Environmental Enrichment Preserves Cortical Inputs to the Parahippocampal Areas and Reduces Post Stroke Diaschisis

Wang, Yonggang; Bontempi, Bruno; Leinekugel, Xavier; Lesburguères, Edith; Liu, Wei; Weinstein, Philip; Zhao, Jizong; Abrams, Gary; Liu, Jialing

doi:10.1166/ajnn.2011.1027

Cited by 8 publications

(20 citation statements)

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“…Under urethane anesthesia, dMCAO produced an ischemic lesion mainly in the somatosensory cortex (Figure 2(f)), a location similar to that seen under isoflurane anesthesia. 8,44 Infarct volume determined at 1–1.5 h after reperfusion was 24.85 ± 7.50 mm 3 , significantly smaller than the lesion size observed at five to seven weeks after dMCAO in our previous studies. 44…”

Section: Resultscontrasting

confidence: 64%

“…Stroke was induced unilaterally in rats by the distal middle cerebral artery occlusion (dMCAO) method in combination with supplemental proximal artery occlusion of the bilateral common carotid arteries (CCAO) under isoflurane (1.5%)/O 2 (30%)/N 2 O(68.5%) anesthesia as described previously, 44 producing cortical infarct restricted to the somatosensory (SS) cortex in the absence of direct hippocampal injury. 8 In brief, a 1.5 mm diameter burr hole 1 mm rostral to the anterior junction of the zygoma and temporalis bone was made with a dental drill. The dura mater was carefully pierced with a 30-gauge needle.…”

Section: Methodsmentioning

confidence: 99%

“…as described. 8,45 Following craniotomy, two electrodes (A1x32-6mm-50-177 into the ipsilateral side and A1x16-5mm-100-703 into the contralateral side, respectively) were slowly inserted into the brain after the dura mater was resected to target the dorsal hippocampus at (AP: À3.3 mm; ML: AE 2 mm) via a stereotaxic frame (David Kopf Instruments, Tujunga, CA, USA). The electrode and recording sites in the brain are shown in Figure 1(a) to (c).…”

Section: Recordingmentioning

confidence: 99%

“…[4][5][6] Consistent with clinical observation, cognitive impairment can be detected in animal models of stroke in the absence of hippocampal injury. 7,8 However, the neural changes in the hippocampus that may underlie the functional impairment induced by cortical stroke are not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication

Rabiller

Nishijima

et al. 2019

J Cereb Blood Flow Metab

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The functional consequences of ischemic stroke in the remote brain regions are not well characterized. The current study sought to determine changes in hippocampal oscillatory activity that may underlie the cognitive impairment observed following distal middle cerebral artery occlusion (dMCAO) without causing hippocampal structural damage. Local field potentials were recorded from the dorsal hippocampus and cortex in urethane-anesthetized rats with multichannel silicon probes during dMCAO and reperfusion, or mild ischemia induced by bilateral common carotid artery occlusion (CCAO). Bilateral change of brain state was evidenced by reduced theta/delta amplitude ratio and shortened high theta duration following acute dMCAO but not CCAO. An aberrant increase in the occurrence of sharp-wave-associated ripples (150–250 Hz), crucial for memory consolidation, was only detected after dMCAO reperfusion, coinciding with an increased occurrence of high-frequency discharges (250–450 Hz). dMCAO also significantly affected the modulation of gamma amplitude in the cortex coupled to hippocampal theta phase, although both hippocampal theta and gamma power were temporarily decreased during dMCAO. Our results suggest that MCAO may disrupt the balance between excitatory and inhibitory circuits in the hippocampus and alter the function of cortico-hippocampal network, providing a novel insight in how cortical stroke affects function in remote brain regions.

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Section: Resultscontrasting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Section: Recordingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication

Rabiller

Nishijima

et al. 2019

J Cereb Blood Flow Metab

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“…The hippocampus is involved in memory function, but direct ischemic lesions strategic to the hippocampus or parahippocampal regions are rarely observed in middle cerebral artery (MCA) stroke 1 2 3 . Previously, we found that stroke by distal occlusion of MCA (dMCAO) produced injury restricted to the cortex and mild memory impairment 4 . A number of cortical areas affected by dMCAO including the parietal cortex are strongly interconnected by other cortical, subcortical, diencephalic, mesencephalic and brainstem regions of the ipsilateral side of the occlusion as well as the contralateral hemisphere.…”

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confidence: 99%

Prediction of regional functional impairment following experimental stroke via connectome analysis

Schmitt

Badurek

Liu

et al. 2017

Sci Rep

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Recent advances in functional connectivity suggest that shared neuronal activation patterns define brain networks linking anatomically separate brain regions. We sought to investigate how cortical stroke disrupts multiple brain regions in processing spatial information. We conducted a connectome investigation at the mesoscale-level using the neuroVIISAS-framework, enabling the analysis of directed and weighted connectivity in bilateral hemispheres of cortical and subcortical brain regions. We found that spatial-exploration induced brain activation mapped by Fos, a proxy of neuronal activity, was differentially affected by stroke in a region-specific manner. The extent of hypoactivation following spatial exploration is inversely correlated with the spatial distance between the region of interest and region damaged by stroke, in particular within the parietal association and the primary somatosensory cortex, suggesting that the closer a region is to a stroke lesion, the more it would be affected during functional activation. Connectome modelling with 43 network parameters failed to reliably predict regions of hypoactivation in stroke rats exploring a novel environment, despite a modest correlation found for the centrality and hubness parameters in the home-caged animals. Further investigation in the inhibitory versus excitatory neuronal networks and microcircuit connectivity is warranted to improve the accuracy of predictability in post-stroke functional impairment.

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Local field potentials identify features of cortico-hippocampal communication impacted by stroke and environmental enrichment therapy

Ip¹,

Rabiller²,

He³

et al. 2021

J. Neural Eng.

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Objective. Cognitive and memory impairments are common sequelae after stroke, yet how middle cerebral artery (MCA) stroke chronically affects the neural activity of the hippocampus, a brain region critical for memory but remote from the stroke epicenter, is poorly understood. Environmental enrichment (EE) improves cognition following stroke; however, the electrophysiology that underlies this behavioral intervention is still elusive. Approach. We recorded extracellular local field potentials simultaneously from sensorimotor cortex and hippocampus in rats during urethane anesthesia following MCA occlusion and subsequent EE treatment. Main results. We found that MCA stroke significantly impacted the electrophysiology in the hippocampus, in particular it disrupted characteristics of sharp-wave associated ripples (SPW-Rs) altered brain state, and disrupted phase amplitude coupling (PAC) within the hippocampus and between the cortex and hippocampus. Importantly, we show that EE mitigates stroke-induced changes to SPW-R characteristics but does not restore hippocampal brain state or PAC. Significance. These results begin to uncover the complex interaction between cognitive deficit following stroke and EE treatment, providing a testbed to assess different strategies for therapeutics following stroke.

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Environmental Enrichment Preserves Cortical Inputs to the Parahippocampal Areas and Reduces Post Stroke Diaschisis

Cited by 8 publications

References 0 publications

Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication

Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication

Prediction of regional functional impairment following experimental stroke via connectome analysis

Local field potentials identify features of cortico-hippocampal communication impacted by stroke and environmental enrichment therapy

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