This theoretical examination explores the challenges and approaches to establishing ethical frameworks for the integration of artificial intelligence (AI) in healthcare entrepreneurship. As AI technologies continue to advance, their applications in healthcare hold immense potential for improving patient outcomes and driving innovation. However, ethical considerations are paramount to ensure the responsible and equitable deployment of AI-driven solutions. This paper delves into key ethical dimensions including privacy and data security, bias and fairness, accountability and transparency, and patient autonomy and consent. It identifies challenges such as technological limitations, regulatory complexities, and organizational barriers that impede the implementation of ethical frameworks. Additionally, it proposes approaches including collaborative governance models, ethical design practices, and continuous monitoring and evaluation to address these challenges. Through case studies and examples, the paper illustrates successful implementations of ethical frameworks in AI healthcare startups, highlighting lessons learned and their impact on patient outcomes and trust. Ultimately, this examination underscores the critical importance of ethical considerations in shaping the future of AI in healthcare entrepreneurship and provides insights for researchers, practitioners, and policymakers navigating this rapidly evolving landscape.