Pallav

doi:10.1007/s11356-021-16581-9

Cited by 98 publications

(45 citation statements)

References 254 publications

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“…Heavy metals and metallothionein content of mussels and women Figure 1a, depicts the cadmium, lead and metallothionein content of mussels collected from Alexandria coast Egypt. The cadmium content of mussels studied were higher than the EU maximum limits while the lead levels were below the maximum limit [20]. A measurable amount of metallothionein was demonstrated in mussel tissues studied ( gure 1a).…”

Section: Resultsmentioning

confidence: 88%

The role of some heavy metal pollution in idiopathic recurrent spontaneous abortion

El-Sikaily

Helal

Nsonwu-Anyanwu

et al. 2022

Preprint

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Background: Environmental pollution with heavy metal (HM) have been associated with human reproductive failure. Oxidative stress and disruption of homeostatic regulation of reproductive hormones has been implicated in HM induced reproductive toxicity. The HM, indices of oxidative stress, reproductive hormone and red cell indices in women with recurrent pregnancy loss (RPL) in relation to exposure to HM contaminated mussels were assessed in this study. Methods: Seventy-six women (20-35 years) categorized into 18 fertile women without RPL (control group), and Groups I, II and III comprising 24, 18 and 16 women with RPL (2, 3, and >3 abortions respectively) were studied. Whole blood samples were collected for the estimation of cadmium (Cd), lead (Pb), metallothionein (rbcMT), malondialdehyde (MDA), reduced glutathione (GSH), progesterone, haemoglobin (Hb), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). Mussel samples were collected for Cd, Pb and metallothionein (MT) estimation. Results: The cadmium content of mussels were above the maximum limit. Women with RPL (Groups I-III) had higher Cd, Pb, rbcMT and MDA and lower catalase, GSH, P4, Hb, MCV and MCH compared to Group I (p=<0.001). Negative associations were observed between Cd and catalase (r=-0.320, p=0.014), GSH (r=-0.359, p=-0.006) and MCV (r=-0.391, p=-0.002) respectively and between Pb and GSH (r=-0.501, p=<0.001), Hb (r=-0.289, p=0.028), MCV (r=-0.394, p=0.002) and MCH (r=-0.277, p=0.036) respectively in women with RPL. Positive correlations were observed between Cd and Pb (r=0.533, p=<0.001), rbcMT with Cd (r=0.312, p=0.017), Pb (r=0.488, p=<0.000) and MDA (r=0.282, p=0.032) respectively in women with RPL. Conclusion: Elevated cadmium levels in mussels in conjunction with increased HM, metallothionein, MDA and reduced antioxidants, progesterone and red cell indices observed in women with RPL suggest that HM induced oxidative stress and hormonal imbalance may be implicated in recurrent pregnancy loss.

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Section: Resultsmentioning

confidence: 88%

The role of some heavy metal pollution in idiopathic recurrent spontaneous abortion

El-Sikaily

Helal

Nsonwu-Anyanwu

et al. 2022

Preprint

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“…The interference of heavy metals and metalloids on human reproduction ranges from uterine leiomyomata, spontaneous abortions, polycystic ovary syndrome (PCOS), birth defects, endometriosis, abnormal semen quality and functionality, impaired embryogenesis, as well as stillbirths ( 46 , 75 , 79 – 81 ). Recent reports have highlighted the endocrine-disrupting effect of heavy metals and metalloids on the pituitary ovarian axis indicative of their potential associations with female reproductive health ( 82 , 83 ). Heavy metals and metalloids may trigger hormonal changes that alter the menstrual cycle, ovulation, and female fertility ( 84 ).…”

