2015
DOI: 10.1007/s00213-015-4031-x
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Environmental condition alters amphetamine self-administration: role of the MGluR5 receptor and schedule of reinforcement

Abstract: Rationale Evidence suggests that differential rearing influences the function of a receptor subtype critical for maintaining glutamate homeostasis. Maintaining homeostatic glutamatergic function may be an important protector against drug abuse. Objective This study sought to determine if differential rearing influences the function of a receptor critical for glutamate homeostasis, which could in turn affect rates of amphetamine self-administration. Methods Rats were assigned to enriched (EC), isolated (IC)… Show more

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Cited by 14 publications
(17 citation statements)
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References 58 publications
(107 reference statements)
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“…Across 10 sessions, acquisition of amphetamine (0.1 mg/kg/ infusion) self-administration was not affected by either environmental condition, F(2, 36) ϭ 1.00, p ϭ .378, 2 ϭ .05 or HDAC inhibition, F(1, 36) ϭ 0.55, p ϭ .464, 2 ϭ .02, data not shown. Consistent with previous research (Arndt et al, 2015;Bardo et al, 2001), differential rearing did not alter self-administration of a high dose of amphetamine and therefore it is not surprising that TsA did not differentially alter responding.…”
Section: Experiments 1: Acquisition and Maintenance Of Amphetamine Se...supporting
confidence: 89%
“…Across 10 sessions, acquisition of amphetamine (0.1 mg/kg/ infusion) self-administration was not affected by either environmental condition, F(2, 36) ϭ 1.00, p ϭ .378, 2 ϭ .05 or HDAC inhibition, F(1, 36) ϭ 0.55, p ϭ .464, 2 ϭ .02, data not shown. Consistent with previous research (Arndt et al, 2015;Bardo et al, 2001), differential rearing did not alter self-administration of a high dose of amphetamine and therefore it is not surprising that TsA did not differentially alter responding.…”
Section: Experiments 1: Acquisition and Maintenance Of Amphetamine Se...supporting
confidence: 89%
“…Our study is the first to show changes in the mGlu 5 receptor density and affinity due to housing conditions following exposure to cocaine. So far, limited research has been conducted to study the EE and IC on mGlu 5 receptors, and our findings show that both of the above-mentioned conditions alter the function of receptors critical for maintaining glutamate homeostasis, which can lead to altered drug-taking behaviours (Arndt et al, 2015).…”
Section: Discussionmentioning
confidence: 89%
“…The current experiment did not examine if a similar relationship exists between housing condition and novelty during psychostimulant self-administration. An extensive literature indicates that the novelty response predicts the acquisition of low unit doses of psychostimulants (Piazza et al, 1989; Piazza et al, 1990), and that enrichment decreases the self-administration of low unit doses of amphetamine (Arndt et al, 2015; Bardo et al, 2001). Therefore, we hypothesize that a similar mediation pattern between novelty and housing conditions would remain during self-administration of low unit doses.…”
Section: Discussionmentioning
confidence: 99%
“…Our EC, IC, and SC environmental conditions have been explained previously articles (Arndt et al, 2014; Arndt et al, 2015; Cain et al, 2012; Gill et al, 2012) Briefly, rats in the EC were housed in a large metal cage (60×120×45 cm) that was lined with paper pulp bedding. The EC cage contained 8–12 other rats and contained 14 objects (toys, PVC pipe).…”
Section: Methodsmentioning
confidence: 99%