Environmental cadmium exposure perturbs systemic iron homeostasis via hemolysis and inflammation, leading to hepatic ferroptosis in common carp (Cyprinus carpio L.)

Guo, Wenli; Zhang, Jinjin; Zhang, Xiaoqian; Ren, Quanzhong; Zheng, Guangzhe; Zhang, Jianxin; Nie, Guoxing

doi:10.1016/j.ecoenv.2024.116246

Cited by 2 publications

(1 citation statement)

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“…Antioxidant enzymes can resist oxidative stress injury through scavenging free radicals caused by ROS ( Amorim et al, 2022 ). Several toxicological studies have manifested that Cd exposure caused kidney injury, including oxidative stress, DNA damage, inflammation responses, membrane destruction and disturbance in metabolism ( Guo et al, 2024 ; Sun et al, 2024 ). Inflammation is generally considered an essential reaction in the toxicology of many environmental toxicants, and can cause damage to the functional and structural integrity of tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Wang,

Zhang,

Ali

et al. 2024

Poultry Science

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Section: Introductionmentioning

confidence: 99%

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Wang,

Zhang,

Ali

et al. 2024

Poultry Science

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Toxic Effects of Cadmium Exposure on Hematological and Plasma Biochemical Parameters in Fish: A Review

Yu,

Lee,

et al. 2024

Toxics

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Cadmium (Cd) is a non-essential trace element that poses significant toxic effects on fish. This review focuses on hematological and plasma biochemical parameters as key indicators of fish health under Cd exposure. Hematological parameters, such as red blood cell (RBC) count, hemoglobin (Hb) concentration, and hematocrit (Ht), were selected for their critical role in oxygen transport and their sensitivity to Cd-induced disruptions, which often result in anemia and impaired oxygen delivery to tissues. Mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) provide further insights into erythropoiesis and hemoglobin synthesis, both of which are essential for assessing Cd toxicity. Plasma biochemical parameters, including calcium, magnesium, glucose, cholesterol, total protein, and liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), are crucial for understanding ionic balance, metabolic regulation, and organ function, especially in fish exposed to Cd. These biomarkers offer a comprehensive view of the physiological stress and organ damage caused by Cd toxicity. This review synthesizes literature findings on the toxic effects of Cd on these parameters. It also discusses potential mitigation strategies, including dietary supplementation with antioxidants and trace elements, to counteract the harmful effects of Cd exposure.

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Environmental cadmium exposure perturbs systemic iron homeostasis via hemolysis and inflammation, leading to hepatic ferroptosis in common carp (Cyprinus carpio L.)

Cited by 2 publications

References 64 publications

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Toxic Effects of Cadmium Exposure on Hematological and Plasma Biochemical Parameters in Fish: A Review

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