Environmental exposure to swine farms reshapes human gut microbiota

Shang, Peng; Dong, Shixiong; Han, Yaling; Bo, Suxue; Ye, Yourong; Duan, Mengqi; Chamba, Yangzom

doi:10.1016/j.chemosphere.2022.135558

Cited by 7 publications

(4 citation statements)

References 58 publications

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“…It has been well established that composition determines the functions of microbial communities ( Wang et al, 2022 ). Prior research indicated that occupational exposure might reshape the functions of gut microbiota regarding nutrient catabolism, stress response, and bacterial pathogenesis ( Shang et al, 2022 ; Xie et al, 2022 ). However, even though it is of high interest, little is known about how skin and nasal bacteria functionally respond to occupational exposure.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure in swine farm defines human skin and nasal microbiota

Wang

Chen

et al. 2023

Front. Microbiol.

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Anthropogenic environments take an active part in shaping the human microbiome. Herein, we studied skin and nasal microbiota dynamics in response to the exposure in confined and controlled swine farms to decipher the impact of occupational exposure on microbiome formation. The microbiota of volunteers was longitudinally profiled in a 9-months survey, in which the volunteers underwent occupational exposure during 3-month internships in swine farms. By high-throughput sequencing, we showed that occupational exposure compositionally and functionally reshaped the volunteers’ skin and nasal microbiota. The exposure in farm A reduced the microbial diversity of skin and nasal microbiota, whereas the microbiota of skin and nose increased after exposure in farm B. The exposure in different farms resulted in compositionally different microbial patterns, as the abundance of Actinobacteria sharply increased at expense of Firmicutes after exposure in farm A, yet Proteobacteria became the most predominant in the volunteers in farm B. The remodeled microbiota composition due to exposure in farm A appeared to stall and persist, whereas the microbiota of volunteers in farm B showed better resilience to revert to the pre-exposure state within 9 months after the exposure. Several metabolic pathways, for example, the styrene, aminobenzoate, and N-glycan biosynthesis, were significantly altered through our PICRUSt analysis, and notably, the function of beta-lactam resistance was predicted to enrich after exposure in farm A yet decrease in farm B. We proposed that the differently modified microbiota patterns might be coordinated by microbial and non-microbial factors in different swine farms, which were always environment-specific. This study highlights the active role of occupational exposure in defining the skin and nasal microbiota and sheds light on the dynamics of microbial patterns in response to environmental conversion.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure in swine farm defines human skin and nasal microbiota

Wang

Chen

et al. 2023

Front. Microbiol.

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“…For example, the water in the greenhouse may be more restricted and controlled and the water quality more stable, while the water in the pond will be vulnerable to the influence of the surrounding environment, such as weather changes, plants, sediment, etc. [ 50 , 51 ]. These environmental differences may affect the microbial diversity and abundance in each water body, which will in turn affect the digestive tracts of the SSTs.…”

Section: Discussionmentioning

confidence: 99%

Variations in the Intestinal Microbiota of the Chinese Soft-Shelled Turtle (Trionyx sinensis) between Greenhouse and Pond Aquaculture

Liu,

Zhang,

Xue

et al. 2023

Animals

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The microbial community structure in aquaculture water plays an important role in the intestinal microbial diversity of aquatic animals. The Chinese soft-shelled turtle (SST) (Trionyx sinensis) is an important aquaculture species of high economic value in the Asia-Pacific region. An intuitive understanding of the microbial diversity and abundances of SST aquaculture is crucial for comprehending these ecosystems. Herein, the evolutionary characteristics of the bacterial communities in the SST and its aquaculture water systems were investigated using Illumina MiSeq sequencing. This experiment sampled nine SSTs from a pond outside a greenhouse and was repeated three times. The sequencing results revealed significant differences in the microflora composition at the phylum and genus levels in both the intestine and aquaculture water of the SSTs in the greenhouse and pond aquaculture environments. A total of 1039 genera belonging to 65 phyla were identified. At the phylum level, the relative abundances of Chloroflexi (24%), Acidobacteria (5%), and Nitrospira (3%) were higher in the greenhouse water than in the pond water. The relative abundances of Bacteroidetes (35%), Actinobacteria (8%), and Cyanobacteria (4%) were higher in the pond water than in the greenhouse water. The intestinal microorganisms in the SSTs experienced significant changes after the SSTs were transferred from a greenhouse culture to a pond culture environment for 28 days. After the SSTs were cultured in the ponds, we observed decreases in the relative abundances of Actinobacteria (39% to 25%), Cyanobacteria (24% to 0.8%), Chlorobacteria (9% to 3%), and Firmicutes (5.5% to 0.8%. However, we observed increases in the relative abundances of Bacteroidetes (2% to 35%) and Acidobacteria (0.3% to 25%). These results showed that the bacterial diversity and richness compositions in the intestinal tract and aquaculture water were the same. However, the relative abundances of bacterial communities varied. The results of this study are of great significance in understanding how the environment affects SST cultures. These data may provide valuable instructions for Chinese soft-shelled turtle aquaculture management.

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“…It is possible that the process of aerosolization, where pig faeces microbes from the upper respiratory tract enter the gastrointestinal tract, could result in changes to the population of faeces microbes (Moor et al 2021). Many factors, including dietary habits and the environment, have an impact on the composition of the gut microbes, which in turn influences physical health in a variety of ways (Shang et al 2022;Martel et al 2022;Yang et al 2022). Therefore, it is crucial to investigate the effects of occupational exposure on the intestinal microbes of farmers.…”

Section: Introductionmentioning

confidence: 99%

Effects of microbes in pig farms on occupational exposed persons and the environment

Han,

Li,

et al. 2023

AMB Expr

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In terms of pig farming, pig gut microbes have a significant effect on farmers and the farm environment. However, it is still unclear which microbial composition is more likely to contribute to this effect. This study collected a total of 136 samples, including pigs’ faeces samples, farmers’ faeces samples, samples from individuals who had no contact with any type of farm animal (referred to as ‘non-exposed’ persons), and environmental dust samples (collected from inside and outside pig houses and the farm) from two pig farms, pig farm A and pig farm B. Whereafter, 16S rRNA sequencing and taxonomic composition analysis were performed. According to the study, compared to non-exposed persons, pig farmers had a significantly higher abundance of 7 genera. In addition, the farmers were grouped according to the duration of their occupational exposure, and it was shown that 4 genera, including Turicibacter, Terrisporobacter, and Clostridium_sensu_stricto_1, exhibited a rise in more frequent contact with pigs. As compared to outside the pig house, the environmental dust has a greater concentration of the 3 bacteria mentioned before. Therefore, these 3 microbes can be considered as co-occurring microbes that may exist both in humans and the environment. Also, the 3 co-occurring microbes are involved in the fermentation and production of short-chain fatty acids and their effectiveness decreased as distance from the farm increased. This study shows that the 3 microbes where pig farmers co-occur with the environment come from pig farms, which provides fresh ideas for preventing the spread of microbial aerosols in pig farms and reducing pollution.

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Environmental exposure to swine farms reshapes human gut microbiota

Cited by 7 publications

References 58 publications

Occupational exposure in swine farm defines human skin and nasal microbiota

Occupational exposure in swine farm defines human skin and nasal microbiota

Variations in the Intestinal Microbiota of the Chinese Soft-Shelled Turtle (Trionyx sinensis) between Greenhouse and Pond Aquaculture

Effects of microbes in pig farms on occupational exposed persons and the environment

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