Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner

Giacomini, Ana C.V.V.; Abreu, Murilo S. de; Zanandrea, Rodrigo; Saibt, Nathália; Friedrich, Maria Tereza; Koakoski, Gessi; Gusso, Darlan; Piato, Ângelo; Barcellos, Leonardo José Gil

doi:10.1038/srep28986

Cited by 67 publications

(34 citation statements)

References 41 publications

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“…Several lines of evidence support the idea that environmental enrichment can greatly enhance the welfare of animals kept in captivity (Simpson and Kelly, 2011). With regards to fish, the available data suggest that the structural complexity of the rearing environment can alter fish behaviour and exert positive effects on their state of welfare and health by reducing the impact of stress (Pounder et al, 2016) with an effect comparable with that obtained with antidepressant and anxiolytic drug treatments (Giacomini et al, 2016). Moreover, environmental enrichment can increase brain development, enhance cognitive abilities (Salvanes et al, 2013) and improve the foraging skills (Rodewald et al, 2011) of farmed fish, simulating to some extent the spatial component of the ecological niche in the wild.…”

Section: Environmental Complexitymentioning

confidence: 95%

Review: Assessing fish welfare in research and aquaculture, with a focus on European directives

Toni

Manciocco

Angiulli

et al. 2019

Animal

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The number of farmed fish in the world has increased considerably. Aquaculture is a growing industry that will in the future provide a large portion of fishery products. Moreover, in recent years, the number of teleost fish used as animal models for scientific research in both biomedical and ecological fields has increased. Therefore, it is increasingly important to implement measures designed to enhance the welfare of these animals. Currently, a number of European rules exist as requirements for the establishment, care and accommodation of fish maintained for human purposes. As far as (teleost) fish are concerned, the fact that the number of extant species is much greater than that of all other vertebrates must be considered. Of further importance is that each species has its own specific physical and chemical requirements. These factors make it difficult to provide generalized recommendations or requirements for all fish species. An adequate knowledge is required of the physiology and ecology of each species bred. This paper integrates and discusses, in a single synthesis, the current issues related to fish welfare, considering that teleosts are target species for both aquaculture and experimental models in biological and biomedical research. We first focus on the practical aspects, which must be considered when assessing fish welfare in both research and aquaculture contexts. Next, we address husbandry and the care of fish housed in research laboratories and aquaculture facilities in relation to their physiological and behavioural requirements, as well as in reference to the suggestions provided by European regulations. Finally, to evaluate precisely which parameters described by Directive 2010/63/EU are reported in scientific papers, we analysed 82 articles published by European researchers in 2014 and 2015. This review found that there is a general lack of information related to the optimal environmental conditions that should be provided for the range of species covered by this directive.

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Section: Environmental Complexitymentioning

confidence: 95%

Review: Assessing fish welfare in research and aquaculture, with a focus on European directives

Toni

Manciocco

Angiulli

et al. 2019

Animal

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“…Interestingly, zebrafish have been shown to prefer EE even when they are reared in barren conditions (Schroeder et al, 2014). In addition, studies with zebrafish revealed that the EE increased brain size (DePasquale et al, 2016) and proliferation of telencephalic cells (von Krogh et al, 2010), decreased anxiety-like behavior and increased exploration (Manuel et al, 2015), as well as blunting the cortisol response to acute stress in both isolated and group-housed zebrafish (Giacomini et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment modulates the response to chronic stress in zebrafish

Marcon

Mocelin

Benvenutti

et al. 2018

Journal of Experimental Biology

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Several studies have shown that manipulations to the housing environment modulate susceptibility to stress in laboratory animals, mainly in rodents. Environmental enrichment (EE) is one such manipulation that promotes neuroprotection and neurogenesis, besides affecting behaviors such as drug self-administration. Zebrafish are a popular and useful animal model for behavioral neuroscience studies; however, studies evaluating the impact of housing conditions in this species are scarce. In this study, we verified the effects of EE on behavioral (novel tank test) and biochemical [cortisol and reactive oxygen species (ROS)] parameters in zebrafish submitted to unpredictable chronic stress (UCS). Consistent with our previous findings, UCS increased anxiety-like behavior, cortisol and ROS levels in zebrafish. EE for 21 or 28 days attenuated the effects induced by UCS on behavior and cortisol, and prevented the effects on ROS levels. Our findings reinforce the idea that EE exerts neuromodulatory effects across species, reducing vulnerability to stress and its biochemical impact. Also, these results indicate that zebrafish is a suitable model animal to study the behavioral effects and neurobiological mechanisms related to EE.

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“…In rodents, environmental modulation, such as environmental enrichment (EE) or regular exercise, correct various behavioral deficits (Bailoo et al., 2018; Bayne, 2018; Toth, Kregel, Leon, & Musch, 2011), including obsessive‐compulsive disorders (OCD)‐related aggression (Haemisch & Gärtner, 1997; Haemisch, Voss, & Gärtner, 1994) and impulsivity (Binder, Droste, Ohl, & Reul, 2004). Various EE models are currently available in zebrafish (Giacomini et al., 2016; Marcon et al., 2018; Volgin et al., 2018), showing high sensitivity to EE modulation of aggression (Woodward, Winder, & Watt, 2019), sociality (Schroeder, Jones, Young, & Sneddon, 2014) and anxiety‐like behavior (Marcon et al., 2018). Collectively, this suggests that EE‐based aquatic models may also be relevant to ICDs, fostering the search for their biobehavioral therapies.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish models of impulsivity and impulse control disorders

Abreu

Giacomini

Genário

et al. 2020

Eur J of Neuroscience

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Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional‐defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD‐specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.

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Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner

Cited by 67 publications

References 41 publications

Review: Assessing fish welfare in research and aquaculture, with a focus on European directives

Review: Assessing fish welfare in research and aquaculture, with a focus on European directives

Environmental enrichment modulates the response to chronic stress in zebrafish

Zebrafish models of impulsivity and impulse control disorders

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