The paper introduces a new semi-probabilistic methodology for the definition of energy fragility curves suitable for a macro-classification of building stock inspired to and coupled with the widely adopted method of seismic fragility curves. The approach is applied to the reinforced concrete residential buildings of the Italian stock. Starting from a classification according to the climatic zone and the construction period, some reference buildings in terms of building envelope typologies have been defined and simulated by means of dynamic modeling tools. Then, cumulative distributions of the probability that the primary energy consumption for heating was comparable with certain threshold values are defined according to the climatic conditions expressed with the heating degree days, which constitute the intensity measure for the fragility curves. Finally, by focusing on the interaction points between structural and energetic aspects, it is shown how these curves can be useful for decision-makers with regards to definition of importance and or the level of intervention to be made to the building envelope for improving its seismic safety and the energy quality. Indeed, non-integrated interventions are more expensive and less efficient.