Environmental fate and pharmacokinetics of sulphamethazine in<i>Fenneropenaeus chinensis</i>shrimp production systems after oral administration

Sun, Ming; Li, Jian; Zhai, Qianqian; Ge, Qianqian; Li, Jitao; Zhao, Fazhen; Chang, Zhiqiang; Ya, HE

doi:10.1111/are.12803

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Till now, there is no related research on pharmacokinetic of eugenol in shrimps. Lots of pharmacokinetics studies in shrimp were related to the antibacterial agents, such as oxytetracycline in white shrimp and black tiger shrimp [ 49 , 50 ], sulfamethoxazole and enrofloxacin in Pacific white shrimp [ 19 , 51 ], sulphamethazine in Fenneropenaeus chinensis shrimp [ 52 ] and oxolinic acid in kuruma shrimp [ 53 ]. Hence, in the present study, pharmacokinetics and residue eliminations of eugenol in Pacific white shrimp were firstly investigated using GC-MS/MS.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics studies of eugenol in Pacific white shrimp (Litopenaeus vannamei) after immersion bath

et al. 2022

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Background Eugenol is the most commonly used plant anesthetic to relieve the stressors during various aquaculture procedures. This study aims to investigate the pharmacokinetics of eugenol in Pacific white shrimp by immersion baths in a simulated transportation. Results The pharmacokinetics of eugenol were firstly investigated in Pacific white shrimp by immersion baths of 300 mg L− 1 eugenol over 5 min (Treatment 1), 10 mg L− 1 eugenol during 24 h (Treatment 2) and a sequential immersion administration (Treatment 3). Concentrations of eugenol in hemolymph, hepatopancreas, and muscle were determined using Gas chromatography-tandem mass spectrometry (GC-MS/MS). After immersion bath of Treatment 1, the elimination half-life (t1/2z) values are 1.3 h and 11 h for hepatopancreas and muscles, indicating the rapid absorption and elimination of eugenol in shrimp. Under the Treatment 2 administration, the eugenol peak concentration is 6527.9 μg/kg in muscle, followed by 402.8 μg/kg in hepatopancreas, with the lowest concentration of 37.9 μg/L in hemolymph. Area under the curve (AUC0-∞) values lie in the order of muscle > hepatopancreas > hemolymph, suggesting that eugenol tends to accumulate in muscle by the immersion administration. Moreover, the average residence time (MRT0-∞) values of 38.6, 23.0 and 115.3 h for hemolymph, hepatopancreas and muscle are achieved, which may indicate that hepatopancreas is the main organ for elimination of eugenol. After combining the conditions in a sequential bath immersion of eugenol (Treatment 3), the maximum concentration (Cmax) values of eugenol are higher than those achieved in Treatment 2, indicating that accumulation of eugenol happened in haemolymph, hepatopancreas and muscle. In addition, the corresponding t1/2z values are 4.7, 14.9 and 47.6 h, respectively, suggesting the faster elimination from the tissues following sequential administration. After the immersion bath, eugenol concentrations in muscle of Pacific white shrimp are lower than 2.5 mg/kg at 2 h, 48 h and 24.5 h in Treatment 1 ~ 3. Conclusions A withdrawal period of 2 h, 48 h and 24.5 h following a 300 mg L− 1 of eugenol over a 5-min, 10 mg L− 1 eugenol concentration during a 24-h and combined conditions in a sequential immersion bath were suggested.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics studies of eugenol in Pacific white shrimp (Litopenaeus vannamei) after immersion bath

et al. 2022

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“…Regarding SAs, numerous PK profile studies have been reported in various aquatic animal species, namely shrimp ( Fenneropenaeus chinensis ) [ 12 ], summer flounder ( Paralichthys dentatus ) [ 13 ], walleye ( Sander vitreus ) [ 13 ], eel ( Anguilla anguilla ) [ 14 ], rainbow trout ( Oncorhynchus mykiss ) [ 15 ], yellowtail ( Seriola quinqueradiata ) [ 15 ], Atlantic salmon ( Sdmo sahr ) [ 16 ], and penaeid shrimp ( Penaeus vannamei ) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of sulfamonomethoxine in tilapia (Oreochromis niloticus × Oreochromis mossambicus) by liquid chromatography-tandem mass spectrometry and its application pharmacokinetics study

