Environmental concentrations of antibiotics alter the zebrafish gut microbiome structure and potential functions

Effect of Chronic Exposure to Textile Wastewater Treatment Plant Effluents on Growth Performance, Oxidative Stress, and Intestinal Microbiota in Adult Zebrafish (Danio rerio)

“…Among these, Actinobacteria, Proteobacteria, Planctomycetes, and Firmicutes were the major phyla in the gut of the control and treatment groups, accounting for 85.85 and 87.59% of the total abundance, respectively, indicating the crucial role of core intestinal microbiota in generalized zebrafish. The results are in accordance with those of previous studies on the gut microbiota of zebrafish ( Bao et al, 2020 ; Kayani et al, 2021 ). Similar results were found in the water samples of aerated tap water and TWTP effluent exposures of 79.79 and 70.64%, respectively.…”

“…Aquatic organisms are exposed to pollutants through ingestion of TWTP effluents, which may alter the microbiota composition in their intestines ( Licht and Bahl, 2019 ). Dysbiosis of the gut microbiome may lead to the onset of various diseases in host organisms ( Duan et al, 2020 ; Kayani et al, 2021 ). The correlation between several diseases and changes in the composition of intestinal microbiota has been reported ( Bajaj and Khoruts, 2020 ; Sun et al, 2021 ).…”

Genome-Resolved Characterization of Structure and Potential Functions of the Zebrafish Stool Microbiome

“…Whole metagenome shotgun sequencing (MGS)-based surveys of zebrafish stool microbiome can provide more accurate and descriptive insights into the taxonomic diversity and functional potential. In a recent effort, Kayani et al., 2021b exposed the zebrafish to different environmental concentrations (much lower than therapeutic concentrations) of oxytetracycline and sulfamethoxazole from the larval stage to adulthood (~120 days). They highlighted the differences between control and exposed groups using MGS ( Kayani et al., 2021b ).…”

“…In a recent effort, Kayani et al., 2021b exposed the zebrafish to different environmental concentrations (much lower than therapeutic concentrations) of oxytetracycline and sulfamethoxazole from the larval stage to adulthood (~120 days). They highlighted the differences between control and exposed groups using MGS ( Kayani et al., 2021b ). In addition, Gaulke et al.…”

Host‐associated Bacillus siamensis and Lactococcus petauri improved growth performance, innate immunity, antioxidant activity and ammonia tolerance in juvenile Japanese seabass ( Lateolabrax japonicus )

“…In the past decades, the L. japonicus culture and even the whole aquaculture system have gradually shifted to intensive and high-density farming, which often accompanied by environmental stress and enhanced risk of disease outbreaks, resulting in massive mortalities and economic loss. Chemical additives and veterinary medicines, especially antibiotics, have been traditionally used as disease control strategy, but excessive or non-selective use of antibiotics is usually associated with a series of problems, such as killing beneficial bacteria (Blaser, 2016;Sahu et al, 2008), microbiota dysbiosis in aquaculture environment and/or host (Almeida et al, 2019;Kayani et al, 2021), antibiotic accumulation in edible products (Limbu et al, 2018;Yuan et al, 2019), and the enhanced resistance of pathogenic bacteria (Syrova et al, 2018). To reduce the abuse of antibiotics, therefore, it is necessary to explore eco-friendly stress and disease control approaches, which will be beneficial to promote healthy and sustainable development of aquaculture.…”