Environmental influences on childhood asthma: Allergens

Čustović, Adnan; Moira, Angela Pinot de; Murray, Clare; Simpson, Angela

doi:10.1111/pai.13915

Cited by 22 publications

(26 citation statements)

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“…Food‐related allergic reactions decrease with age and are associated with tolerance to common allergenic foods 8 . Later, due to the increase of children's outdoor activities, microbial exposure and some other factors, the positivity of inhaled allergen increased 9 …”

Section: Discussionmentioning

confidence: 99%

“…8 Later, due to the increase of children's outdoor activities, microbial exposure and some other factors, the positivity of inhaled allergen increased. 9 An analysis of allergen detection of 930 allergic patients (0-85 years old) in Zhangzhou (a city in Southern China) in 2017, 10 an analysis of 731 patients (3-month-old to 85 years old) in Zhengzhou (a city in the middle area of China) in 2018, 11 and an analysis of 11,641 patients (1-month-old to 98 years old) in Beijing (a city in northern China) from 2013 to 2017 12 all showed that the positive rate of inhalation allergen was higher than that of ingestion allergen before. In this study, the sIgE-positive rate of ingestion allergen was significantly higher than that of inhalation allergen.…”

Section: The Potential Reasons For the Significant Difference Observe...mentioning

confidence: 99%

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A multicenter analysis on the changes of sIgE in China during the early period of COVID‐19 pandemic

Li,

2023

Immunity Inflam & Disease

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ObjectiveThis study aims to analyze the changes in allergen composition ratio during the early stages of the COVID‐19 outbreak in China and analyze the underlying factors contributing to these alterations.MethodsA multicenter study approach was employed. A total of 618 male and female patients (0–89 years old) were recruited from the dermatology, pediatrics, and allergy departments of 17 hospitals across 15 Chinese cities between January 2020 and June 2021. Serum samples were collected and subjected to allergen‐specific immunoglobulin E (sIgE) detection using the reversed enzyme allegro‐sorbent test. The allergens included Dermatophagoides pteronyssinus (D. pteronyssinus), Dermatophagoides farina (D. farina), Ambrosia artemisiifolia (A. artemisiifolia), Salix babylonica (S. babylonica), dog dander, alternaria, cockroach, Artemisia argyi (A. argyi), cat dander, house dust, milk, hen's egg, mutton, cod, peanut, beef, soybean, shrimp, crab, and wheat. Each participant was required to exhibit at least one positive sIgE detection result (≥0.35 IU/mL). The chi‐square test was used to analyze the differences between groups.ResultsThe positive sIgE proportion of inhalation allergens were significantly lower than that of ingestion allergens. As restrictions on outdoor activities and seafood imports persisted, the positive sIgE proportion of wheat and shrimp exhibited a significant decrease in the spring of 2021 compared to the corresponding period in 2020. Conversely, there was a substantial increase in the positive proportion of crab. The fluctuation in the ratio of D. pteronyssinus and D. farina appeared to be influenced more by seasonal factors rather than the COVID‐19 pandemic. However, no noteworthy disparities were observed in the proportions of other allergens.ConclusionThe alterations in allergen composition during the initial phase of the epidemic may be attributed to several factors, such as decreased travel, increased mask usage, reduced carbohydrate consumption, and changes in seafood consumption. However, factors such as season, cultural practices, and customs may also influence the composition of allergens.

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Section: Discussionmentioning

confidence: 99%

Section: The Potential Reasons For the Significant Difference Observe...mentioning

confidence: 99%

A multicenter analysis on the changes of sIgE in China during the early period of COVID‐19 pandemic

Li,

2023

Immunity Inflam & Disease

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“…Tomando como base lo publicado por Mallol J et al (11) , con un total de 1100 pacientes pediátricos con asma y rinitis, y un intervalo de confianza del 95%, se consideró una n=86 como tamaño de la muestra para la realización de este estudio, cálculo realizado por Epi Info Versión 3.5.4. El estudio fue aprobado por el comité de ética de la Investigación de la FCMUNA.…”

