Environmental factors and gut microbiota: Toward better conservation of deer species

Wang, Yu; Xu, Bin; Chen, Huan; Yang, Fang; Huang, Jinlin; Jiao, Xinan; Zhang, Yunzeng

doi:10.3389/fmicb.2023.1136413

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…It is well-established that antibiotics greatly impact the structural composition of the gut microbiota (Wang et al 2023 ). For example, an 8-week amoxicillin treatment led to diminished levels of Faecalibaterium (Pallav et al 2014 ), as did the administration of ciprofloxacin (Stewardson et al 2015 ).…”

Section: Faecalibacterium As a Therapeutic Toolmentioning

confidence: 99%

Faecalibacterium: a bacterial genus with promising human health applications

Martín

Ríos-Covián

Huillet

et al. 2023

FEMS Microbiology Reviews

119

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In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).

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Section: Faecalibacterium As a Therapeutic Toolmentioning

confidence: 99%

Faecalibacterium: a bacterial genus with promising human health applications

Martín

Ríos-Covián

Huillet

et al. 2023

FEMS Microbiology Reviews

119

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“…1h-j). The results of these investigations demonstrated that, while there is a robust variation of the intestinal microbiota structure among patients subsets [25][26][27] , UC patients were characterized by a slight expansion of Proteobacteria and Actinobacteria phyla, with a decrease in Tenericutes and Verrucomicrobia (Fig. 1h).…”

Section: Introductionmentioning

confidence: 90%

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

Biagioli,

Di Giorgio,

Massa

et al. 2024

Preprint

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The interplay between the dysbiotic microbiota and bile acids is a critical determinant for development of a dysregulated immune system in inflammatory bowel disease (IBD). Here we have investigated the fecal bile acid metabolome, gut microbiota composition, and immune responses in IBD patients and murine models of colitis and found that IBD associates with an elevated excretion of primary bile acids while secondary, allo- and oxo- bile acids were reduced in both human and mice models of IBD. These changes correlated with the disease severity, mucosal expression of pro-inflammatory cytokines and chemokines, and reduced inflow of anti-inflammatory macrophages and Treg in the gut. Analysis of bile acids metabolome in the feces allowed the identification of five bile acids: 3-oxo-DCA, 3-oxo-LCA, allo-LCA, iso-allo-LCA and 3-oxo-UDCA, whose excretion was selectively decreased in IBD patients and diseased mice. By transactivation assay and docking calculations all five bile acids were shown to act as GPBAR1 agonists and RORγt inverse agonists, skewing Th17/Treg ratio and macrophage polarization toward an M2 phenotype. In a murine model of colitis, administration of 3-oxo-DCA suffices to reverse colitis development and intestinal dysbiosis in a GPBAR1-dependent manner.In vivoadministration of 3-oxo-DCA to colitic mice also reserves disease severity and RORγt activation induced by a RORγt agonist and IL-23, a Th17 inducing cytokine. These results demonstrated intestinal excretion of 3-oxoDCA, a dual GPBAR1 agonist and RORγt inverse agonist, is reduced in IBD and models of colitis and its restitution protects against colitis development, highlighting a potential role for this agent in IBD management.

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“…Conversely, its deregulation has been linked to pathological processes affecting several organs and apparatuses [ 91 ]. The GM composition is the result of an intense interplay between genetic and environmental factors, such as age, sex, perinatal feeding, dietary habits, lifestyle and antibiotic exposure [ 92 ].…”

Section: Gut Microbiota Gender and Vaccinesmentioning

confidence: 99%

Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective

Rio,

Caldarelli,

Chiantore

et al. 2024

Cells

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The development of preventive and therapeutic vaccines has played a crucial role in preventing infections and treating chronic and non-communicable diseases, respectively. For a long time, the influence of sex differences on modifying health and disease has not been addressed in clinical and preclinical studies. The interaction of genetic, epigenetic, and hormonal factors plays a role in the sex-related differences in the epidemiology of diseases, clinical manifestations, and the response to treatment. Moreover, sex is one of the leading factors influencing the gut microbiota composition, which could further explain the different predisposition to diseases in men and women. In the same way, differences between sexes occur also in the immune response to vaccines. This narrative review aims to highlight these differences, focusing on the immune response to vaccines. Comparative data about immune responses, vaccine effectiveness, and side effects are reviewed. Hence, the intricate interplay between sex, immunity, and the gut microbiota will be discussed for its potential role in the response to vaccination. Embracing a sex-oriented perspective in research may improve the efficacy of the immune response and allow the design of tailored vaccine schedules.

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Environmental factors and gut microbiota: Toward better conservation of deer species

Cited by 8 publications

References 49 publications

Faecalibacterium: a bacterial genus with promising human health applications

Faecalibacterium: a bacterial genus with promising human health applications

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective

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