Environmental cadmium positively correlates with autophagy and apoptosis in chronic obstructive pulmonary disease patients

Wang, Lixiang; Fei, Jun; Wang, Xinming; Xie, Guo-Fang; Cao, Peng; Zhang, Chen; Zhao, Hui; Fu, Lin; Cao, Wei

doi:10.1016/j.apr.2021.101275

Cited by 11 publications

(2 citation statements)

References 35 publications

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“…In vivo experiment also validates that chronic Cd exposure evokes EMT in mice lungs of COPD model [42]. Meanwhile, earlier research suggests that blood Cd concentration is positively associated with the expressions of autophagy and apoptosis in COPD patients [41]. Animal experiment finds Cd exposure can incur autophagy and apoptosis in lungs [39,46].…”

Section: Discussionmentioning

confidence: 57%

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Association of blood cadmium concentration with chronic obstructive pulmonary disease progression: a prospective cohort study

Sun,

Deng,

et al. 2024

Respir Res

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Background Prior studies in patients with chronic obstructive pulmonary disease (COPD) had indicated a potential correlation between cadmium (Cd) exposure and reduction in lung function. Nevertheless, the influence of Cd exposure on the progression of COPD remained unknown. Exploring the relationship between Cd exposure and the progression of COPD was the aim of this investigation. Methods Stable COPD patients were enrolled. Blood samples were collected and lung function was evaluated. Regular professional follow-ups were conducted through telephone communications, outpatient services, and patients' hospitalization records. Results Each additional unit of blood Cd was associated with upward trend in acute exacerbation, hospitalization, longer hospital stay, and death within 2 years. Even after adjusting for potential confounding factors, each 1 unit rise in blood Cd still correlated with a rise in the frequencies of acute exacerbation, longer hospital stay, and death. Moreover, COPD patients with less smoking amount, lower lung function and without comorbidities were more vulnerable to Cd-induced disease deterioration. Conclusion Patients with COPD who have higher blood Cd concentration are susceptible to worse disease progression. Graphical Abstract

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Section: Discussionmentioning

confidence: 57%

“…Chronic obstructive pulmonary disease (COPD) is characterized by ongoing respiratory difficulties, restricted airflow, and a variety of general symptoms [22,41]. This disease is prevalent globally and poses substantial financial and medical burdens, with projections indicating a further increase in the near future [23].…”

Section: Introductionmentioning

confidence: 99%