Environmental health risks induced by interaction between phthalic acid esters (PAEs) and biological macromolecules: A review

Wang, Zeming; Ma, Junchao; Wang, Tingting; Qin, Chao; Hu, Xiaojie; Mosa, Ahmed; Ling, Wanting

doi:10.1016/j.chemosphere.2023.138578

Cited by 35 publications

(6 citation statements)

References 111 publications

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“…PAEs include high-molecular-weight compounds such as diisodecyl phthalate (DIDP) and diisononyl phthalate (DINP); intermediate compounds like butyl benzyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP); and low-molecular-weight compounds including diethyl phthalate (DEP) and di-n-butyl phthalate (DAP) ( Kıralan, 2020 ). PAEs contaminate the air, soil, and natural water, and exposure to PAEs can occur through ingestion, inhalation, or skin absorption ( Wang et al, 2023 ). The biological half-life of PAEs is short (<24 h), and the rapid biotransformation of PAEs into biologically active monoesters, which exhibit greater toxicity than their parent compounds, raises concerns regarding their short-term effects and long-term implications on human health, particularly in the realm of female reproductive health.…”

Section: Reproductive Toxicity Of Phthalic Acid Estersmentioning

confidence: 99%

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Wang,

Zhao,

Feng

et al. 2024

Front. Cell Dev. Biol.

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Recently, there has been a noticeable increase in disorders of the female reproductive system, accompanied by a rise in adverse pregnancy outcomes. This trend is increasingly being linked to environmental pollution, particularly through the lens of Endocrine Disrupting Chemicals (EDCs). These external agents disrupt natural processes of hormones, including synthesis, metabolism, secretion, transport, binding, as well as elimination. These disruptions can significantly impair human reproductive functions. A wealth of animal studies and epidemiological research indicates that exposure to toxic environmental factors can interfere with the endocrine system’s normal functioning, resulting in negative reproductive outcomes. However, the mechanisms of these adverse effects are largely unknown. This work reviews the reproductive toxicity of five major environmental EDCs—Bisphenol A (BPA), Phthalates (PAEs), Triclocarban Triclosan and Disinfection Byproducts (DBPs)—to lay a foundational theoretical basis for further toxicological study of EDCs. Additionally, it aims to spark advancements in the prevention and treatment of female reproductive toxicity caused by these chemicals.

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Section: Reproductive Toxicity Of Phthalic Acid Estersmentioning

confidence: 99%

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Wang,

Zhao,

Feng

et al. 2024

Front. Cell Dev. Biol.

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“…Embora a infertilidade seja uma condição patológica multifatorial, os ftalatos estão mundialmente implicados no declínio da fertilidade masculina. Os ftalatos são considerados tóxicos não só para roedores e peixes, mas também para a reprodução humana (Adegoke et al, 2023, Batista-Silva et al, 2020Wang et al, 2023). O BEHP induz conhecida toxicidade no sistema genital masculino como o dano testicular e infertilidade, disfunção na espermatogênese e síndrome da disgenesia testicular, caracterizada por hipospadia (abertura anormal da uretra peniana), criptorquidia, baixa qualidade do sêmen e câncer testicular, em fetos de gestantes expostas ao ftalato (Lin et al, 2023).…”

Section: Palavras-chaveunclassified

“…Nesta mesma linha de estudos, foi analisada a correlação de uma mistura contendo 6 tipos de parabenos e 7 tipos de bisfenóis na urina de 205 indivíduos entre 5 e 12 anos de idade. A análise final corrobora os resultados relatados para protocolos semelhantes os quais indicam que tanto individualmente como uma mistura destes compostos induzem uma diminuição na capacidade respiratória pulmonar(Hu et al, 2023).De forma geral, estes resultados recentes adquiridos de protocolos conduzidos em humanos, apontam para o papel tóxico dos parabenos, incluindo o desenvolvimento de câncer.3. CONCLUSÃOA família dos parabenos se classificam como metil-, etil, propil-, isopropile butilparabenos de acordo com a esterificação na cadeia alquil ou aril.…”

unclassified

“…Desta forma, correspondente, que é considerado biologicamente ativo. A atividade de catálise enzimática por lipases e esterases é crucial neste processo.Na reação de segunda fase ou fase II ocorre a conjugação enzimática com o ácido glicurônico, pela ação da uridina difosfato glicuronil transferase (UDPglicuronil transferase), o que torna este composto de mais fácil excreção pelas fezes(Wang et al, 2023).…”

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Bisfenol A: Uma Ameaça Aos Hormônios Sexuais

Pereira,

Oliveira,

Moreira

et al. 2024

Emergentes Ambientais: Alerta À Proteção Da Saúde

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“…Low-molecular-weight phthalates, such as di-n-butyl phthalate (DBP) and di-isobutyl phthalate (DiBP), are present in fragrances, pharmaceuticals, cosmetics, personal-care products, and packaging materials, whereas high-molecular-weight phthalates, such as di-2-ethylhexyl phthalate (DEHP) and benzyl-n-butyl ortho-phthalate (BBP), are used to soften plastics, particularly PVC building materials [ 7 , 8 ]. Phthalates are not covalently bound to other substances and can easily permeate and migrate into environmental media, as result, the general population is ubiquitously exposed to phthalates via oral, dermal, inhalation, and intravenous routes [ 9 , 10 ]. Phthalate metabolites have been consistently detected in urine from the general population including pregnant women worldwide [ 7 – 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

Li,

Kang,

Liu

et al. 2024

BMC Pregnancy Childbirth

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Background The majority of congenital heart diseases (CHDs) are thought to result from the interactions of genetics and the environment factors. This study aimed to assess the association of maternal non-occupational phthalates exposure, metabolic gene polymorphisms and their interactions with risk of CHDs in offspring. Methods A multicenter case-control study of 245 mothers with CHDs infants and 268 control mothers of health infant was conducted from six hospitals. Maternal urinary concentrations of eight phthalate metabolites were measured by ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Twenty single nucleotide polymorphisms (SNPs) in cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and 19 (CYP2C19), uridine diphosphate (UDP) glucuronosyl transferase family 1 member A7 (UGT1A7), family 2 member B7 (UGT2B7) and B15(UGT2B15) genes were genotyped. The multivariate logistic regressions were used to estimate the association between maternal phthalates exposure or gene polymorphisms and risk of CHDs. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the gene–gene and gene–phthalates exposure interactions. Results There was no significant difference in phthalate metabolites concentrations between the cases and controls. No significant positive associations were observed between maternal exposure to phthalates and CHDs. The SNPs of UGT1A7 gene at rs4124874 (under three models, log-additive: aOR = 1.74, 95% CI:1.28–2.37; dominant: aOR = 1.86, 95% CI:1.25–2.78; recessive: aOR = 2.50, 95% CI: 1.26–4.94) and rs887829 (under the recessive model: aOR = 13.66, 95% CI: 1.54–121) were significantly associated with an increased risk of CHDs. Furthermore, the associations between rs4124874 (under log-additive and dominant models) of UGT1A7 were statistically significant after the false discovery rate correction. No significant gene-gene or gene-phthalate metabolites interactions were observed. Conclusions The polymorphisms of maternal UGT1A7 gene at rs4124874 and rs887829 were significantly associated with an increased risk of CHDs. More large-scale studies or prospective study designs are needed to confirm or refute our findings in the future.

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Environmental health risks induced by interaction between phthalic acid esters (PAEs) and biological macromolecules: A review

Cited by 35 publications

References 111 publications

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Bisfenol A: Uma Ameaça Aos Hormônios Sexuais

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

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