Environmental factors affecting pregnancy outcomes

Sakali, Anastasia-Konstantina; Papagianni, Maria; Bargiota, Αlexandra; Rašić-Marković, Aleksandra; Macut, Djuro; Mastorakos, George

doi:10.1007/s12020-023-03307-9

Cited by 6 publications

(5 citation statements)

References 86 publications

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“…These results were in accord with many previous studies 3 , 8 , 26 – 28 . These chemicals are EDs that might disrupt normal body homeostasis resulting in major health problems such as malignant transformation, abnormal reproduction, fetal maldevelopment, and diabetes mellitus 26 , 28 .…”

Section: Discussionsupporting

confidence: 94%

“…These chemicals are EDs that might disrupt normal body homeostasis resulting in major health problems such as malignant transformation, abnormal reproduction, fetal maldevelopment, and diabetes mellitus 26 , 28 . Intrauterine exposure to these EDs especially during the early developmental phases has several negative impacts including the increasing rates of RPL 2 , 3 , 8 . Most of the OCPs’ bad effects come from the disruption of the signaling cascades for many hormones such as thyroid, HCG, and sex steroids 6 , 7 , 10 , 24 , 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

El-Baz

Amin

Mohany

2023

Sci Rep

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We investigated the plasma levels of pesticides components namely polychlorinated biphenyls (PCBs), dieldrin, dichlorodiphenyldichloroethylene (DDE), ethion, malathion, and chlorpyrifos in recurrent pregnancy loss (RPL) cases, and tested their associations with placental oxidative stress (OS) biomarkers [nitric oxide (NO.), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), and superoxide dismutase (SOD)] and with placental apoptotic/antiapoptotic indices (Bcl-2 and caspase-3), and evaluated their possible cut-off points to distinguish RPL cases. The study recruited 101 pregnant women divided into; G1 [n = 49, control, normal 1st-trimester pregnancy, normal obstetric history with at least one previous normal live birth], G2 [n = 26, cases with missed abortion (< 3 abortions) before 24 weeks of gestation], and G3 [n = 26, cases with missed abortion (≥ 3 abortions) before 24 weeks of gestation]. The plasma pesticide levels were analyzed by gas chromatography-mass spectrometry. Plasma human chorionic gonadotrophin (HCG), placental OS, Bcl-2, and caspase-3, were analyzed by their corresponding methods and kits. Plasma PCBs, DDE, dieldrin, and ethion levels were significantly higher in RPL cases than in normal pregnancies (p ≤ 0.001). These levels correlated positively with placental OS and apoptosis and negatively with plasma HCG levels. Also, these levels were reliable markers of risk to RPL. Malathion and chlorpyrifos were not detected in any of the study’s participants. Pesticides may be risk factors in cases of spontaneous RPL cases. They are associated with an increasing placental OS and placental apoptosis. Specific measures should be taken to decrease maternal exposure to these pollutants’ sources, especially in underdeveloped and developing countries.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

El-Baz

Amin

Mohany

2023

Sci Rep

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“…S tim u vezi, pokazano je da unos hrane bogate pesticidima (pre ili postnatalno) može dovesti do poremećaja puberteta (utiču na vreme nastanka, progresiju i završetak puberteta), s obzirom da se ponašaju kao supstance koje mogu menjati funkcije endokrinog sistema (endocrine disrupting chemicals -EDCs) [19]. Studije su pokazale pozitivnu vezu između izlaganja EDCs i komplikacija trudnoće (vanmaterične trudnoće, gubici trudnoće, gestacioni dijabetes melitus, hipertenzija u trudnoći, prevremeni porođaj), kao i rađanja dece sa IUGR, dece male ili velike težine za gestacijsku starost [20]. Važno je spomenuti i prediktore prisutne kod majke.…”

Section: The Impact Of Nutritionunclassified

“…With respect to this, it has been shown that the intake of food rich in pesticides (prenatally or postnatally) can lead to puberty disorders (pesticides affect the onset, progression, and completion of puberty), considering that they act as substances than can alter the functions of the endocrine system (endocrine disrupting chemicals -EDCs) [19]. Studies have shown a positive correlation between EDC exposures and pregnancy complications (ectopic pregnancies, miscarriages, gestational diabetes mellitus, hypertension in pregnancy, premature birth), as well as children born with IUGR, small for gestational age or large for gestational age [20]. It is also important to mention maternal predictors.…”

Section: Sklonost Ka Metaboličkim Poremećajimamentioning

confidence: 99%

Maternofetal interaction and modulation in creating a new population: A review of current evidence on the relationship between fetal nutrition and the development of chronic diseases later in life

