Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management

Rahaman, Md. Shiblur; Rahman, Md. Mostafizur; Mise, Nathan; Sikder, Md. Tajuddin; Ichihara, Gaku; Uddin, Md. Khabir; Kurasaki, Masaaki; Ichihara, Sahoko

doi:10.1016/j.envpol.2021.117940

Cited by 344 publications

(125 citation statements)

References 211 publications

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“…For example, more than 200 million persons worldwide are exposed to arsenic, which has been demonstrated to induce oxidative stress. This can lead to the death and dysfunction of beta-cells, thus weakening blood glucose control and increased insulin resistance in affected individuals [72]. Findings such as the above mentioned, demonstrate that biological processes should be considered as open systems exhibiting a complex interplay with their associated environment.…”

Section: Environment and T1dmentioning

confidence: 99%

“…Researchers classify exposures into three categories: internal exposures, arising from endogenous pathways; external exposures such as infections, diet, and substance use; and general external exposures that broadly include the geography and climate a person lives in, socioeconomic status, and the psychosocial environment [13]. Although the environment of a given individual is dynamic, studies using metabolomic data have shown associations with environmental factors such as the gut microbiome [72]. Additionally, Passero et al found that environmental risk scores for oxidative stress were associated with cardiovascular phenotypes [71].…”

Section: Environment and T1dmentioning

confidence: 99%

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Recent Advances of Integrative Bio-Omics Technologies to Improve Type 1 Diabetes (T1D) Care

et al. 2021

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Type 1 diabetes (T1D) is a complex autoimmune disease that currently cannot be cured, only managed. Optimal treatment the of T1D symptoms, requires a multidisciplinary care team, including endocrinologists, educators, primary care providers, health care specialists, genetic counselors, and data scientists. This review summarizes how an integrative approach to T1D drives innovation and quality improvements in health care. Specifically, we highlight how “-omics” technologies facilitate the understanding of different aspects of the disease, including prevention, pathogenesis, diagnostics, and treatment. Furthermore, we explore how biological data can be combined with personal and electronic health records to tailor medical interventions to the individual’s biology and lifestyle. We conclude that truly personalized medicine will not be limited to one data source but will emerge from the integration of multiple sources and disciplines that together will support individuals with T1D in their everyday life.

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Section: Environment and T1dmentioning

confidence: 99%

Section: Environment and T1dmentioning

confidence: 99%

Recent Advances of Integrative Bio-Omics Technologies to Improve Type 1 Diabetes (T1D) Care

et al. 2021

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“…This metalloid has been classified in the Group 1 of carcinogenic compounds for humans by the International Agency of Research on Cancer (IARC, 2004) [48]. Exhaustive research has demonstrated that both acute and chronic exposure to As caused diverse and severe human disorders, that have been extensively reviewed in recent years [49][50][51][52]. Due to the high toxicity of this element, the World Health Organization [53] established 10 µg/L as the maximum safe level in drinking water in its provisional guideline for As, which is in accordance with the suggested total 15 µg of inorganic As intake per kilogram of body weight.…”

Section: Anthropogenic As a Global Environmental Problem With Health Risksmentioning

confidence: 99%

Interactions with Arsenic: Mechanisms of Toxicity and Cellular Resistance in Eukaryotic Microorganisms

Francisco

Martín‐González

Rodríguez-Martín

et al. 2021

IJERPH

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Arsenic (As) is quite an abundant metalloid, with ancient origin and ubiquitous distribution, which represents a severe environmental risk and a global problem for public health. Microbial exposure to As compounds in the environment has happened since the beginning of time. Selective pressure has induced the evolution of various genetic systems conferring useful capacities in many microorganisms to detoxify and even use arsenic, as an energy source. This review summarizes the microbial impact of the As biogeochemical cycle. Moreover, the poorly known adverse effects of this element on eukaryotic microbes, as well as the As uptake and detoxification mechanisms developed by yeast and protists, are discussed. Finally, an outlook of As microbial remediation makes evident the knowledge gaps and the necessity of new approaches to mitigate this environmental challenge.

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“…YeonRoh et al [ 13 ] demonstrated that the mtl-2 ( gk125 ) had the lowest LC50 among mutant strains when exposed to Cd, showing significantly less egg production and increased expression of mtl-2 gene. Arsenic has multiple species with different toxicity in As(III) > As(V) > Dimethylarsinic Acid (DMA) > Monomethylarsonic Acid (MMA) order, indicating a higher risk from inorganic As than organic As [ 14 , 15 ]. It has a significant impact on human health, causing cardiovascular diseases, neurobehavioral disorders, hematological disorders, and various types of diseases [ 16 ], by blocking DNA repair and apoptosis, stimulating angiogenesis, causing cell cycle arrest, and inducing aneuploidy [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans

Pei

Sun

Zhao

et al. 2022

Toxics

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Cadmium (Cd) and arsenic (As) are widely distributed pollutants that co-exist in the environment; however, their joint toxicity on living organisms is still largely unknown. In this study, we explored the joint toxicity of concurrent exposure to Cd and different As species at low concentrations on Caenorhabditis elegans (C. elegans) in comparison to single exposures. Endpoints such as germ cell apoptosis, the number of oocytes, brood size, and the life span were employed to evaluate the combined effects of Cd and As on exposed C. elegans from L3 or L4 stages. Our results showed that concurrent exposure to non-toxic concentrations of Cd and As caused the synergy of reproductive and developmental toxicity. The presence of Cd promoted the accumulation of As in both germline and intestine detected by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Although a conversion of As(III) to As(V) was detected as dependent on pH according to the microenvironment of the intestine in the worm, there was no significant difference of toxicity in C. elegans concurrently exposed to Cd and different As species. Using loss-of-function mutant strains, As was deemed responsible for the enhanced joint toxicity, and in which gcs-1 played a key protective role. These data help to better evaluate the comprehensive adverse effects of concurrent exposure of heavy metals at low concentrations on living organisms in the environment.

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Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management

Cited by 344 publications

References 211 publications

Recent Advances of Integrative Bio-Omics Technologies to Improve Type 1 Diabetes (T1D) Care

Recent Advances of Integrative Bio-Omics Technologies to Improve Type 1 Diabetes (T1D) Care

Interactions with Arsenic: Mechanisms of Toxicity and Cellular Resistance in Eukaryotic Microorganisms

Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans

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