Environmental hormesis: New developments

Agathokleous, Evgenios; Calabrese, Edward J.; Barceló, Damià

doi:10.1016/j.scitotenv.2023.167450

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Applying a = 0.0509 and R = 27.1% to Equation (4), Equation ( 27) (Figure 6, red line) was obtained. From Figure 6, Equation (27) shows that the risk increased linearly with the dose when a 10% error was allowed in R: 13) is multiplied by 0.1 and falls within the lower limit of 10% error of the proportional line (black linear line "linear * 0.9") in the all-dose range. The purple curved line indicates the function R when K in Equation ( 13) is multiplied by 0.25, and the blue curved line when multiplied by 0.5.…”

Section: Conclusion Problems and Implicationsmentioning

confidence: 96%

“…Applying a = 0.0509 and R = 27.1% to Equation (4), Equation ( 27) (Figure 6, red line) was obtained. From Figure 6, Equation (27) shows that the risk increased linearly with the dose when a 10% error was allowed in R: R = 30 + 0.005E − 0.417Ee −0.0509E (27) error in Equation ( 1) at 20 mSv and the risk must be at least 27.1%. Applying a = 0.0509 and R = 27.1% to Equation (4), Equation ( 27) (Figure 6, red line) was obtained.…”

Section: Conclusion Problems and Implicationsmentioning

confidence: 99%

“…Our current study finds the possibility of banning the use of LNT. Radiation-adaptive responses have been reported as reductions of detrimental effects at low doses [19][20][21][22][23][24][25][26][27][28][29][30][31], and radiation hormesis as the hypothesis that low-dose radiation is beneficial to an organism [32][33][34][35][36][37][38][39][40]. The bystander effect [9,24,25,31,34,35,[41][42][43][44][45][46][47][48][49][50][51][52] and genomic instability [9,15,[24][25][26]30,31,34,[41]…”

Section: Introductionmentioning

confidence: 99%

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Calculations of the Radiation Dose for the Maximum Hormesis Effect

Kino

2024

Radiation

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To date, the radiation-adaptive response has been reported as a low-dose-related phenomenon and has been associated with radiation hormesis. Well-known cancers are caused by non-radiation active reactants, in addition to radiation. A model of suppression for radiation-specific cancers was previously reported, but the model did not target radiation-nonspecific cancers. In this paper, we describe kinetic models of radiation-induced suppressors for general radiation non-specific cancers, estimating the dose M that induces the maximum hormesis effect while satisfying the condition that the risk is approximately proportional to a dose above NOAEL (No Observed Adverse Effect Level). The radiation hormesis effect is maximal when the rate constant for generation of a risk-reducing factor is the same as the rate constant for its decomposition. When the two rate constants are different, the dose M at which the radiation hormesis effect is maximized depends on both rate constants, but the dose M increases as the two rate constants approach each other, reaching a maximum dose. The theory proposed in this paper can only explain existing experiments with extremely short error bar lengths. This theory may lead to the discovery of unknown risk-reducing factor at low doses and the development of risk-reducing methods in the future.

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Section: Conclusion Problems and Implicationsmentioning

confidence: 96%

“…Applying a = 0.0509 and R = 27.1% to Equation (4), Equation ( 27) (Figure 6, red line) was obtained. From Figure 6, Equation (27) shows that the risk increased linearly with the dose when a 10% error was allowed in R: R = 30 + 0.005E − 0.417Ee −0.0509E (27) error in Equation ( 1) at 20 mSv and the risk must be at least 27.1%. Applying a = 0.0509 and R = 27.1% to Equation (4), Equation ( 27) (Figure 6, red line) was obtained.…”

Section: Conclusion Problems and Implicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Calculations of the Radiation Dose for the Maximum Hormesis Effect

Kino

2024

Radiation

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“…Therefore, it is difficult to statistically evaluate the probability of cancer occurrence at doses below 100 mSv, so whether the risk is increased or decreased is not known [2][3][4][5][6][7][8][9][10]. Radiation adaptation responses have been reported as a phenomenon associated with low doses [11][12][13][14][15][16][17][18][19] and are closely related to radiation hormesis [20][21][22][23][24][25][26][27][28], the hypothesis that low-dose radiation is beneficial to an organism. Thus, biological findings and mathematical models at the molecular-cellular level have been studied to unravel the mysteries of low-dose exposure [20,[29][30][31][32][33][34][35][36][37], and we have previously proposed a linear-hormesis coupling theory.…”

Section: Introductionmentioning

confidence: 99%

The Theoretical Dose That Exerts the Maximum Hormesis Effect Is 20 mSv When the Risk Is Approximately Proportional to Dose above 100 mSv.

Kino

2023

Preprint

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To date, radiation adaptation response has been reported as a low-dose related phenomenon and has been associated with radiation hormesis. Well-known cancers are caused by non-radiation active reactants, in addition to radiation. A model of suppression for radiation-specific cancers was previously reported, but the model did not target radiation-nonspecific cancers. In this paper, we describe kinetic models of radiation-induced suppressors for general radiation non-specific cancers, estimating the dose that induces the maximum hormesis effect while satisfying the condition that the risk is approximately proportional to dose above 100 mSv. It was found that the radiation hormesis effect is maximal at about 20 mSv when the rate constant for generation is the same as the rate constant for decomposition. When the two rate constants are different, the dose at which the radiation hormesis effect is maximized depends on both rate constants, but the dose increases as the two rate constants approach each other, reaching a maximum of about 20 mSv. This conclusion may lead to the discovery of unknown cancer suppressors at low doses and the development of cancer suppression methods in the future.

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