Variations and change orders are inevitable in the course of implementing a construction investment project. It can appear throughout the project from the design phase to the construction, acceptance, and completion of the project. This change affects more or less the schedule, quality, and cost of the project. On the other hand, variations and changes orders may also cause disputes and conflicts among project stakeholders. In order to overcome this issue, this paper presents critical the factors which need to be addressed and used for change orders in design-build projects in Vietnam. The results showed that written instructions, variation value, and scope of variation are the three most important factors used in the variation management process in design-build projects in Vietnam.