Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer

Diergaarde, Brenda; Braam, H.J.; Vasen, Hans F. A.; Nagengast, Fokko M.; Muijen, G.N.P. van; Kok, F.J.; Kampman, Ellen

doi:10.1016/j.cgh.2007.02.019

Cited by 66 publications

(62 citation statements)

References 34 publications

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“…We have shown that body mass index in early adulthood is similarly associated with CRC risk for both carriers and noncarriers (93). Studies of alcohol consumption (94), fruit consumption (95), dietary fiber intake (95), smoking (95,96) have not directly compared strengths of associations for carriers with noncarriers.…”

Section: Environmental Factorsmentioning

confidence: 99%

Risk Prediction Models for Colorectal Cancer: A Review

Win

MacInnis

Hopper

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Risk prediction models are important to identify individuals at high risk of developing the disease who can then be offered individually tailored clinical management, targeted screening and interventions to reduce the burden of disease. They are also useful for research purposes when attempting to identify new risk factors for the disease. In this article, we review the risk prediction models that have been developed for colorectal cancer and appraise their applicability, strengths, and weaknesses. We also discuss the factors to be considered for future development and improvement of models for colorectal cancer risk prediction. We conclude that there is no model that sufficiently covers the known risk factors for colorectal cancer that is suitable for assessment of people from across the full range of risk and that a new comprehensive model is needed. Cancer Epidemiol Biomarkers Prev; 21(3); 398-410. Ó2011 AACR.

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Section: Environmental Factorsmentioning

confidence: 99%

Risk Prediction Models for Colorectal Cancer: A Review

Win

MacInnis

Hopper

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…While studies point to the potential benefit of adopting healthy lifestyle behaviors to improve CRC prevention and control for both cancer survivors and those without a personal history of cancer [29][30][31], relatively little is known about the relationship between lifestyle behaviors with Lynch syndrome-associated cancer risks. The limited available data suggest that certain lifestyle factors, such as diet and smoking, may play a role in modifying cancer risk conferred by the highly penetrant MMR mutations that cause Lynch syndrome [32][33][34]. Although further research is needed in this area, there is expert agreement that advocating the potential benefits of dietary and lifestyle modifications to persons with Lynch syndrome is important to maintain overall health [6].…”

Section: Introductionmentioning

confidence: 95%

Health and lifestyle behaviors among persons at risk of Lynch syndrome

Burton

Peterson

Marani

et al. 2009

Cancer Causes Control

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“…With regards to LS, smoking has been associated with an increased risk of colorectal cancer risk [10,37] whereas Age at menarche (years, mean ± SD) 4 13.8 ± 1.6 14.2 ± 1. For example, the odds ratio for parity, would be the odds of ECC versus NEC for each extra child.…”

Section: Modifying Factors In Cancer Susceptibility Syndromesmentioning

confidence: 99%

“…ECC extracolonic cancer. NEC no extracolonic cancer 1 Data available for 87 mutation positive and 121 mutation negative females 2 Data available for 87 mutation positive and 121 mutation negative females 3 Data available for 80 mutation positive and 98 mutation negative females 4 Data available for 71 mutation positive and 16 mutation negative females 5 Data available for 55 mutation positive and 79 mutation negative females 6 Data available for 32 mutation positive and 42 mutation negative females 7 Data available for 41 mutation positive and 85 mutation negative females 8 Data available for 29 mutation positive and 67 mutation negative females fruit consumption, dietary fibre intake and the use of aspirin were found to be protective factors [6,10]. However, studies on the influence of consumption of alcohol, meat and complex starch found no significant associations with colorectal adenoma formation or cancer risk [5,36,37].…”

Section: Modifying Factors In Cancer Susceptibility Syndromesmentioning

confidence: 99%

“…This phenotypic heterogeneity has been attributed to genetic and allelic heterogeneity and the influence of sex, genetic modifiers and environmental factors [10,13,14,16,18,24,33,37]. Investigations regarding the influence of environmental factors on phenotypic expression in LS mutation carriers have been limited to colorectal cancer risk only, and the cohorts investigated were generally small [10,19,36,37].…”

Section: Introductionmentioning

confidence: 99%

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Lynch syndrome: the influence of environmental factors on extracolonic cancer risk in hMLH1 c.C1528T mutation carriers and their mutation-negative sisters

et al. 2010

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Lynch Syndrome (LS) is a cancer susceptibility syndrome caused mostly by mutations in the mismatch repair genes, hMLH1, hMSH2 and hMSH6. Mutation carriers are at risk of colorectal and endometrial cancer and, less frequently, cancer of the ovaries, stomach, small bowel, hepatobiliary tract, ureter, renal pelvis and brain. The influence of environmental factors on extracolonic cancer risk in LS patients has not been investigated thus far. The aim of this study was to investigate some of these factors in South African females carrying the hMLH1 c.C1528T mutation and their mutation-negative relatives. Data were collected from 87 mutation-positive females and 121 mutation-negative female relatives regarding age, cancer history, hormonal contraceptive use, parity, duration of breast feeding, height, weight and age at first birth, last birth, menarche and menopause. Influence of these factors on cancer risk was analysed by mixed-effects generalised linear models. Extracolonic cancer occurred in 14% (12/ 87) of mutation-positive females versus 7% (8/121) of mutation-negative females, (P = 0.0279, adjusted for age and relatedness between women). Breast cancer was the most common extracolonic cancer. An association was found for oral contraceptive use and extracolonic cancer risk in mutation-negative females only. No association was found for any of the other risk factors investigated, when adjusted for age. This might be due to the scarcity of extracolonic cancers in our data. Future knowledge on the influence of additional environmental factors on cancer risk in LS females can lead to evidence-based lifestyle advice for mutation carriers, thereby complementing the prevention strategies available today. In addition, it can contribute to an integrated model of cancer aetiology. Therefore, this study should be taken as a thrust for further research.

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Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer

Cited by 66 publications

References 34 publications

Risk Prediction Models for Colorectal Cancer: A Review

Risk Prediction Models for Colorectal Cancer: A Review

Health and lifestyle behaviors among persons at risk of Lynch syndrome

Lynch syndrome: the influence of environmental factors on extracolonic cancer risk in hMLH1 c.C1528T mutation carriers and their mutation-negative sisters

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