Environmental and Toxicity Effects of Perfluoroalkylated Substances

Hekster, Floris M.; Laane, R.W.P.M.; Voogt, P. de

doi:10.1007/0-387-21731-2_4

Cited by 293 publications

(216 citation statements)

References 34 publications

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“…Although the toxicity of PFASs has been intensively studied in recent years, most work has been limited to either PFOS or PFOA (Hekster et al 2003;Wang et al 2014b). It is known Fig.…”

Section: Risk Assessment Of Pfass In Water From the Daling Rivermentioning

confidence: 99%

Perfluoroalkyl substances in the Daling River with concentrated fluorine industries in China: seasonal variation, mass flow, and risk assessment

Zhu

Wang

Meng

et al. 2015

Environ Sci Pollut Res

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In the present study, we investigated concentrations and composition profiles of perfluoroalkyl substances (PFASs) in surface water from the Daling River in different seasons. The highest concentration of ΣPFASs (9540 ng L −1 ) and dominant homologues were found in surface water collected in summer. Perfluorobutanoic acid (PFBA), perfluorobutane sulfonate (PFBS), and perfluorooctanoic acid (PFOA) were the dominant PFASs in four seasons with a total contribution of over 90 %. The discharge of two fluorine chemical industry parks was predicted to be the main contamination source of PFASs in the study area. The daily and annual mass flows were calculated according to data of detected PFAS concentrations and water discharge, and the annual mass loading of PFASs into the Bohai Sea from the Daling River reached to 461 kg year −1 . Hazard assessment indicated that concentrations of PFASs in study area had little risk to aquatic organisms and wildlife. However, the multiple health risk would be relatively high if the water was served as drinking water in the study area.

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“…Although the toxicity of PFASs has been intensively studied in recent years, most work has been limited to either PFOS or PFOA (Hekster et al 2003;Wang et al 2014b). It is known Fig.…”

Section: Risk Assessment Of Pfass In Water From the Daling Rivermentioning

confidence: 99%

Perfluoroalkyl substances in the Daling River with concentrated fluorine industries in China: seasonal variation, mass flow, and risk assessment

Zhu

Wang

Meng

et al. 2015

Environ Sci Pollut Res

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“…Because of their specific physical and chemical properties, chemical and thermal inertness, low surface energy, and special surface-active properties, PFAAs have applications in numerous industrial and consumer products, ranging from carpet protection to firefighting foams (Lehmler 2005;Martin et al 2004). PFAAs persist ubiquitously in the environment, resisting hydrolysis, photolysis, and biodegradation because of the high energy of the carbon-fluorine bond (Hekster et al 2003;Martin et al 2004;Quinete et al 2010). Although the toxicological effects of these chemicals are still under investigation, many studies have reported on their developmental and reproductive toxicity, neurotoxicity, immunotoxicity, and carcinogenicity in animals both in vivo and in vitro (Hekster et al 2003;Lau et al 2004;Slotkin et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…PFAAs persist ubiquitously in the environment, resisting hydrolysis, photolysis, and biodegradation because of the high energy of the carbon-fluorine bond (Hekster et al 2003;Martin et al 2004;Quinete et al 2010). Although the toxicological effects of these chemicals are still under investigation, many studies have reported on their developmental and reproductive toxicity, neurotoxicity, immunotoxicity, and carcinogenicity in animals both in vivo and in vitro (Hekster et al 2003;Lau et al 2004;Slotkin et al 2008). PFAAs can cause peroxisomal proliferation, mitochondrial dysfunction, disturbance of fatty acid metabolism, hepatocellular hypertrophy, changes in membrane surface potential, and changes in gene expression levels (Hekster et al 2003;Hu et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Although the toxicological effects of these chemicals are still under investigation, many studies have reported on their developmental and reproductive toxicity, neurotoxicity, immunotoxicity, and carcinogenicity in animals both in vivo and in vitro (Hekster et al 2003;Lau et al 2004;Slotkin et al 2008). PFAAs can cause peroxisomal proliferation, mitochondrial dysfunction, disturbance of fatty acid metabolism, hepatocellular hypertrophy, changes in membrane surface potential, and changes in gene expression levels (Hekster et al 2003;Hu et al 2002). Perfluorooctanoic acid (PFOA) and perfluorodecanoic acid are known to induce biogenesis of liver peroxisomes and significantly affect liver phospholipid metabolism (Adinehzadeh and Reo 1998).…”

