Environmental conditions that influence toxin biosynthesis in cyanobacteria

Neilan, Brett A.; Pearson, Leanne A.; Muenchhoff, Julia; Moffitt, Michelle C.; Dittmann, Elke

doi:10.1111/j.1462-2920.2012.02729.x

Cited by 296 publications

(219 citation statements)

References 94 publications

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“…In addition, the natural or induced dispersion of cyanobacterial blooms poses a secondary detriment to the quality of water resources through the release of toxic secondary metabolites, collectively termed cyanotoxins (Carmichael, 2001;Ibelings and Chorus, 2007;Funari and Testai, 2008). The extent to which certain cyanobacterial species exhibit dominance over other phytoplankton, during bloom events or otherwise, has been shown to be dictated by differences in the physiological response of these organisms to prevailing abiotic factors (Paerl, 1996;Davis et al, 2009;Rouco et al, 2011;Neilan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…There is an evident difficulty in correlating many environmental parameters with cyanobacterial community composition, toxicity or toxigenicity across such studies (Rinta-Kanto et al, 2009;Al-Tebrineh et al, 2011;Otten et al, 2012;Lee et al, 2014;Ngwa et al, 2014). In part, this lack of correlation can be attributed to genomic variability among closely related strains (Humbert et al, 2013;Sinha et al, 2014), giving rise to differing growth optima and potential to produce a myriad of toxic and non-toxic metabolites (Humbert et al, 2013), changes in the genome copy number throughout the growth phase (Griese et al, 2011) and uncertainty regarding the control of regulatory systems that direct the expression of toxic metabolites (Kaebernick et al, 2000;Alexova et al, 2011;Carneiro et al, 2013;Neilan et al, 2013;Rzymski and Poniedziałek, 2014;Makower et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake

et al. 2015

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The frequency of freshwater cyanobacterial blooms is at risk of increasing as a consequence of climate change and eutrophication of waterways. It is increasingly apparent that abiotic data are insufficient to explain variability within the cyanobacterial community, with biotic factors such as heterotrophic bacterioplankton, viruses and protists emerging as critical drivers. During the Australian summer of 2012-2013, a bloom that occurred in a shallow ephemeral lake over a 6-month period was comprised of 22 distinct cyanobacteria, including Microcystis, Dolichospermum, Oscillatoria and Sphaerospermopsis. Cyanobacterial cell densities, bacterial community composition and abiotic parameters were assessed over this period. Alpha-diversity indices and multivariate analysis were successful at differentiating three distinct bloom phases and the contribution of abiotic parameters to each. Network analysis, assessing correlations between biotic and abiotic variables, reproduced these phases and assessed the relative importance of both abiotic and biotic factors. Variables possessing elevated betweeness centrality included temperature, sodium and operational taxonomic units belonging to the phyla Verrucomicrobia, Planctomyces, Bacteroidetes and Actinobacteria. Species-specific associations between cyanobacteria and bacterioplankton, including the free-living Actinobacteria acI, Bacteroidetes, Betaproteobacteria and Verrucomicrobia, were also identified. We concluded that changes in the abundance and nature of freshwater cyanobacteria are associated with changes in the diversity and composition of lake bacterioplankton. Given this, an increase in the frequency of cyanobacteria blooms has the potential to alter nutrient cycling and contribute to long-term functional perturbation of freshwater systems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake

et al. 2015

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“…Numerous studies based on field samples and laboratory cultures have addressed the question how changes in environmental conditions have an impact on MC production (Neilan et al 2012), including nutrient elements (Song et al 1998;Jiang et al 2008;Wu et al 2006), temperature (Sivonen 1996), pH (Song et al 1998) and light intensity (Sivonen 1990). Nitrogen, phosphorous and the ratio of nitrogen and phosphorus were regarded as the important factors for Microcystis blooms and MC production (Chorus et al 2001;Gupta et al 2001;Gobler et al 2007;Jiang et al 2008;Joo et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Variation of Microcystis and microcystins coupling nitrogen and phosphorus nutrients in Lake Erhai, a drinking-water source in Southwest Plateau, China

