Environmental degradation of the insect growth regulator methoprene (isopropyl(2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate).  II.  Metabolism by aquatic microorganisms

Da, Schooley; Bj, Bergot; Ll, Dunham; Jb, Siddall

doi:10.1021/jf60198a059

Cited by 49 publications

(33 citation statements)

References 5 publications

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“…albopictus were more often collected in the shade it was at a rate that matched container occurrence and therefore did not indicate preference. An alternative explanation for our findings is that the negative effect of UV light on the persistence of insecticides [50,51] results in higher survivorship in containers exposed to the sun, which would shift the occurrence of immature Ae. albopictus to sunny sites and mask female preference for containers in the shade.…”

Section: Discussionmentioning

confidence: 90%

Crouching Tiger, Hidden Trouble: Urban Sources of Aedes albopictus (Diptera: Culicidae) Refractory to Source-Reduction

et al. 2013

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Our ultimate objective is to design cost-effective control strategies for Aedes albopictus, the Asian tiger mosquito, an important urban nuisance and disease vector that expanded worldwide during the last 40 years. We conducted mosquito larval surveys from May through October 2009 in the City of Trenton, New Jersey, USA, while performing intensive monthly source-reduction campaigns that involved removing, emptying, or treating all accessible containers with larvicides and pupicides. We examined patterns of occurrence of Ae. albopictus and Culex pipiens, another urban mosquito, among different container types by comparing observed and expected number of positive containers of each type. Expected use was based on the relative frequency of each container type in the environment. Aedes albopictus larvae and pupae were found significantly more often than expected in medium volumes of water in buckets and plant saucers but were rarely collected in small volumes of water found in trash items such as discarded cups and cans. They were also absent from large volumes of water such as in abandoned swimming pools and catch basins, although we consistently collected Cx. pipiens from those habitats. The frequency of Ae. albopictus in tires indicated rapid and extensive use of these ubiquitous urban containers. Standard larval-based indices did not correlate with adult catches in BG-Sentinel traps, but when based only on Ae. albopictus key containers (buckets, plant saucers, equipment with pockets of water, and tires) they did. Although we found that only 1.2% of the 20,039 water-holding containers examined contained immature Ae. albopictus (5.3% if only key containers were counted), adult populations were still above nuisance action thresholds six times during the 2009 mosquito season. We conclude that in urban New Jersey, effective source reduction for Ae. albopictus control will require scrupulous and repeated cleaning or treatment of everyday use containers and extensive homeowner collaboration.

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Section: Discussionmentioning

confidence: 90%

Crouching Tiger, Hidden Trouble: Urban Sources of Aedes albopictus (Diptera: Culicidae) Refractory to Source-Reduction

et al. 2013

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“…Formulation technology may also help photosensitive compounds overcome environmental degradation. For example, methoprene has a half-life of 30–40 h depending on the initial concentration (Schooley et al 1975). Slow release formulations combined with UV-blocking additives allow some formulations of methoprene to remain biologically active in the environment for months.…”

Section: Resultsmentioning

confidence: 99%

The Biological Activity of α-Mangostin, a Larvicidal Botanic Mosquito Sterol Carrier Protein-2 Inhibitor

Larson¹,

Lorch²,

Pridgeon³

et al. 2010

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alpha-Mangostin derived from mangosteen was identified as a mosquito sterol carrier protein-2 inhibitor via high throughput insecticide screening, alpha-Mangostin was tested for its larvicidal activity against third instar larvae of six mosquito species, and the median lethal concentration values range from 0.84 to 2.90 ppm. The residual larvicidal activity of alpha-mangostin was examined under semifield conditions. The results indicated that alpha-mangostin was photolytic with a half-life of 53 min in water under full sunlight exposure. The effect of alpha-mangostin on activities of major detoxification enzymes such as P450, glutathione S-transferase, and esterase was investigated. The results showed that alpha-mangostin significantly elevated activities of P450 and glutathione S-transferase in larvae, whereas it suppressed esterase activity. Toxicity of alpha-mangostin against young rats was studied, and there was no detectable adverse effect at dosages as high as 80 mg/kg. This is the first multifaceted study of the biological activity of alpha-mangostin in mosquitoes. The results suggest that alpha-mangostin may be a lead compound for the development of a new organically based mosquito larvicide.

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“…23, 2004 1309 different cell types [22]. Microbial degradation is dependent on the constitution of the microbial population, as demonstrated by studies in which water samples from different natural sources yielded vastly different compositions of breakdown products [15,16]. Methoprene has been applied as a mosquito control agent in metropolitan and suburban areas, to control flies in dairy operations, and as an active ingredient in domestic flea sprays [15].…”

Section: Discussionmentioning

confidence: 99%

“…Methoprene (isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate), an analog of JHIII, is widely applied to wetlands in urban and suburban areas to reduce mosquito populations, as a feed additive for dairy cows to control flies, and in flea collars and sprays [15]. However, methoxy-methoprene acid (methoprene acid), a relatively stable metabolite [16], has been shown to activate transcription of vertebrate RXR-stimulated reporter genes in transfected insect cells [17]. However, methoxy-methoprene acid (methoprene acid), a relatively stable metabolite [16], has been shown to activate transcription of vertebrate RXR-stimulated reporter genes in transfected insect cells [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of methoprene, its metabolites, and breakdown products on retinoid‐activated pathways in transfected cell lines

Schoff

Ankley

2004

Enviro Toxic and Chemistry

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Methoprene (isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate) is an insect juvenile hormone agonist that blocks metamorphosis in some insects. Recent evidence suggests that a metabolite, methoprene acid, activates vertebrate retinoid X receptors (RXRs), and may interfere with retinoic acid-regulated developmental processes. Methoprene, methoxy-methoprene acid, and two major breakdown products were tested for their ability to interfere with retinoid-regulated pathways when using transfected cells. The CV-1 cells were transiently transfected with genes encoding RXRs and response elements attached to luciferase reporters, and retinoic acid-sensitive F9 cells were stably transfected with retinoic acid receptor (RAR)/RXR response elements attached a lacZ reporter (Sil-REM/beta-gal-NEO). Experiments confirmed that methoxy-methoprene acid acted as a ligand for RXRs and was capable of activating transcription through RAR/RXR response elements. However, neither methoprene nor the breakdown products, 7-methoxycitronellal and 7-methoxycitronellic acid, activated transcription in transfected CV-1 or F9 cells. Methoprene and methoxy-methoprene acid may interfere with the conversion of all-trans-retinol and all-trans-retinaldehyde to all-trans-retinoic acid in the F9-derived cell line. Methoprene was as effective as the retinol dehydrogenase inhibitor citral in blocking the retinol-induced transcription of RAR/RXR-regulated reporter genes, whereas methoxy-methoprene acid blocked transcription stimulated by retinaldehyde.

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Environmental degradation of the insect growth regulator methoprene (isopropyl(2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate). II. Metabolism by aquatic microorganisms

Cited by 49 publications

References 5 publications

Crouching Tiger, Hidden Trouble: Urban Sources of Aedes albopictus (Diptera: Culicidae) Refractory to Source-Reduction

Crouching Tiger, Hidden Trouble: Urban Sources of Aedes albopictus (Diptera: Culicidae) Refractory to Source-Reduction

The Biological Activity of α-Mangostin, a Larvicidal Botanic Mosquito Sterol Carrier Protein-2 Inhibitor

Effects of methoprene, its metabolites, and breakdown products on retinoid‐activated pathways in transfected cell lines

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