Environmental Exposure Science and Human Health

Lavezzi, Anna Maria; Ramos‐Molina, Bruno

doi:10.3390/ijerph20105764

Cited by 6 publications

(4 citation statements)

References 44 publications

(43 reference statements)

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“…Exploring electrophiles as regulators of metabolic pathways (e.g., glucose metabolism and lipid homeostasis) could yield novel therapeutic strategies for conditions like diabetes and obesity [ 299 ]; Environmental exposure. Investigating the impact of ECs from environmental sources (e.g., air pollution and dietary components) on human health is an emerging field [ 300 ]. …”

Section: Role Of Electrophilic Compounds In Diseasesmentioning

confidence: 99%

“…Environmental exposure. Investigating the impact of ECs from environmental sources (e.g., air pollution and dietary components) on human health is an emerging field [ 300 ].…”

Section: Role Of Electrophilic Compounds In Diseasesmentioning

confidence: 99%

“…By designing molecules that interact with specific cellular components, we can create more effective and safer drugs [287]; Environmental exposure. Investigating the impact of ECs from environmental sources (e.g., air pollution and dietary components) on human health is an emerging field [300].…”

mentioning

confidence: 99%

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Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

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The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.

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Section: Role Of Electrophilic Compounds In Diseasesmentioning

confidence: 99%

“…Environmental exposure. Investigating the impact of ECs from environmental sources (e.g., air pollution and dietary components) on human health is an emerging field [ 300 ].…”

Section: Role Of Electrophilic Compounds In Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

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“…The environment's state significantly impacts human health (Lavezzi & Ramos-Molina, 2023;Shetty et al, 2023). The degradation of environmental quality has a significant influence on one's quality of life.…”

Section: Introductionmentioning

confidence: 99%

Navigating Smog: Legislation Addressing Children’s Right to Health in India and Pakistan

Ali

2023

Hum. Rights Glob. South.

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The negative consequences of air pollution on children’s health have reached a crisis in some South Asian countries, such as India and Pakistan, particularly in the sister cities of Delhi and Lahore. Urban air pollution poses unique dangers to the health of children. Children are particularly susceptible to the health impacts of smog since their organs and immune systems are still developing. Smog has been related to a variety of chronic health issues, including retarded lung development and cognitive impairment. The Convention on the Rights of the Child (CRC) emphasises that all children have the right to grow up in a secure and healthy setting. Governments are obligated to provide children with health care and a safe environment under the CRC. The health of children in heavily populated and industrialised cities like Delhi and Lahore needs legal safeguards. A nuanced picture emerges of the effectiveness of laws protecting children's health during smog in Delhi and Lahore. In Delhi and Lahore, there is a dire need for comprehensive laws to safeguard children's health during smog. Comprehensive legislation is essential to mandate pollution control measures, improve air quality, and ensure a healthier future for the region's children. There are several issues caused by smog, and this article advocates for reforms to the laws in Delhi and Lahore that aim to solve these issues.

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Deciphering the environmental chemical basis of muscle quality decline by interpretable machine learning models

Feng,

Chen,

Guo

et al. 2024

The American Journal of Clinical Nutrition

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Environmental Exposure Science and Human Health

Abstract: Human health and environmental exposure form an inseparable binomial [...]

Cited by 6 publications

References 44 publications

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Navigating Smog: Legislation Addressing Children’s Right to Health in India and Pakistan

Deciphering the environmental chemical basis of muscle quality decline by interpretable machine learning models

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