Jiang

Song

et al. 2014

Environ Sci Pollut Res

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Lake Erhai is the second largest lake of Southwest China and an important drinking water source. The lake is currently defined as the preliminary stage of eutrophic states, but facing a serious threat with transfer into intensive eutrophication. The present study examined the dynamics of Microcystis blooms and toxic Microcystis in Lake Erhai during 2010, based on quantitative real-time PCR method using 16S rRNA gene specific for Microcystis and microcystin systhesis gene (mcy), and chemical analysis on microcystin (MC) concentrations. Total Microcystis cell abundance at 16 sampling sites were shown as an average of 1.7×10 7 cells l −1 (1.3×10 2 -3.8×10 9 cells l −1 ). Microcystin LR (MC-LR) and microcystin RR (MC-RR) were the main variants. The strong southwesterly winds, anticlockwise circular flows and geographical characteristics of lake and phytoplankton community succession impacted the distribution patterns of Chl a and MC in the lake. The concentration of Chl a and MC and abundances of total Microsytis and MC-producing Microsystis (MCM) were shown to be positively correlated with pH, DO and TP, negatively correlated with SD, NO 3 -N, TN/Chl a and TN/TP, and not correlated with NH 4 -N, TN, dissolved total nitrogen (DTN) and water temperatures. When TN/TP decrease, Microcystis tended to dominate and MC concentrations tended to increase, suggesting that the "TN/TP rule" can be partially applied to explain the correlation between the cyanobacterial blooms and nutrients N and P only within a certain nutrient level. It is speculated that N and P nutrients and the associated genes (e.g., mcy) may jointly drive MC concentration and toxigenicity of Microcystis in Lake Erhai.

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“…Many environmental factors, including temperature, pH, light, ultraviolet light, nutrients (mainly are nitrogen and phosphorus), and metal ions, have been reported to affect cyanobacteria growth and toxin production (Rapala et al 1997;Kotak et al 2000;Downing et al 2005;Jiang et al 2008;Sevilla et al 2008;Davis et al 2009;Neilan et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Effects of linear alkylbenzene sulfonate on the growth and toxin production of Microcystis aeruginosa isolated from Lake Dianchi

Wang

Zhang

Song

et al. 2014

Environ Sci Pollut Res

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The exogenous organic pollutant linear alkylbenzene sulfonate (LAS) pollution and Microcystis bloom are two common phenomena in eutrophic lakes, but the effects of LAS alone on Microcystis remain unclear. In the present study, we investigated the effects of LAS on the growth, photochemical efficiency, and microcystin production of Microcystis aeruginosa in the laboratory. Results showed that low LAS (≤10 mg/L) concentrations improved the growth of M. aeruginosa (12 days of exposure). High LAS (20 mg/L) concentrations inhibited the growth of M. aeruginosa on the first 8 days of exposure; afterward, growth progressed. After 12 days of exposure, the concentrations of chlorophyll a in algal cells were not significantly affected by any of LAS concentrations (0.05 to 20 mg/L) in the present study; by contrast, carotenoid and protein concentrations were significantly inhibited when LAS concentrations reached as high as 20 mg/L. After 6 and 12 days of exposure, low LAS (≤10 mg/ L) concentrations enhanced the maximal photochemical efficiency (Fv/Fm) and the maximal electron transport rate (ETRmax) of M. aeruginosa. Furthermore, LAS increased the microcystin production of M. aeruginosa. Extracellular and intracellular microcystin contents were significantly increased after M. aeruginosa was exposed to high LAS concentrations. Our results indicated that LAS in eutrophic lakes may increase the risk of Microcystis bloom and microcystin production.

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Environmental conditions that influence toxin biosynthesis in cyanobacteria

Cited by 296 publications

References 94 publications

Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake

Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake

Variation of Microcystis and microcystins coupling nitrogen and phosphorus nutrients in Lake Erhai, a drinking-water source in Southwest Plateau, China

Effects of linear alkylbenzene sulfonate on the growth and toxin production of Microcystis aeruginosa isolated from Lake Dianchi

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