Section: Materiales Y Métodosunclassified

Sensibilización cutánea a aeroalérgenos en niños con rinitis y asma

Pérez Ortiz,

Campuzano de Colón,

Alcaraz Duarte

et al. 2023

An. Fac. Cienc. Méd. (Asunción)

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Introducción: Las enfermedades alérgicas son muy comunes en la población pediátrica. Entre las causas frecuentes se encuentran los aeroalérgenos del ambiente, y la identificación de estos es de gran ayuda tanto para el diagnóstico como para el tratamiento. Objetivos: Determinar la frecuencia de aeroalérgenos, por medio de la determinación de Inmunoglobulina E (IgE) específica a alérgenos comunes por la prueba de sensibilidad cutánea en pacientes pediátricos con síntomas de asma y rinitis alérgica. Materiales y Métodos: Diseño observacional, descriptivo, prospectivo, transversal, población de pacientes de 4 a 17 años con síntomas compatibles con asma y rinitis alérgica que acudieron a un centro asistencial pediátrico en el periodo de estudio. Se realizó por medio de las Pruebas de punción cutánea (PCP). Resultados: La edad media de los pacientes fue de 8 años, 57% pacientes de sexo masculino y 43% de sexo femenino. El 53% de los pacientes presenta rinitis y asma, 45% solo rinitis y el 2% solo asma. El 79% de los pacientes presentó reacción positiva de sensibilización alérgica por medio de la PCP. Teniendo en cuenta la sensibilización por tipo de aeroalérgenos se tuvo que el 64% de los pacientes tuvo reacción positiva a ácaros, 19% a animales 18% a cucarachas, 8% a pólenes y 6% a hongos. Conclusión: La gran mayoría de pacientes con asma padecía rinitis alérgica concomitante y los ácaros del polvo fueron los aeroalérgenos más frecuentemente determinados en las pruebas cutáneas de alergia en niños con asma y rinitis de nuestra población.

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“…Quantifying allergic sensitization instead, by using IgE titre or size of skin test response, can increase specificity both in terms of diagnostic accuracy [16,17] and capacity to predict the persistence of symptoms [18]; however, a significant number of false-positive test results remain [3,4]. Consequently, although asthma is closely associated with allergic sensitization, most current guidelines do not recommend assessing allergic sensitization for asthma diagnosis or monitoring [19 ▪ ]; nonetheless, most physicians caring for asthmatic children consider monitoring allergy and assessment of sensitization status to be of very high or high priority when monitoring childhood asthma [20 ▪▪ ].…”

Section: Introduction: How Is Sensitization Linked To Atopic Diseases?mentioning

confidence: 99%

Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma

Custovic,

Fontanella

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To review the current state of knowledge on the relationship between allergic sensitization and asthma; to lay out a roadmap for the development of IgE biomarkers that differentiate, in individual sensitized patients, whether their sensitization is important for current or future asthma symptoms, or has little or no relevance to the disease. Recent findings The evidence on the relationship between sensitization and asthma suggests that some subtypes of allergic sensitization are not associated with asthma symptoms, whilst others are pathologic. Interaction patterns between IgE antibodies to individual allergenic molecules on component-resolved diagnostics (CRD) multiplex arrays might be hallmarks by which different sensitization subtypes relevant to asthma can be distinguished. These different subtypes of sensitization are associated amongst sensitized individuals at all ages, with different clinical presentations (no disease, asthma as a single disease, and allergic multimorbidity); amongst sensitized preschool children with and without lower airway symptoms, with different risk of subsequent asthma development; and amongst sensitized patients with asthma, with differing levels of asthma severity. Summary The use of machine learning-based methodologies on complex CRD data can help us to design better diagnostic tools to help practising physicians differentiate between benign and clinically important sensitization.

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Environmental influences on childhood asthma: Allergens

Cited by 22 publications

References 142 publications

A multicenter analysis on the changes of sIgE in China during the early period of COVID‐19 pandemic

A multicenter analysis on the changes of sIgE in China during the early period of COVID‐19 pandemic

Sensibilización cutánea a aeroalérgenos en niños con rinitis y asma

Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma

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