Environmental chemicals and human neurotoxicity: magnitude, prognosis and markers

Anetor, JI; Anetor, G.O.; Iyanda, A. A.; Adeniyi, F. A. A.

doi:10.4314/ajbr.v11i1.50675

Cited by 15 publications

(21 citation statements)

References 31 publications

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“…Biomarkers of susceptibility. 16 General Mechanism 16 DNA might be utilized as a file for cell multiplication and cell number in nervous tissues. For instance in the assessment of the impact of lead during early development, there is a decrease in brain weight and a reduction in total brain protein without an adjustment in the number of brain cells.…”

Section: Biomarkersmentioning

confidence: 99%

Mechanism and biomarkers for neurodegenerative diseases: A systematic review

Nandini¹,

Sonar²,

Hemalatha³

et al. 2020

IJN

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Neurodegenerative disease such as Parkinson's disease (PD), Alzheimer's disease (AD), Multiple sclerosis (MS), Huntington's disease (HD) are characterized by progressive loss of cognitive function, dementia and problems with movement. Neuronal loss is associated with extra and intercellular accumulation of misfolding proteins, oxidative stress, free radical formation, mitochondrial dysfunction, disruption of neuronal golgi apparatus, impaired bioenergetics, dysfunction of neurotrophins. Biomarkers that might aid in the diagnosis of these devastating and globally important disease are urgently sought and required. Therefore, range of biomarkers are explained for neurodegenerative disease.

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Section: Biomarkersmentioning

confidence: 99%

Mechanism and biomarkers for neurodegenerative diseases: A systematic review

Nandini¹,

Sonar²,

Hemalatha³

et al. 2020

IJN

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“…The male reproductive system is known to be highly sensitive to some physical and chemical environmental exposures (Severer and Hassel, 1985). Simple biomarkers like urinary creatine may serve as early warning sign (Anetor et al, 2000).…”

Section: Lead Toxicity: a Prime Example Of Environmental Pollutionmentioning

confidence: 99%

Molecular epidemiology: A better approach for the early detection of pathophysiologic response to environmental toxicants and disease

Anetor¹,

Adeniyi²,

Olaleye³

2010

African Journal of Biomedical Research

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Our environment is becoming increasingly contaminated by a profusion of substances in the form of industrial and Municipal Waste, air and water pollutants; by heavy metals (such as lead) herbicides, pesticides, cosmetics and so on. The number of chemicals that affect man increases at alarming rates. These agents may be dangerous because they produce biochemical, genetic, structural or physiological lesions in a significant segment of the population. The importance of elucidating the nature and the mechanisms of physiological and toxicological reactions has been emphasized in the investigations of occupational and environmental diseases, such investigations have revealed that the clinical manifestations of intoxication may have their origin in injurious effects of subcellular or biochemical types. Slight to moderate derangements in metabolism may impair the functional activity of organs and lead to subclinical or overt clinical effects. These may elude detection or recognition of their health implications unless biomarkers, the functional components of molecular epidemiology are employed. Molecular epidemiology is an approach which aims to examine aetiology of disease in a more precise way by focusing on biomarkers of disease risk rather than relying on the actual occurrence of disease. Such studies can be carried out in a short time and with relatively small numbers of subjects compared with conventional epidemiology, which though currently more popular merely reveals association, and causal links often remain obscure. Detection of early biochemical lesions that are related to subsequent changes in structure and physiology would be useful as early indicators of environmental hazards that produce disease in humans, that is by employing molecular epidemiology. This will be greatly enhanced by newer tools, such as toxicogenomics and metabonomics.

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“…The neuronal networks, synaptic plasticity, and newly generated neurons in hippocampal CA1 pyramidal neurons, containing ERβ, have major role in function of learning and memory and novelty detection, so that, any damage in these networks can affect the cognitive performance [25,26]. BPA can easily pass across the blood brain barrier (BBB), inhibits the proliferation and differentiation of neural and oligodendrocyte progenitor cells, and disrupts the DG formation and the myelination process in the rat hippocampal and prefrontal region [27][28][29], leading to neurotoxicity [30] in different life stages and species [31].…”

Section: Introductionmentioning

confidence: 99%

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

Fallahnezhad

Ghorbani-Taherdehi

Nadim

et al. 2021

Preprint

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ObjectiveBisphenol A (BPA) is an endocrine-disrupting chemical that widely used in plastics production. It can influence on the brain tissue. Curcumin has a strong protective activity against brain disorders. The purpose of this study was to evaluate the protective effect of nanomicelle curcumin (NmCur) on BPA-induced learning and memory disorders in rats.Material and methodsIn this study, after determining the dose of BPA, rats were randomly divided into 8 groups (8 rats in each group); sesame oil, dextrose 5%, sesame oil + dextrose 5%, NmCur (50 mg/kg), BPA (50 mg/kg), and 50 mg/kg BPA plus 10, 25, or 50 mg/kg NmCur, respectively. All materials administered via gavage. Behavioral tests were estimated by shuttle-box, open-field, and Morris water maze devices. Then, stress oxidative, pro-inflammatory cytokines, oxidative stress-scavenging enzymes levels, as well as expression of MAPK proteins, glutamate receptors, and memory-related proteins were determined in the hippocampus and cortex tissues. ResultsBPA significantly increased expression of ROS, MDA, TNF-α, IL-6, IL-1β, SOD, GST, p-P38, and p-JNK; however, considerably decreased GSH, GPx, GR, CAT, p-AKT, p-ERK1/2 levels. In addition, it down regulated expression of p-NR1, p-NR2A, p-NR2B, p-GluA1, BDNF, and p-CREB in rat cortex and hippocampus tissues. BPA significantly also changed behavioral activity. Conversely, BPA (50 mg/kg) plus NmCur (25 and 50 mg/kg) significantly reversed all BPA-induced adverse effects. ConclusionThe results of this study support that nanomicelle curcumin exhibited preventive effects against neurotoxicity and learning and memory impairment induced by subacute exposure to bisphenol A.

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Environmental chemicals and human neurotoxicity: magnitude, prognosis and markers

Abstract: ABSTRACT

Cited by 15 publications

References 31 publications

Mechanism and biomarkers for neurodegenerative diseases: A systematic review

Mechanism and biomarkers for neurodegenerative diseases: A systematic review

Molecular epidemiology: A better approach for the early detection of pathophysiologic response to environmental toxicants and disease

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

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