Section: Discussionmentioning

confidence: 99%

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

Obasi

Frazzoli

Orisakwe

2022

Front. Reprod. Health

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Exposures to heavy metals and metalloids have been associated with decreased fecundity and fertility in couples conceiving via assisted reproduction. Heavy metals and metalloids can alter the homeostasis of critical hormones controlling sexual maturation by binding to critical hormones and receptors. This may disrupt the time course of sexual maturation directly or indirectly affecting reproductive competence in males and females. The present review aims to provide a summarized overview of associations between heavy metal exposure, reproductive concerns, and IVF outcomes. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in Google Scholar, Scopus, EMBASE and PubMed databases. Initial search produced 1,351 articles from which 30 articles were eligible to be included in the systematic review. From our results, 16 articles reported associations between selected heavy metals and IVF outcomes, while 14 articles summarized the role of heavy metals in reproductive concerns. For the studies on IVF outcomes, different human samples were examined for heavy metals. Heavy metals and metalloids (Pb, Hg, Cd, Cr, Mn, As) correlated negatively with oocyte fertilization/pregnancy rates in hair, follicular fluid, serum, urine and seminal plasma samples, while Cd and Hg in whole blood samples showed no associations. For the studies on reproductive concerns, high levels of heavy metals/metalloids were implicated in the following conditions: infertility (Cd, Pb, Ba, U), spontaneous abortion/miscarriage (Pb, Cd, Sb), congenital heart disease (Al, Mg, Cd), PCOS (As, Cd, Hg, Pb), endometriosis (Pb) and uterine leiomyomata (Hg). Taken together, the results of our study suggest that the impact of heavy metals and metalloids exposure on reproductive health may contribute to the failure rates of in vitro fertilization.

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“…It can link and stimulate the alpha and beta estrogen receptors and concurrently cause the stimulation of progesterone receptors; thus, it may be designated a probable contributory mediator of estrogen-linked ailments, such as endometrial and breast cancer, endometriosis, and spontaneous abortion [ 26 ]. Pb can directly lead to an elevated risk of impulsive abortion through its possible teratogenic action [ 27 ]. Further, PTEs are probably the agents affecting the neurological system, renal functioning, and ossification process.…”

Section: Major Impacts Of Ptesmentioning

confidence: 99%

Phytoremediation of Potentially Toxic Elements: Role, Status and Concerns

Wani

Ahmad

Asgher

et al. 2023

Plants

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Environmental contamination with a myriad of potentially toxic elements (PTEs) is triggered by various natural and anthropogenic activities. However, the industrial revolution has increased the intensity of these hazardous elements and their concentration in the environment, which, in turn, could provoke potential ecological risks. Additionally, most PTEs pose a considerable nuisance to human beings and affect soil, aquatic organisms, and even nematodes and microbes. This comprehensive review aims to: (i) introduce potentially toxic elements; (ii) overview the major sources of PTEs in the major environmental compartments; (iii) briefly highlight the major impacts of PTEs on humans, plants, aquatic life, and the health of soil; (iv) appraise the major methods for tackling PTE-caused pollution; (v) discuss the concept and applications of the major eco-technological/green approaches (comprising phytoextraction, rhizofiltration, phytostabilization, phytovolatilization, and phytorestoration); (vi) highlight the role of microbes in phytoremediation under PTE stress; and (vii) enlighten the major role of genetic engineering in advancing the phytoremediation of varied PTEs. Overall, appropriate strategies must be developed in order to stop gene flow into wild species, and biosafety issues must be properly addressed. Additionally, consistent efforts should be undertaken to tackle the major issues (e.g., risk estimation, understanding, acceptance and feasibility) in order to guarantee the successful implementation of phytoremediation programs, raise awareness of this green technology among laymen, and to strengthen networking among scientists, stakeholders, industrialists, governments and non-government organizations.

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Environmental and occupational exposure of metals and female reproductive health

Cited by 98 publications

References 254 publications

The role of some heavy metal pollution in idiopathic recurrent spontaneous abortion

The role of some heavy metal pollution in idiopathic recurrent spontaneous abortion

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

Phytoremediation of Potentially Toxic Elements: Role, Status and Concerns

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