Environmental Factors and Reproduction

Sutton, Patrice; Zlatnik, Marya G.; Woodruff, Tracey J.; Giudice, Linda C.

doi:10.1016/b978-0-323-47912-7.00019-6

Cited by 4 publications

(5 citation statements)

References 150 publications

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“…The low competent female gametes enclosed in EA follicles represent, indeed, a consistent amount of oocyte reserve, which can be derived directly from the ovary of several domestic animals collected to the slaughterhouse or, alternatively, derived by taking advantage of the progress in reproductive biotechnologies. Indeed, they can either survive after cryopreservation procedures [ 62 ] or obtain from the advanced protocol of in vitro folliculogenesis ( iv F) [ 63 , 64 , 65 ]. The possibility to draw on the gamete reserve present in follicles at an early stage of development reinforces the ART success in preserving human fertility [ 82 , 83 , 84 ] and, for what concerns the veterinary medicine field, in amplifying the heritage of genetically important livestock breeds [ 66 , 67 ] or in contrasting the threat of extinction of several endangered mammalian species [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…Improving the efficiency of IVM becomes still more relevant when the reproductive technology is applied to low-competent oocytes derived from early antral follicles, particularly those derived from IVFD or surviving after the cryopreservation of ovarian tissue [ 62 ]. The possibility of recapitulating the completion of meiosis and the developmental competence by maintaining genetic integrity in oocytes derived from early-stage follicles would surprisingly broaden the scope of application of IVM by answering the unresolved demand to succeed with ART in preserving women’s fertility [ 63 , 64 , 65 ] to amplify the heritage of genetically important livestock breeds [ 66 , 67 ] and to propagate endangered species [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

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IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture

Peserico

Berardino

Capacchietti

et al. 2023

IJMS

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In vitro maturation (IVM) is not a routine assisted reproductive technology (ART) for oocytes collected from early antral (EA) follicles, a large source of potentially available gametes. Despite substantial improvements in IVM in the past decade, the outcomes remain low for EA-derived oocytes due to their reduced developmental competences. To optimize IVM for ovine EA-derived oocytes, a three-dimensional (3D) scaffold-mediated follicle-enclosed oocytes (FEO) system was compared with a validated cumulus-oocyte complex (COC) protocol. Gonadotropin stimulation (eCG and/or hCG) and/or somatic cell coculture (ovarian vs. extraovarian-cell source) were supplied to both systems. The maturation rate and parthenogenetic activation were significantly improved by combining hCG stimulation with ovarian surface epithelium (OSE) cells coculture exclusively on the FEO system. Based on the data, the paracrine factors released specifically from OSE enhanced the hCG-triggering of oocyte maturation mechanisms by acting through the mural compartment (positive effect on FEO and not on COC) by stimulating the EGFR signaling. Overall, the FEO system performed on a developed reproductive scaffold proved feasible and reliable in promoting a synergic cytoplasmatic and nuclear maturation, offering a novel cultural strategy to widen the availability of mature gametes for ART.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture

Peserico

Berardino

Capacchietti

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Several groups have also put together valuable resources for clinicians to provide to patients and their families or to be accessed directly by the public. Some examples are [8]:…”

Section: Patient (And Clinician) Resourcesmentioning

confidence: 99%

“…EDCs are part of environmental chemical contaminants that are present in all populations studied [5], and it has been said that "babies are born pre-polluted" [6]. Exposures occur by ingestion, inhalation, trans-dermally, and trans-placentally, with greatest vulnerability pre-conceptually, during in utero development, neonatally, and in the adolescent period [7,8]. EDCs are distributed widely, contaminating our air, water, soil, and food, and there is now strong experimental and epidemiologic evidence that EDCs harm reproductive health and outcomes-specifically gametogenesis, embryogenesis, reproductive tract development, fertility, pregnancy outcomes, and child neurodevelopment, which may be preventable in some cases by adopting mitigating strategies [8][9][10][11][12].…”

mentioning

confidence: 99%

Talking with Patients and the Public About Endocrine-Disrupting Chemicals

Giudice

2023

Environment Impact on Reproductive Health

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Talking with patients and the public about endocrine-disrupting chemicals (EDCs) can be challenging for healthcare providers if they themselves are not well versed with the topic. Scientific and clinical evidence about environmental impacts on reproductive health have escalated exponentially over the past two decades, and this field can no longer be ignored or denied, as the consequences are significant, and many are preventable. EDCs are found in industrial- and e-waste, plastics, pesticides, preservatives, bedding, personal care products, household dust, diesel exhaust, air pollution, and humans and wildlife. They disrupt endocrine processes in the developing fetus, neonates, children, adolescents, and adults. These effects, along with lax toxicity regulations, make a compelling case for healthcare providers to understand the issues for appropriate counseling of patients and the public. Moreover, clinicians can also effectively advocate for change at governmental levels, complementing individual attempts to minimize personal risk. This chapter reviews recent advances enabling healthcare professionals in practice and in training to take an environmental history and talk with patients, the public, and policy makers about EDCs and resources to protect the reproductive health of this and future generations.

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“…There is emerging evidence that links exposure to toxic environmental agents and adverse reproductive and developmental health outcomes (4, 21–24). However, more research is needed to understand whether these associations are linked to causality and, if so, to determine the levels of exposure to guide recommendations for clinical interventions.…”

Section: Environmental Exposures and Outcomesmentioning

confidence: 99%

Reducing Prenatal Exposure to Toxic Environmental Agents

2021

Obstetrics &Amp; Gynecology

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There is emerging evidence that links exposure to toxic environmental agents and adverse reproductive and developmental health outcomes. Toxic exposures related to reproductive and developmental health primarily have been associated with infertility and miscarriage, obstetric outcomes such as preterm birth and low birth weight, neurodevelopmental delay such as autism and attention deficit hyperactivity disorder, and adult and childhood cancer. Although there is substantial overlap in the type of exposure and the associated health outcomes, for the purposes of this document, exposures generally can be grouped into the following categories: toxic chemicals, air pollution, and climate change-related exposures. Obstetric care clinicians do not need to be experts in environmental health science to provide useful information to patients and refer patients to appropriate specialists, if needed, when a hazardous exposure is identified. It is important for obstetrician–gynecologists and other obstetric care clinicians to become knowledgeable about toxic environmental exposures that are endemic to their specific geographic areas, such as local water safety advisories (eg, lead-contaminated water), local air quality levels, and patients’ proximity to power plants and fracking sites. Although exposure to toxic environmental agents is widespread across populations, many environmental factors that are harmful to reproductive health disproportionately affect underserved populations and are subsumed in issues of environmental justice. Clinical encounters offer an opportunity to screen and counsel patients during the prepregnancy and prenatal periods—particularly individuals most disproportionately affected—about opportunities to reduce toxic environmental health exposures. This Committee Opinion is revised to integrate more recent literature regarding reducing prepregnancy and prenatal toxic environmental exposures.

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Environmental Factors and Reproduction

Cited by 4 publications

References 150 publications

IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture

IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture

Talking with Patients and the Public About Endocrine-Disrupting Chemicals

Reducing Prenatal Exposure to Toxic Environmental Agents

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