Outpatients who fail to attend their appointments have a negative impact on the healthcare outcome. Thus, healthcare organizations facing new opportunities, one of them is to improve the quality of healthcare. The main challenges is predictive analysis using techniques capable of handle the huge data generated. We propose a big data framework for identifying subject outpatients’ no-show via feature engineering and machine learning (MLlib) in the Spark platform. This study evaluates the performance of five machine learning techniques, using the (2,011,813, 19) outpatients’ visits data. Conducting several experiments and using different validation methods, the Gradient Boosting (GB) performed best, resulting in an increase of accuracy and ROC to 79% and 81%, respectively. In addition, we showed that exploring and evaluating the performance of the machine learning models using various evaluation methods is critical as the accuracy of prediction can significantly differ. The aim of this paper is exploring factors that affect no-show rate and can be used to formulate predictions using big data machine learning techniques