Novaković,

Todorović,

Dugalić

et al. 2023

Srpski medicinski časopis Lekarske komore

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The concept of fetal programming has found its place in science and keeps lighting the way to better understanding of fetal life and its impact on postnatal and adult life. Its capacity is much wider than a common recognition of the fact that different disorders in pregnancy impact fetal health, and these capacities keep being confirmed by various observational studies and experimental models. Another fact that makes fetal programming even harder to confirm and accept is the long period between the stimulus and its consequences, as well as various factors that can change and influence this period of one's lifetime. Nevertheless, different hypotheses are present, concerning suboptimal fetal health and nutrition and their contribution to the development of chronic diseases during one's lifetime - inadequate nutrition during intrauterine period and early childhood can permanently change one's physiology and metabolism, which contributes to a possible development of chronic diseases (hypertension, coronary artery disease, stroke, diabetes, etc.). The aim of this paper is to review current evidence on the relationship between fetal nutrition and the risk of chronic diseases later in life. A detailed review of current literature and the analysis of various studies aimed at following neonates to their adulthood in order to determine the significance of fetal programming. An association between suboptimal fetal growth and a higher risk of metabolic syndrome, insulin resistance, diabetes type 2, and hypertension, has been proven by the studies conducted within different populations and age groups. Based on the evidence presented in this paper, it can be concluded that fetal programming has been recognized as significant and is on the way to becoming the third contributing factor in the development of chronic diseases during one's lifetime, along with a genetic predisposition and lifestyle.

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“…Such knowledge is critical to advancing health equity, given that adverse maternal and infant health outcomes disproportionately affect historically marginalized populations, particularly black women in the U.S [15,16]. Dozens of U.S.-based studies over the last decade have associated air pollution exposure with higher rates of adverse birth outcomes, including fetal growth restriction, low birth weight, spontaneous abortion, and preterm birth (reviewed in [17], see also [18]). Notably, most of these studies focus on populations that are predominantly white or hispanic, with small proportions of black women (e.g.…”

Section: Introductionmentioning

confidence: 99%

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*

Terrell,

St Julien,

Wallace

2024

Environ. Res.: Health

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Previous studies indicate that pollution exposure can increase risks of adverse birth outcomes, but Black communities are underrepresented in this research, and the potential moderating role of neighborhood context has not been explored. These issues are especially relevant in Louisiana, which has a high proportion of Black residents, an entrenched history of structural racism, the most pounds of toxic industrial emissions annually, and among the nation’s highest rates of low birthweight (LBW), preterm birth (PTB), and infant mortality. We investigated whether air pollution and social polarization by race and income (measured via the index of concentration at the extremes [ICE]) were associated with LBW and PTB among Louisiana census tracts (n = 1,101) using spatial lag models. Data sources included 2011-2020 birth records, U.S. Census Bureau 2017 demographic data, and 2017 Respiratory Hazard (RH) from the U.S. Environmental Protection Agency. Both RH and ICE were associated with LBW (z = 4.4, P < 0.0001; z = -27.0, P < 0.0001) and PTB (z = 2.3, P = 0.019; z = -16.7, P < 0.0001), with no interaction. Severely polluted tracts had 25% higher and 36% higher risks of LBW and PTB, respectively, versus unpolluted tracts. On average, 2,166 low birthweight and 3,583 preterm births annually were attributable to pollution exposure. Tracts with concentrated social deprivation (i.e. low ICE scores) had 53% higher and 34% higher risks of LBW and PTB, respectively, versus intermediate or mixed tracts. On average, 1,171 low birthweight and 1,739 preterm births annually were attributable to concentrated deprivation. Our ecological study found that a majority of adverse birth outcomes in Louisiana (i.e. 67% of LBW and PTB combined) are linked to air pollution exposure or disadvantage resulting from social polarization. These findings can inform research, policy, and advocacy to improve health equity in marginalized communities.

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Environmental factors affecting pregnancy outcomes

Cited by 6 publications

References 86 publications

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

Maternofetal interaction and modulation in creating a new population: A review of current evidence on the relationship between fetal nutrition and the development of chronic diseases later in life

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*

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Environmental factors affecting pregnancy outcomes

Cited by 6 publications

References 86 publications

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

Maternofetal interaction and modulation in creating a new population: A review of current evidence on the relationship between fetal nutrition and the development of chronic diseases later in life

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana *

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Product

Resources

About

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*