Section: Introductionmentioning

confidence: 99%

“…The down-regulation of intercellular communications by peroxisome proliferators results in abnormal cell growth and increases tumorigenicity (Trosko and Ruch 1998). Therefore, PFAAs, such as perfluorooctane sulfonate (PFOS), PFOA, and perfluorooctanesulfonyl fluoride (PFOSF), have many negative effects in the environment and have been identified as new persistent organic pollutants (Hekster et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Study on the binding interaction between perfluoroalkyl acids and DNA

Cao

Wei

Cheng

2013

Environ Sci Pollut Res

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Perfluoroalkyl acids (PFAAs) are carcinogens, and elucidating their DNA binding properties is crucial for understanding PFAA genotoxicity. We have investigated the binding mode and affinity of five PFAAs to seven DNA molecules using fluorescence displacement and molecular docking analysis. DNA conformational changes upon PFAA binding were also examined by circular dichroism (CD). The data revealed that DNA intercalation was the dominant interaction mode of the PFAAs; however, these molecules also bound to grooves. The dissociation constants for the PFAAs ranged between 0.11 and 1,217.14 μM, and between 3.46 and 2,141.21 μM for DNA intercalation and groove binding, respectively. PFAAs that contain longer carbon chains had stronger DNA intercalation affinities. Binding to DNA was stronger for perfluoroalkyl sulfonates than for perfluorcarboxyl acids that contain the same number of carbons. This observation is postulated to arise from the presence of more fluorine and oxygen atoms in perfluoroalkyl sulfonates acting as hydrogen bond donors that facilitate stronger DNA intercalation. The binding of the PFAAs to DNA showed some CT-DNA sequence selectivity. Molecular docking analysis confirmed the DNA binding mode and affinities of the PFAAs. CD analysis revealed that the PFAAs weakened DNA base stacking and loosened DNA helicity. The present study has improved our understanding of the formation of PFAA-DNA adducts.

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Profiling research on PFAS in wildlife: Protocol of a systematic evidence map and bibliometric analysis

Vendl

Taylor

Bräunig

et al. 2021

Ecol Sol and Evidence

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1. Per-and polyfluoroalkyl substances (PFAS) are a large group of manufactured chemicals. Since the beginning of their commercial production in the 1950s, PFAS have not only found their way into numerous industrial and commercial applications, but also into the bloodstream of much of the human population, the natural environment and wildlife. Exposure to high levels of PFAS poses a health risk for humans and animals, and may exacerbate the effects of other anthropogenic impacts faced by wildlife species. To gain a comprehensive overview of the abundance and distribution of PFAS research on wildlife species, and to better understand the drivers of this research, we will collate the available literature into a systematic evidence map and perform bibliometric analyses. The systematic mapping will present the distribution of research evidence that exists on PFAS in wildlife.The bibliometric analysis will provide an insight into the historical trends, interdisciplinarity, connectedness and the impact of the individual papers.2. We will conduct a systematic literature search on Scopus, Web of Science and 10 other databases using predefined search strings. We will screen title, abstract and keywords first. We will then screen full-text papers. Two reviewers will be involved in the screening process. We will only consider publications in English, peer-reviewed articles, preprints and theses. We will include papers reportingThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Environmental and Toxicity Effects of Perfluoroalkylated Substances

Cited by 293 publications

References 34 publications

Perfluoroalkyl substances in the Daling River with concentrated fluorine industries in China: seasonal variation, mass flow, and risk assessment

Perfluoroalkyl substances in the Daling River with concentrated fluorine industries in China: seasonal variation, mass flow, and risk assessment

Study on the binding interaction between perfluoroalkyl acids and DNA

Profiling research on PFAS in wildlife: Protocol of a systematic evidence map and bibliometric analysis

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