Kung

Lee

Wang

2019

Journal of Food and Drug Analysis

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A precise and reliable analytical method to measure trace levels of sulfamonomethoxine (SMM) and N 4 -acetyl metabolite in tilapia samples using liquid chromatography-tandem mass spectrometry was developed. Optimized chromatographic separation was performed on C18 reversed-phase columns using gradient elution with methanol and 5 mmol/L of an ammonium acetate aqueous solution (adjusted to pH 3.5 using formic acid). This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N 4 -acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg −1 body weight of orally administered SMM. Blood and tissues were collected between 0.5 and 192 h with 14 total sampling time points. SMM was rapidly absorbed, and extensively distributed in the bile and liver through systemic circulation. Enterohepatic circulation of SMM was observed in the tilapia body. Acetylation percentages were 45% (blood), 90% (liver), 62% (kidney), 98% (bile), and 52% (muscle). High concentrations of AC-SMM accumulated in the tilapia bile. At 192 h, AC-SMM concentration in the bile remained at 4710 μg kg −1 . The k e value of AC-SMM (0.015 h −1 ) in the blood was lower than that of SMM (0.032 h −1 ). This study demonstrated effective residue monitoring and determined the pharmacokinetic properties of SMM and AC-SMM in tilapia.

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“…It has been previously shown that sulfa drugs can accumulate in this organ in Fenneropenaeus chinensis and Eriocheir sinensis (Yin et al, 2004;Zhang et al, 2005;Tang et al, 2006). Gills exhibit high drug concentration, because of their continuous contact with the systemic circulation (Sun et al, 2015). The shell that contains about 20% chitin, poly-b(1-4)-N-acetyl-D-glucosamine, which has many applications in food and pharmaceutical industrials (Percot et al, 2003), is also able to retain the drug thanks to the chelation property of chitin.…”

mentioning

confidence: 99%

Sulfadimethoxine in giant freshwater prawns (Macrobrachium rosenbergii): an attempt to estimate the withdrawal time by a population pharmacokinetic approach

Poapolathep

Giorgi

Toutain

et al. 2016

Vet Pharm & Therapeutics

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The fates of sulfadimethoxine (SDM) for different routes of administration were investigated in muscle tissue of giant freshwater prawns, Macrobrachium rosenbergii, following either intramuscular (i.m.) or gavage administration at a dosage of 50 mg/kg body weight (b.w.). The depletion patterns of SDM were also examined after medicated feed treatment at the feeding concentration of 10 g/kg of feed twice a day at a rate of 1% of total b.w. for five consecutive days. The concentration of SDM in prawn muscle tissue was measured using a high-performance liquid chromatography (HPLC) equipped with ultraviolet detector. Noncompartmental analyses were used to estimate basic pharmacokinetic parameters for the i.m. and gavage data, while a population model was developed to analyze the entire data set including the feed group. Using the Monte Carlo simulations, the withdrawal times (WT) for the orally administered SDM in feed supplement were determined. Maximum concentration of SDM was significantly higher in the i.m. than in the gavage group, and the area under the curve (AUC) value for relative bioavailability following gavage administration was 25.6%. Using Monte Carlo simulation, for a maximum residue limit (MRL) of 0.1 μg/g, the WT for muscle after oral administration of SDM in feed was estimated to be 67 h, while for a MRL of 0.2 μg/g, the WT was estimated to be of 54 h.

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Environmental fate and pharmacokinetics of sulphamethazine inFenneropenaeus chinensisshrimp production systems after oral administration

Cited by 6 publications

References 33 publications

Pharmacokinetics studies of eugenol in Pacific white shrimp (Litopenaeus vannamei) after immersion bath

Pharmacokinetics studies of eugenol in Pacific white shrimp (Litopenaeus vannamei) after immersion bath

Determination of sulfamonomethoxine in tilapia (Oreochromis niloticus × Oreochromis mossambicus) by liquid chromatography-tandem mass spectrometry and its application pharmacokinetics study

Sulfadimethoxine in giant freshwater prawns (Macrobrachium rosenbergii): an attempt to estimate the withdrawal time by a population pharmacokinetic approach

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