Environmental factors contributing to the development of childhood leukemia in children with Down's syndrome

Mejı́a-Aranguré, Juan Manuel; Fajardo-Gutiérrez, Arturo; Flores-Aguilar, Hilario; Martínez-García, M C; Salamanca-Gómez, F; Palma-Padilla, Virginia; Paredes‐Aguilera, Rogelio; Bernáldez-Rı́os, Roberto; Ortíz-Fernández, Antonio; Martı́nez-Avalos, Armando; Gorodezky, Clara

doi:10.1038/sj.leu.2403047

Cited by 31 publications

(23 citation statements)

References 8 publications

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“…This is the largest case -control study of leukaemia in children with DS yet conducted (Garre et al, 1987;Mejia-Arangure et al, 2003) and the first to evaluate whether the timing of common infections is associated with a reduced risk of acute leukaemia in children with DS. Infections in the first 2 years of life were associated with a reduced risk of acute leukaemia among children with DS.…”

Section: Discussionmentioning

confidence: 99%

Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group

et al. 2004

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Children with Down syndrome (DS) are highly susceptible to acute leukaemia. Given the potential role of infections in the aetiology of leukaemia in children without DS, we investigated whether there was an association between early-life infections and acute leukaemia in children with DS. Maternal infections during pregnancy were also examined. We enrolled 158 incident cases of acute leukaemia in children with DS (97 acute lymphoblastic leukaemia (ALL) and 61 acute myeloid leukaemia (AML)) diagnosed at Children's Oncology Group institutions between 1997 and 2002. DS controls (N ¼ 173) were selected from the cases' primary care clinics and frequency matched on age at leukaemia diagnosis. Data were collected on demographics, child's medical history, mother's medical history, and other factors by maternal interview. Analyses were conducted using unconditional logistic regression adjusted for potential confounders. A significant negative association was observed between acute leukaemia and any infection in the first 2 years of life (adjusted odds ratio (OR) ¼ 0.55, 95% confidence interval (CI) (0.33 -0.92); OR ¼ 0.53, 95% CI (0.29 -0.97); and OR ¼ 0.59, 95% CI (0.28 -1.25) for acute leukaemia combined, ALL, and AML respectively). The association between acute leukaemia and maternal infections during pregnancy was in the same direction but not significant. This study offers support for the hypothesis that early-life infections may play a protective role in the aetiology of acute leukaemia in children with DS.

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Section: Discussionmentioning

confidence: 99%

Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group

et al. 2004

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“…Two studies were on children with DS and reported data on GL only (33,36). Eight studies were conducted in Europe (22, 24, 27, 28, 34, 35, 38, 41), eight in the United States and/or Canada and Australia (23,25,26,29,31,32,36,40), two in Mexico or Costa Rica (33,39), one in Japan (37), one in Taiwan (42) and one was international (30) involving eight countries. Control subjects were population-based in 15 studies and they were matched to cases on age, gender, and residence in most studies.…”

Section: Resultsmentioning

confidence: 99%

“…In seven of these, only acute leukemia was investigated (25,28,33,34,36,38,40), in three studies (26,30,39), a small percentage of other leukemias were also included, and in two studies (27,31), the leukemia type was not specified. Overall, the proportion of cases with ALL in these studies ranged from 36% to 89%.…”

Section: Resultsmentioning

confidence: 99%

Maternal Alcohol Consumption during Pregnancy and Risk of Childhood Leukemia: Systematic Review and Meta-analysis

Latino‐Martel

Chan

Druesne-Pecollo

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Leukemia is the most frequently occurring cancer in children. Although its etiology is largely unknown, leukemia is believed to result from an interaction between genetic and environmental factors. Among different potential risk factors, the possible role of maternal alcohol consumption during pregnancy has been questioned.Methods: To assess the association between maternal alcohol consumption during pregnancy and childhood leukemia, a systematic review and meta-analysis of published studies was done.Results: Twenty-one case-control studies were included in categorical and dose-response meta-analyses. No cohort study was identified. Analyses were conducted by type of leukemia, children's age at diagnosis, and type of alcoholic beverage and trimester of pregnancy at alcohol use. Alcohol intake during pregnancy (yes versus no) was statistically significantly associated with childhood acute myeloid leukemia (AML) [odds ratio (OR), 1.56; 95% confidence interval (CI), 1.13-2.15] but not with acute lymphoblastic leukemia (OR, 1.10; 95% CI,. Heterogeneity between studies was observed. The OR of AML for an increase of a drink per week was 1.24 (95% CI, 0.94-1.64). The association of alcohol intake during pregnancy with AML was observed for cancers diagnosed at age 0 to 4 years (OR, 2.68; 95% CI, 1.85-3.89) in five studies without heterogeneity (I 2 ≤ 0.1%).

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“…In the study of Down Syndrome children (Mejía-Aranguré et al, 2003), the adjustment models did not show any interaction between paternal alcoholism and smoking. Menegaux et al (2005) examined the association of parental smoking and maternal alcohol and coffee intake during pregnancy with the risk for childhood leukaemia.…”

Section: (B) Potential Confoundersmentioning

confidence: 99%

“…Down Syndrome children are highly susceptible to the development of acute leukaemia. In a case-control study of 27 children with acute leukaemia and Down Syndrome compared with 58 Down Syndrome children without acute leukaemia Mejía-Aranguré et al (2003) found that paternal smoking of more than 10 cigarettes/ day, both preconception and after birth of the index child was associated with acute leukaemia. In the UKCC case-control study , paternal but not maternal preconception tobacco smoking of 1-19 cigarettes/day was associated with an increased risk of leukaemia, and a similar pattern was reported for lymphoma.…”

Section: (A) Duration and Intensity Of Exposurementioning

confidence: 99%

Secondhand Tobacco Smoke

2011

Encyclopedia of Cancer

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Environmental factors contributing to the development of childhood leukemia in children with Down's syndrome

Cited by 31 publications

References 8 publications

Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group

Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group

Maternal Alcohol Consumption during Pregnancy and Risk of Childhood Leukemia: Systematic Review and Meta-analysis

Secondhand Tobacco Smoke

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