Leadership in Energy and Environmental Design (LEED) has five basic categories: Sustainable sites (SS), Water Efficiency (WE), Energy and Atmosphere (EA), Materials and Resources (MR), and Indoor Environmental Quality (EQ). Additionally, in LEED 2009, the U.S. Green Building Council (USGBC) introduced regional priority (RP) points to adapt LEED to the local conditions of foreign countries. However, the appropriateness of the RP points stated for the Mediterranean basin has not yet been evaluated. Thus, we studied the similarities and differences in performances of LEED 2009 Commercial Interiors (CI) and LEED 2009 Core and Shell Development (C&S) Gold certified projects in Turkey, Spain, and Italy. We revealed that the categories without RP points, SS, MR, and EQ, performed similarly in all three countries, thereby signaling the correctness of CI and C&S applications in the Mediterranean basin. However, the categories with RP points, WE and EA, performed differently. It can be suggested that the following RP points would be beneficial for all three countries: (i) in the MR category, RP points that initiate decreases in virgin construction material; (ii) in the WE category, RP points that encourage water saving; and (iii) in the EA category, RP points that encourage using renewable energies.