Based on the spatial econometric model, this paper mainly studies the impact of the utilization of mineral resources on environmental pollution and the impact of environmental regulation on the utilization of mineral resources in 30 provincial regions from 2003 to 2016, and analyzes the impact mechanism of heterogeneity and synergy. The results show that the utilization of mineral resources intensifies the degree of environmental pollution and the degree of economic spatial agglomeration, while environmental regulation can effectively restrain the utilization of mineral resources in the region and the near adjacent areas. Through the analysis results of synergistic mechanism, it can be seen that the improvement of industrial structure alleviates the impact of the utilization of mineral resources on environmental pollution and the restraining effect of environmental regulation on it. The improvement of technological progress has improved the environmental pollution caused by the utilization of mineral resources in this area, but intensified the environmental pollution degree of the utilization of mineral resources in neighboring areas. In the current technological level, the neighboring areas will consume more mineral resources to meet a certain demand, thus aggravating the environmental pollution of the utilization of mineral resources in the neighboring areas. The enhanced intensity of government management significantly improves the pollution control efficiency of environmental regulation on the utilization of mineral resources.