“…Disruption in the prefrontal cortex has been implicated in problems of inhibitory control, attention, increased risk taking behaviors, and executive function (Thompson et al, 2009), all of which likely contribute to sexual risk behaviors (Goldenberg et al, 2013; Khurana et al, 2012). In addition, PCE may indirectly increase vulnerability to sexual risk behavior through biological and environmental confounders, including prenatal exposure to other substances such as alcohol (Larkby et al, 2011), tobacco (Maughan et al, 2004), and marijuana (Goldschmidt et al, 2000), ongoing parental substance abuse (Elkington et al, 2011) and psychological distress (Minnes et al, 2010), and elevated lead (≥ 10 μg/dL) levels (Lane et al, 2008; Min et al, 2009; Singer et al, 2008). Further, poor quality of the home environment (Singer et al, 2008) including poor attachment to caregiver (Warner et al, 2011) and inadequate parental monitoring (Min et al, 2014a, 2014b), sexual victimization (De Genna et al, 2014), violence exposure (Frank et al, 2011), and adoptive/foster care placement (Singer et al, 2004) may obscure the effects of PCE.…”